You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Kctd15 regulates nephron segment development by repressing Tfap2a activity

Authors:
Chambers BE, Clark EG, Gatz AE, Wingert RA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.17.910760
Epub:
Not Epub
Abstract:
A functional vertebrate kidney relies on structural units called nephrons, which are epithelial tubules that contain a sequence...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.17.910760v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers BE, Clark EG, Gatz AE, Wingert RA. Kctd15 regulates nephron segment development by repressing Tfap2a activity. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.17.910760 .

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Authors:
Kainov YA, Makeyev EV
Citation:
Nat Commun. 2020 Jan 17;11(1):361. doi: 10.1038/s41467-019-14204-z
Epub:
Not Epub
Abstract:
Eukaryotic gene expression relies on extensive crosstalk between transcription and RNA processing. Changes in this composite...
Link:
https://www.nature.com/articles/s41467-019-14204-z
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: A2lox mouse ESCs (embryonic stem cells)
Citation Extract:
Kainov YA, Makeyev EV. A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells. Nat Commun. 2020 Jan 17;11(1):361. doi: 10.1038/s41467-019-14204-z.

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin

Authors:
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M
Citation:
Nucleic Acids Res. 2020 Jan 16. pii: gkz1213. doi: 10.1093/nar/gkz1213. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Besides analyses of specific alternative splicing (AS) variants, little is known about AS regulatory pathways and programs...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz1213/5707190
Delivery Method:
Endo-Porter PEG; Vivo-Morpholino
Organism or Cell Type:
cell culture: MCF7-DoxoR; female Swiss Nu/nu mice intratumoral
Citation Extract:
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M. ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin. Nucleic Acids Res. 2020 Jan 16. pii: gkz1213. doi: 10.1093/nar/gkz1213. [Epub ahead of print].

Microglial activation increases cocaine self-administration following adolescent nicotine exposure

Authors:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM
Citation:
Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3
Epub:
Not Epub
Abstract:
With the rise of e-cigarette use, teen nicotine exposure is becoming more widespread. Findings from clinical and preclinical...
Link:
https://www.nature.com/articles/s41467-019-14173-3
Delivery Method:
intracranial Vivo-Morpholino
Organism or Cell Type:
Sprague-Dawley rat
Citation Extract:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM. Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3.

The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation

Authors:
Wang Y, Liu X, Xie B, Yuan H, Zhang Y, Zhu J
Citation:
Redox Biol. 2020 Jan;28:101313. doi: 10.1016/j.redox.2019.101313. Epub 2019 Sep 2
Epub:
Not Epub
Abstract:
Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery...
Link:
https://www.sciencedirect.com/science/article/pii/S2213231719305476
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang Y, Liu X, Xie B, Yuan H, Zhang Y, Zhu J. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biol. 2020 Jan;28:101313. doi: 10.1016/j.redox.2019.101313. Epub 2019 Sep 2.

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

Authors:
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C
Citation:
Elife. 2020 Jan 14;9. pii: e51248. doi: 10.7554/eLife.51248. [Epub ahead of print]
Epub:
Not Epub
Abstract:
A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we...
Link:
https://elifesciences.org/articles/51248
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. Elife. 2020 Jan 14;9. pii: e51248. doi: 10.7554/eLife.51248. [Epub ahead of print].

Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

Authors:
Parra M, Zhang W, Vu J, DeWitt M, Conboy JG
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.13.902544
Epub:
Not Epub
Abstract:
Galanin (Gal) is a peptide with a role in neuroendocrine regulation of the liver. In this study we assessed the role of Gal and...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.13.902544v1
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human erythroblasts
Citation Extract:
Parra M, Zhang W, Vu J, DeWitt M, Conboy JG. Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.13.902544.

Co-ordinated targeting of galanin receptors on cholangiocytes and hepatic stellate cells ameliorates liver fibrosis in Mdr2-knockout mice

Authors:
Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S
Citation:
Am J Pathol. 2020 Jan 14. pii: S0002-9440(20)30003-1. doi: 10.1016/j.ajpath.2019.10.023. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Galanin (Gal) is a peptide with a role in neuroendocrine regulation of the liver. In this study we assessed the role of Gal and...
Link:
https://ajp.amjpathol.org/article/S0002-9440(20)30003-1/fulltext
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S. Co-ordinated targeting of galanin receptors on cholangiocytes and hepatic stellate cells ameliorates liver fibrosis in Mdr2-knockout mice. Am J Pathol. 2020 Jan 14. pii: S0002-9440(20)30003-1. doi: 10.1016/j.ajpath.2019.10.023. [Epub ahead of print].

Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model

Authors:
Da'as SI, Yalcin HC, Nasrallah GK, Mohamed IA, Nomikos M, Yacoub MH, Fakhro KA
Citation:
J Cell Physiol. 2020 Jan 13. doi: 10.1002/jcp.29441. [Epub ahead of print]
Epub:
Yes
Abstract:
Myosin‐binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29441
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Da'as SI, Yalcin HC, Nasrallah GK, Mohamed IA, Nomikos M, Yacoub MH, Fakhro KA. Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model. J Cell Physiol. 2020 Jan 13. doi: 10.1002/jcp.29441. [Epub ahead of print].

Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos

Authors:
Tseng YT, Ko CL, Chang CT, Lee YH, Huang Fu WC, Liu IH
Citation:
Biol Open. 2020 Jan 15. pii: bio.048264. doi: 10.1242/bio.048264. [Epub ahead of print]
Epub:
Yes
Abstract:
The sodium osmotic gradient is necessary for the initiation of brain ventricle inflation, but a previous study predicted that...
Link:
https://bio.biologists.org/content/early/2020/01/08/bio.048264
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tseng YT, Ko CL, Chang CT, Lee YH, Huang Fu WC, Liu IH. Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos. Biol Open. 2020 Jan 15. pii: bio.048264. doi: 10.1242/bio.048264. [Epub ahead of print].

Pages