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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12152 scientific papers returned from the database with the search filters currently being used below.

Cryptic exon activation causes dystrophinopathy in two Chinese families

Authors:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q
Citation:
Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z
Epub:
Yes
Abstract:
The X-linked recessive degenerative disease dystrophinopathy results from variants in the DMD gene. Given the large size and...
Link:
https://www.nature.com/articles/s41431-020-0578-z
Citation Extract:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q. Cryptic exon activation causes dystrophinopathy in two Chinese families. Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z.

Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy

Authors:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F
Citation:
J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):768-782. doi: 10.1002/jcsm.12542. Epub 2020 Feb 7. PMID: 32031328; PMCID: PMC7296258
Epub:
Yes
Abstract:
BACKGROUND: Spinal muscular atrophy (SMA) is caused by genetic defects in the survival motor neuron 1 (SMN1) gene that lead to...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7296258/
Delivery Method:
s.c. injection
Organism or Cell Type:
mice
Citation Extract:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F. Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy. J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):768-782. doi: 10.1002/jcsm.12542. Epub 2020 Feb 7. PMID: 32031328; PMCID: PMC7296258.

Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging

Authors:
Yew HM, Zimmer AM, Perry SF
Citation:
J Exper Biol. 2020;[Epub ahead of print] doi:10.1242/jeb.212928
Epub:
Yes
Abstract:
The H+-ATPase rich (HR) cells of zebrafish larvae are a sub-type of ion-transporting cell located on the yolk sac epithelium...
Link:
https://jeb.biologists.org/content/early/2020/02/04/jeb.212928
Organism or Cell Type:
zebrafish
Citation Extract:
Yew HM, Zimmer AM, Perry SF. Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging. J Exper Biol. 2020;[Epub ahead of print] doi:10.1242/jeb.212928.

Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation

Authors:
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ
Citation:
Cell Mol Life Sci. 2020 Feb 1. doi: 10.1007/s00018-020-03465-3. [Epub ahead of print]
Epub:
Yes
Abstract:
Background: Small bowel vascular malformation disease (SBVM) is the most common cause of obscure gastrointestinal bleeding (...
Link:
https://link.springer.com/article/10.1007%2Fs00018-020-03465-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ. Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation. Cell Mol Life Sci. 2020 Feb 1. doi: 10.1007/s00018-020-03465-3. [Epub ahead of print].

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

Authors:
Sitaraman S, Yadav G, Agarwal V, Jabeen S, Verma S, Jadhav M, Thirumalai V
Citation:
Elife. 2021 Aug 4;10:e68124. doi: 10.7554/eLife.68124. PMID: 34346310; PMCID: PMC8382294
Epub:
Not Epub
Abstract:
Gap junctions between neurons serve as electrical synapses, in addition to conducting metabolites and signaling molecules....
Link:
https://elifesciences.org/articles/68124
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sitaraman S, Yadav G, Agarwal V, Jabeen S, Verma S, Jadhav M, Thirumalai V. Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. Elife. 2021 Aug 4;10:e68124. doi: 10.7554/eLife.68124. PMID: 34346310; PMCID: PMC8382294.

Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development

Authors:
Rojas-Benítez D, Allende ML
Citation:
Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925
Epub:
Not Epub
Abstract:
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the...
Link:
https://www.mdpi.com/1422-0067/21/3/925
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rojas-Benítez D, Allende ML. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925.

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

Authors:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y
Citation:
J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004
Epub:
Yes
Abstract:
The CRISPR/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1673852720300102
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y. Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs. J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004.

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish

Authors:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Saran NK, Ramachandran R
Citation:
iScience. 2020 Jan 7;23(2):100817. doi: 10.1016/j.isci.2019.100817. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Tgf-β signaling is a major antiproliferative pathway governing different biological functions, including cellular reprogramming...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004219305632
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Saran NK, Ramachandran R. Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 2020 Jan 7;23(2):100817. doi: 10.1016/j.isci.2019.100817. [Epub ahead of print].

The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development

Authors:
Loreti M, Shi DL, Carron C
Citation:
J Biol Chem. 2020;295, 2724-2735. doi: 10.1074/jbc.RA119.010719.
Epub:
Not Epub
Abstract:
Embryonic cell fate specification and axis patterning requires integration of several signaling pathways that orchestrate...
Link:
https://www.jbc.org/content/early/2020/01/29/jbc.RA119.010719.abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Loreti M, Shi DL, Carron C. The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development. J Biol Chem. 2020;295, 2724-2735. doi: 10.1074/jbc.RA119.010719. .

Greb1 is required for axial elongation and segmentation in vertebrate embryos

Authors:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D
Citation:
Biol Open. 2020 Jan 27. pii: bio.047290. doi: 10.1242/bio.047290. [Epub ahead of print]
Epub:
Yes
Abstract:
During vertebrate embryonic development, the formation of axial structures is driven by a population of stem-like cells that...
Link:
https://bio.biologists.org/content/early/2020/01/17/bio.047290.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D. Greb1 is required for axial elongation and segmentation in vertebrate embryos. Biol Open. 2020 Jan 27. pii: bio.047290. doi: 10.1242/bio.047290. [Epub ahead of print].

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