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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells
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Citation:
J Cell Biol. 2020;219(4):e201911129. doi:10.1083/jcb.201911129 Epub:
Yes Abstract:
Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Smith JA, Curry EG, Blue RE, Roden C, Dundon SER, Rodríguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb ME, Gladfelter AS , Giudice J. FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. J Cell Biol. 2020;219(4):e201911129. doi:10.1083/jcb.201911129. |
Genetic Compensation of γ CaMKII, an Evolutionarily Conserved Gene
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Citation:
Gene. 2020 Mar 9:144567. doi: 10.1016/j.gene.2020.144567. [Epub ahead of print] Epub:
Yes Abstract:
CaMKII is a Ca2+/CaM-dependent protein kinase encoded by a family of conserved genes found throughout all metazoan species and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rothschild SC, Ingram SR, Lu FI, Thisse B, Thisse C, Parkerson JA, Tombes RM. Genetic Compensation of γ CaMKII, an Evolutionarily Conserved Gene. Gene. 2020 Mar 9:144567. doi: 10.1016/j.gene.2020.144567. [Epub ahead of print]. |
The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development
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Citation:
J Trace Elem Med Bio. 2020 Mar 12;60:126496. doi: 10.1016/j.jtemb.2020.126496. [Epub ahead of print] Epub:
Not Epub Abstract:
Background: Zinc is one of the vital micronutrients required through various developmental stages in animals. Zinc transporter-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C. The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. J Trace Elem Med Bio. 2020 Mar 12;60:126496. doi: 10.1016/j.jtemb.2020.126496. [Epub ahead of print]. |
miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
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Citation:
Cells. 2020;9(3):2073-4409 doi:10.3390/cells9030711 Epub:
Not Epub Abstract:
During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Adusumilli L, Facchinello N, Teh C, Busolin G, Le TM, Yang H, Beffagna G, Campanaro S, Tam LW, Argenton F, Lim B, Korzh V, Tiso N. miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 2020;9(3):2073-4409 doi:10.3390/cells9030711. |
Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy
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Citation:
Neurology. 2020 Mar 5. pii: 10.1212/WNL.0000000000009233. doi: 10.1212/WNL.0000000000009233. [Epub ahead of print] Epub:
Yes Abstract:
Objective: To report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated patients with... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Frank DE, Schnell FJ, Akana C, El-Husayni SH, Desjardins CA, Morgan J, Charleston JS, Sardone V, Domingos J, Dickson G, Straub V, Guglieri M, Mercuri E, Servais L, Muntoni F; SKIP-NMD Study Group. Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy. Neurology. 2020 Mar 5. pii: 10.1212/WNL.0000000000009233. doi: 10.1212/WNL.0000000000009233. [Epub ahead of print]. |
The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation
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Citation:
Nat Comm. 2020;11:1399. doi:10.1038/s41467-020-15209-9 Epub:
Not Epub Abstract:
Deleted in azoospermia-like (DAZL) is an RNA-binding protein critical for gamete development. In full-grown oocytes, the DAZL... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Yang C-R, Rajkovic G, Daldello EM, Luong XG, Chen J, Conti M. The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Nat Comm. 2020;11:1399. doi:10.1038/s41467-020-15209-9. |
Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease
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Citation:
FASEB J. 2020 Mar 11. doi: 10.1096/fj.201902901R. [Epub ahead of print] Epub:
Not Epub Abstract:
Tubular ATP release is regulated by mechanosensation of fluid shear stress (FSS). Polycystin-1/polycystin-2 (PC1/PC2) functions... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ. Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. FASEB J. 2020 Mar 11. doi: 10.1096/fj.201902901R. [Epub ahead of print]. |
U1 snRNP regulates chromatin retention of noncoding RNAs
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Citation:
Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2105-3 Epub:
Yes Abstract:
Long noncoding RNAs (lncRNAs) and promoter- or enhancer-associated unstable transcripts locate preferentially to chromatin,... Citation Extract: Yin Y, Lu JY, Zhang X, Shao W, Xu Y, Li P, Hong Y, Cui L, Shan G, Tian B, Zhang QC, Shen X. U1 snRNP regulates chromatin retention of noncoding RNAs. Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2105-3. |
Glycine enhances satellite cell proliferation, cell transplantation and oligonucleotide efficacy in dystrophic muscle
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Citation:
Molec Ther. 2020;28(5):1339-58. doi: 10.1016/j.ymthe.2020.03.003. [Epub ahead of print] Epub:
Not Epub Abstract:
The need to distribute therapy evenly systemically throughout the large muscle volume within the body makes Duchenne muscular... Organism or Cell Type:
mice Citation Extract: Lin C, Han G, Ning H, Song J, Ran N, Yi X, Seow Y, Yin HF. Glycine enhances satellite cell proliferation, cell transplantation and oligonucleotide efficacy in dystrophic muscle. Molec Ther. 2020;28(5):1339-58. doi: 10.1016/j.ymthe.2020.03.003. [Epub ahead of print]. |
Structural and mechanistic insights into secretagogin-mediated exocytosis
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Citation:
Proc Nat Acad Sci USA. 2020;201919698;[Epub ahead of print] doi:10.1073/pnas.1919698117 Epub:
Yes Abstract:
Secretagogin (SCGN) is a hexa–EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Qin J, Liu Q, Liu Z, Pan Y-Z, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D. Structural and mechanistic insights into secretagogin-mediated exocytosis. Proc Nat Acad Sci USA. 2020;201919698;[Epub ahead of print] doi:10.1073/pnas.1919698117. |