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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12152 scientific papers returned from the database with the search filters currently being used below.
There are 12152 scientific papers returned from the database with the search filters currently being used below.
Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy
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Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037 Epub:
Yes Abstract:
Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by the CTG repeat expansion in the 3′-untranslated... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: HL-1 Citation Extract: Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A. Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037. |
Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling
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Citation:
EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693 Epub:
Yes Abstract:
The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis.... Organism or Cell Type:
Xenopus Citation Extract: Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C. Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling. EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693. |
Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model
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Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa126 Epub:
Yes Abstract:
Spinal muscular atrophy (SMA) is a motor neuron disease. Nusinersen, a splice-switching antisense oligonucleotide (ASO), was... Delivery Method:
subcutaneous (s.c.) injection Organism or Cell Type:
mice Citation Extract: Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y. Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa126. |
pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms
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Citation:
Development. 2020;147:[Epub ahead of print] doi:10.1242/dev.182139 Epub:
Not Epub Abstract:
In several model animals, the earliest phases of embryogenesis are regulated by lineage-specific genes, such as Drosophila... Delivery Method:
microinjection Organism or Cell Type:
Patria pectinifera (sea star) Citation Extract: Yamazaki A, Morino Y, Urata M, Yamaguchi M, Minokawa T, Furukawa R, Kondo M, Wada H. pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms. Development. 2020;147:[Epub ahead of print] doi:10.1242/dev.182139. |
Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
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Citation:
Nat Commun. 2020;11:1073 doi:s41467-019-14063-8 Epub:
Not Epub Abstract:
Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased... Delivery Method:
lipofectamine 2000 Organism or Cell Type:
cell culture: myofibrils Citation Extract: Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo CP, Sáez JC. Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation. Nat Commun. 2020;11:1073 doi:s41467-019-14063-8. |
Histone variant dictates fate biasing of neural crest cells to melanocyte lineage
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Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.182576 Epub:
Yes Abstract:
In the neural crest lineage, progressive fate-restriction and stem cell assignment are critical for both development and... Organism or Cell Type:
zebrafish Citation Extract: Raja DA, Subramaniam Y, Aggarwal A, Gotherwal V, Babu A, Tanwar J, Motiani RK, Sivasubbu S, Gokhale RS, Natarajan VT. Histone variant dictates fate biasing of neural crest cells to melanocyte lineage. Development. 2020;[Epub ahead of print] doi:10.1242/dev.182576. |
New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration
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Citation:
FASEB J. 2017 Jan;31(1):238-255. doi: 10.1096/fj.201600675r Epub:
Not Epub Abstract:
Skeletal muscle fibrosis and impaired muscle regeneration are major contributors to muscle wasting in Duchenne muscular... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: C2C12 myoblasts, 4-wk-old male mdx or 3-mo-old male C57BL/6Jico WT mice Citation Extract: Pasteuning-Vuhman S, Boertje-van der Meulen JW, Putten MV, Overzier M, Ten Dijke P, Kielbasa SM, Arindrarto W, Wolterbeek R, Lezhnina KV, Ozerov IV, Aliper AM, Hoogaars WM, Aartsma-Rus A, Loomans CJM. New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration. FASEB J. 2017 Jan;31(1):238-255. doi: 10.1096/fj.201600675r. |
Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42
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Citation:
Open Biol. 2020 Feb;10(2):190273. doi: 10.1098/rsob.190273. Epub 2020 Feb 26 Epub:
Not Epub Abstract:
Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hung IC, Chen TM, Lin JP, Tai YL, Shen TL, Lee SJ. Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42. Open Biol. 2020 Feb;10(2):190273. doi: 10.1098/rsob.190273. Epub 2020 Feb 26. |
Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network
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Citation:
Elife. 2020 Sep 7;9:e58029. doi: 10.7554/eLife.58029. PMID: 32894225; PMCID: PMC7498262 Epub:
Not Epub Abstract:
Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis Citation Extract: Mukherjee S, Chaturvedi P, Rankin SA, Fish MB, Wlizla M, Paraiso KD, MacDonald M, Chen X, Weirauch MT, Blitz IL, Cho KW, Zorn AM. Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network. Elife. 2020 Sep 7;9:e58029. doi: 10.7554/eLife.58029. PMID: 32894225; PMCID: PMC7498262. |
Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development
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Citation:
Cell Death Differ. 2020;[Epub] doi:10.1038/s41418-020-0516-1 Epub:
Yes Abstract:
KIAA1429 (also known as vir-like m6A methyltransferase-associated protein (VIRMA)), a newly identified component of the RNA m6A... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Hu Y, Ouyang Z, Sui X, Qi M, Li M, He Y, Cao Y, Cao Q, Lu Q, Zhou S, Liu L, Liu L, Shen B, Shu W, Huo R. Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development. Cell Death Differ. 2020;[Epub] doi:10.1038/s41418-020-0516-1. |