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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Dlc1 controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryo
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.11.430763 Epub:
Not Epub Abstract:
The family of deleted-in-liver-cancer (dlc) genes encodes RhoGTPases and plays pivotal roles in cardiovascular development, but... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Linnerz T, Bertrand JY. Dlc1 controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryo. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.11.430763. |
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production
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Citation:
Dev Cell. 2021 Mar 8;56(5):627-640.e5. doi: 10.1016/j.devcel.2021.02.006. Epub 2021 Mar 1 Epub:
Yes Abstract:
Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and are essential for sustaining the blood... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Weinreb JT, Ghazale N, Pradhan K, Gupta V, Potts KS, Tricomi B, Daniels NJ, Padgett RA, De Oliveira S, Verma A, Bowman TV. Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Dev Cell. 2021 Mar 8;56(5):627-640.e5. doi: 10.1016/j.devcel.2021.02.006. Epub 2021 Mar 1. |
Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
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Citation:
Nucl Acids Res. 2021;gkab118. doi:10.1093/nar/gkab118 Epub:
Not Epub Abstract:
Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by the major and minor spliceosomes... Delivery Method:
electroporation Organism or Cell Type:
cell culture: HEK293T Citation Extract: Olthof AM, White AK, Mieruszynski S, Doggett K, Lee MF, Chakroun A, Abdel Aleem AK, Rousseau J, Magnani C, Roifman CM, Campeau PM, Heath JK, Kanadia RN. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Nucl Acids Res. 2021;gkab118. doi:10.1093/nar/gkab118. |
Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides
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Citation:
Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print Epub:
Yes Abstract:
Antisense oligonucleotides (ASOs) are an emerging class of gene-specific therapeutics for diseases associated with the central... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Dastpeyman M, Sharifi R, Amin A, Karas JA, Cuic B, Pan Y, Nicolazzo JA, Turner BJ, Shabanpoor F. Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides. Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print. |
Expression and Functional Analyses of Ectodermal Transcription Factors FoxJ-r, SoxF, and SP8/9 in Early Embryos of the Ascidian Halocynthia roretzi
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Citation:
Zoolog Sci. 2021 Feb;38(1):26-35. doi: 10.2108/zs200128 Epub:
Not Epub Abstract:
The spatiotemporal expression of zygotic genes is regulated by transcription factors, which mediate cell fate decision and... Delivery Method:
microinjection Organism or Cell Type:
Halocynthia roretzi (ascidian) Citation Extract: Shih Y, Wang K, Kumano G, Nishida H. Expression and Functional Analyses of Ectodermal Transcription Factors FoxJ-r, SoxF, and SP8/9 in Early Embryos of the Ascidian Halocynthia roretzi. Zoolog Sci. 2021 Feb;38(1):26-35. doi: 10.2108/zs200128. |
Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways
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Citation:
Biology Open. 2021;10:bio050096 doi:10.1242/bio.050096 Epub:
Not Epub Abstract:
The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li GX, Zhang S, Liu R, Singh B, Singh S, Quinn DI, Crump G, Gill PS. Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 2021;10:bio050096 doi:10.1242/bio.050096. |
ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection
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Citation:
Commun Biol. 2021;4:251. doi:10.1038/s42003-021-01777-z Epub:
Not Epub Abstract:
Previous studies have shown that ELAVL1 plays multiple roles, but its overall biological function remains ill-defined. Here we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ni S, Zhou Y, Song L, Chen Y, Wang X, Du X, Zhang S. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection. Commun Biol. 2021;4:251. doi:10.1038/s42003-021-01777-z. |
The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing
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Citation:
Viruses. 2021;13(3):367. doi:10.3390/v13030367 Epub:
Not Epub Abstract:
In recent years, transcriptome profiling studies have identified changes in host splicing patterns caused by viral invasion,... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: HEK293 Citation Extract: Havranek KE, White LA, Bisom TC, Lanchy J-M, Lodmell JS. The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing. Viruses. 2021;13(3):367. doi:10.3390/v13030367. |
son is necessary for proper vertebrate blood development
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Citation:
PLoS One. 2021 Feb 25;16(2):e0247489. doi: 10.1371/journal.pone.0247489 Epub:
Not Epub Abstract:
The gene SON is on human chromosome 21 (21q22.11) and is thought to be associated with hematopoietic disorders that accompany... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Belmonte RL, Engbretson IL, Kim JH, Cajias I, Ahn EE, Stachura DL. son is necessary for proper vertebrate blood development. PLoS One. 2021 Feb 25;16(2):e0247489. doi: 10.1371/journal.pone.0247489. |
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease
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Citation:
Sci Rep. 2021;11(1):4722. doi:10.1038/s41598-021-84194-w Epub:
Not Epub Abstract:
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a... Delivery Method:
cell bathing Organism or Cell Type:
cell culture: HEK293, CV-1, primary human PTEC Citation Extract: Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Sci Rep. 2021;11(1):4722. doi:10.1038/s41598-021-84194-w. |