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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

The role of nitric oxide during embryonic wound healing

Authors:
Abaffy P, Tomankova S, Naraine R, Kubista M, Sindelka R
Citation:
BMC Genomics. 2019 Nov 6;20(1):815. doi: 10.1186/s12864-019-6147-6
Epub:
Not Epub
Abstract:
BACKGROUND: The study of the mechanisms controlling wound healing is an attractive area within the field of biology, with it...
Link:
https://link.springer.com/article/10.1186/s12864-019-6147-6
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Abaffy P, Tomankova S, Naraine R, Kubista M, Sindelka R. The role of nitric oxide during embryonic wound healing. BMC Genomics. 2019 Nov 6;20(1):815. doi: 10.1186/s12864-019-6147-6.

miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish

Authors:
Guzzolino E, Pellegrino M, Ahuja N, Garrity D, D'Aurizio R, Groth M, Baumgart M, Hatcher CJ, Mercatanti A, Evangelista M, Ippolito C, Tognoni E, Fukuda R, Lionetti V, Pellegrini M, Cremisi F, Pitto L
Citation:
Cell Mol Life Sci. 2019 Nov 4. doi: 10.1007/s00018-019-03343-7. [Epub ahead of print]
Epub:
Not Epub
Abstract:
To dissect the TBX5 regulatory circuit, we focused on microRNAs (miRNAs) that collectively contribute to make TBX5 a pivotal...
Link:
https://link.springer.com/article/10.1007%2Fs00018-019-03343-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guzzolino E, Pellegrino M, Ahuja N, Garrity D, D'Aurizio R, Groth M, Baumgart M, Hatcher CJ, Mercatanti A, Evangelista M, Ippolito C, Tognoni E, Fukuda R, Lionetti V, Pellegrini M, Cremisi F, Pitto L. miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish. Cell Mol Life Sci. 2019 Nov 4. doi: 10.1007/s00018-019-03343-7. [Epub ahead of print].

The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response

Authors:
Seifert LL, Si C, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez AM, Mohamed A, Schaefer U, Moulton HM, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M
Citation:
PLoS Pathog. 2019 Nov 4;15(11):e1007634. doi: 10.1371/journal.ppat.1007634. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Induction of vast transcriptional programs is a central event of innate host responses to viral infections. Here we report a...
Link:
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007634
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Seifert LL, Si C, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez AM, Mohamed A, Schaefer U, Moulton HM, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M. The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response. PLoS Pathog. 2019 Nov 4;15(11):e1007634. doi: 10.1371/journal.ppat.1007634. [Epub ahead of print].

A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping

Authors:
Demonbreun AR, Wyatt EJ, Fallon KS, Oosterbaan CC, Page PG, Hadhazy M, Quattrocelli M, Barefield DY, McNally EM
Citation:
Dis Model Mech. 2019 Nov 4;13(2). pii: dmm040832. doi: 10.1242/dmm.040832
Epub:
Not Epub
Abstract:
Limb-girdle muscular dystrophy type 2C is caused by autosomal recessive mutations in the γ-sarcoglycan (SGCG) gene. The most...
Link:
https://dmm.biologists.org/content/13/2/dmm040832
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice 521ΔT
Citation Extract:
Demonbreun AR, Wyatt EJ, Fallon KS, Oosterbaan CC, Page PG, Hadhazy M, Quattrocelli M, Barefield DY, McNally EM. A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping. Dis Model Mech. 2019 Nov 4;13(2). pii: dmm040832. doi: 10.1242/dmm.040832.

Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH

Authors:
Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, Zhou Y, Xue L, Zhang Y, Liu D, Meng W, Zhang W, Zhang X, Shen X, Sun Q, Li L, Ma C, Wei Y, Billadeau DD, Mo X, Jia D
Citation:
Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22598-22608. doi: 10.1073/pnas.1909316116. Epub 2019 Oct 17
Epub:
Not Epub
Abstract:
Pontocerebellar hypoplasia (PCH) is a group of neurological disorders that affect the development of the brain, in particular,...
Link:
https://www.pnas.org/content/116/45/22598
Organism or Cell Type:
zebrafish
Citation Extract:
Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, Zhou Y, Xue L, Zhang Y, Liu D, Meng W, Zhang W, Zhang X, Shen X, Sun Q, Li L, Ma C, Wei Y, Billadeau DD, Mo X, Jia D. Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22598-22608. doi: 10.1073/pnas.1909316116. Epub 2019 Oct 17.

Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians

Authors:
Néant I, Leung HC, Webb SE, Miller AL, Moreau M, Leclerc C
Citation:
Sci Rep. 2019 Nov 5;9(1):16049. doi: 10.1038/s41598-019-52556-0
Epub:
Not Epub
Abstract:
In amphibians, the inhibition of bone morphogenetic protein (BMP) in the dorsal ectoderm has been proposed to be responsible...
Link:
https://www.nature.com/articles/s41598-019-52556-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Néant I, Leung HC, Webb SE, Miller AL, Moreau M, Leclerc C. Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians. Sci Rep. 2019 Nov 5;9(1):16049. doi: 10.1038/s41598-019-52556-0.

Targeted resequencing identifies genes with recurrent variation in cerebral palsy

Authors:
van Eyk CL, Corbett MA, Frank MSB, Webber DL, Newman M, Berry JG, Harper K, Haines BP, McMichael G, Woenig JA, MacLennan AH, Gecz J
Citation:
NPJ Genom Med. 2019 Nov 4;4:27. doi: 10.1038/s41525-019-0101-z. eCollection 2019
Epub:
Not Epub
Abstract:
A growing body of evidence points to a considerable and heterogeneous genetic aetiology of cerebral palsy (CP). To identify...
Link:
https://www.nature.com/articles/s41525-019-0101-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van Eyk CL, Corbett MA, Frank MSB, Webber DL, Newman M, Berry JG, Harper K, Haines BP, McMichael G, Woenig JA, MacLennan AH, Gecz J. Targeted resequencing identifies genes with recurrent variation in cerebral palsy. NPJ Genom Med. 2019 Nov 4;4:27. doi: 10.1038/s41525-019-0101-z. eCollection 2019.

CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch

Authors:
Nagarajan B, Harder A, Japp A, Häberlein F, Mingardo E, Kleinert H, Yilmaz Ö, Zoons A, Rau B, Christ A, Kubitscheck U, Eiberger B, Sandhoff R, Eckhardt M, Hartmann D, Odermatt B
Citation:
Glia. 2019 Nov 8. doi: 10.1002/glia.23732. [Epub ahead of print]
Epub:
Yes
Abstract:
In contrast to humans and other mammals, zebrafish can successfully regenerate and remyelinate central nervous system (CNS)...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.23732
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nagarajan B, Harder A, Japp A, Häberlein F, Mingardo E, Kleinert H, Yilmaz Ö, Zoons A, Rau B, Christ A, Kubitscheck U, Eiberger B, Sandhoff R, Eckhardt M, Hartmann D, Odermatt B. CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 2019 Nov 8. doi: 10.1002/glia.23732. [Epub ahead of print].

AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos

Authors:
Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y, Chen T
Citation:
J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print]
Epub:
Yes
Abstract:
Trichloroethylene (TCE), a widely used chlorinated solvent, is a common environmental pollutant. Current evidence shows that...
Link:
https://www.sciencedirect.com/science/article/pii/S030438941931475X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y, Chen T. AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print].

Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model

Authors:
Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA
Citation:
J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Lowe syndrome (LS) is an X-linked recessive disorder caused by mutations in OCRL, which encodes the enzyme OCRL....
Link:
https://jasn.asnjournals.org/content/early/2019/10/30/ASN.2019020125.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA. Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model. J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print].

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