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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo
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Citation:
Nat Biotechnol. 2019;[Epub ahead print] doi:10.1038/s41587-019-0357-y Epub:
Not Epub Abstract:
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell cultures, mice Citation Extract: Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M. A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo. Nat Biotechnol. 2019;[Epub ahead print] doi:10.1038/s41587-019-0357-y. |
Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome
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Citation:
Matrix Biol. 2019 Dec 17. pii: S0945-053X(19)30400-7. doi: 10.1016/j.matbio.2019.12.002. [Epub ahead of print] Epub:
Yes Abstract:
β4GalT7 is a transmembrane Golgi enzyme, encoded by B4GALT7, that plays a pivotal role in the proteoglycan linker region... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Delbaere S, Van Damme T, Syx D, Symoens S, Coucke P, Willaert A, Malfait F. Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome. Matrix Biol. 2019 Dec 17. pii: S0945-053X(19)30400-7. doi: 10.1016/j.matbio.2019.12.002. [Epub ahead of print]. |
Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/2019.12.19.880815 Epub:
Not Epub Abstract:
Background: Congenital hypothyroidism (CH) due to thyroid dysgenesis is a frequent congenital endocrine disorder for which the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vandernoot I, Haerlingen B, Trubiroha A, Gillotay P, Janssens V, Opitz R, Costagliola S. Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects. bioRxiv. 2019;[preprint] doi:10.1101/2019.12.19.880815. |
Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease
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Citation:
Dis Model Mech. 2019;[Epub ahead of print] doi:10.1242/dmm.041426 Epub:
Yes Abstract:
Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Clark EM, Nonarath HJT, Bostrom JR, Link BA. Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease. Dis Model Mech. 2019;[Epub ahead of print] doi:10.1242/dmm.041426. |
Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology
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Citation:
J Cachexia Sarcopenia Musc. 2019;[Epub] doi:10.1002/jcsm.12506 Epub:
Yes Abstract:
Background: Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein.... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: van Westering TLE, Lomonosova Y, Coenen‐Stass AML, Betts CA, Bhomra A, Hulsker M, Clark LE, McClorey G, Aartsma‐Rus A, van Putten M, Wood MJA, Roberts TC. Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology. J Cachexia Sarcopenia Musc. 2019;[Epub] doi:10.1002/jcsm.12506. |
The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis
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Citation:
J Biol Chem. 2019;[Epub ahead of print] doi:10.1074/jbc.RA119.011751 Epub:
Yes Abstract:
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best characterized inflammasomes in humans and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li J-Y, Wang Y-Y, Shao T, Fan D-D, Lin A-F, Xiang L-X, Shao J-Z. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis. J Biol Chem. 2019;[Epub ahead of print] doi:10.1074/jbc.RA119.011751. |
Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing
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Citation:
J Exp Biol. 2019;[Epub ahead of print] doi: 10.1242/jeb.215111 Epub:
Yes Abstract:
Freshwater fishes absorb Na+ from their dilute environment using ion-transporting cells. In larval zebrafish (Danio rerio), Na... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zimmer AM, Shir-Mohammadi K, Kwong RWM, Perry SF. Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing. J Exp Biol. 2019;[Epub ahead of print] doi: 10.1242/jeb.215111. |
Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch-hoxb5b Signaling and Underlying DNA Methylation
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Citation:
bioRxiv. 2019:[preprint] doi:10.1101/2019.12.16.877860 Epub:
Not Epub Abstract:
Unbalanced copper (Cu2+) homeostasis is associated with neurological development defects and diseases. However, the molecular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang T, Guan PP, Zhao G, Fang YP, Fu H, Gui J-F, Li GL, Liu J-X. Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch-hoxb5b Signaling and Underlying DNA Methylation. bioRxiv. 2019:[preprint] doi:10.1101/2019.12.16.877860. |
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
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Citation:
Cell Rep. 2019;29(12):3885-3901. doi:10.1016/j.celrep.2019.11.058 Epub:
Not Epub Abstract:
Reduced expression of the survival motor neuron (SMN) protein causes the neurodegenerative disease spinal muscular atrophy (SMA... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: NIH 3T3 Citation Extract: Simon CM, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson DM, Mentis GZ, Pellizzoni L. Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy. Cell Rep. 2019;29(12):3885-3901. doi:10.1016/j.celrep.2019.11.058. |
Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy
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Citation:
Genes Dev. 2018 Aug 1;32(15-16):1045-1059. doi: 10.1101/gad.316059.118. Epub 2018 Jul 16 Epub:
Not Epub Abstract:
Ubiquitous deficiency in the survival motor neuron (SMN) protein causes death of motor neurons-a hallmark of the... Delivery Method:
intracerebroventricular (i.c.v.) injection Organism or Cell Type:
mice Citation Extract: Van Alstyne M, Simon CM, Sardi SP, Shihabuddin LS, Mentis GZ, Pellizzoni L. Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy. Genes Dev. 2018 Aug 1;32(15-16):1045-1059. doi: 10.1101/gad.316059.118. Epub 2018 Jul 16. |