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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Leucyl-tRNA Synthetase Deficiency Systemically Induces Excessive Autophagy in Zebrafish

Authors:
Shiraishi H, Shimizu N, Tsumori M, Kiyota K, Maeda M, Ishitani T, Hanada R, Ihara K, Hanada T, Inoue M, Miyahara H
Citation:
Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-132893/v1
Epub:
Not Epub
Abstract:
Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to...
Link:
https://www.researchsquare.com/article/rs-132893/v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shiraishi H, Shimizu N, Tsumori M, Kiyota K, Maeda M, Ishitani T, Hanada R, Ihara K, Hanada T, Inoue M, Miyahara H. Leucyl-tRNA Synthetase Deficiency Systemically Induces Excessive Autophagy in Zebrafish. Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-132893/v1.

Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity

Authors:
Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L
Citation:
Cell Rep. 2021;34(1):108600. doi:10.1016/j.celrep.2020.108600
Epub:
Not Epub
Abstract:
Microgravity is a major environmental factor of space flight that triggers dysregulation of the immune system and increases...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31589-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L. Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity. Cell Rep. 2021;34(1):108600. doi:10.1016/j.celrep.2020.108600.

Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor

Authors:
Williams III CH, Neitzel LR, Karki P, Thayer TE, Keyesr BD, Wells QS, Perry JA, Birukov K, Birukova A, Hong CC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/612549
Epub:
Not Epub
Abstract:
An acidic milieu is a hallmark of the glycolytic metabolism that occurs in cancerous cells. The acidic environment is known to...
Link:
https://www.biorxiv.org/content/10.1101/612549v3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Williams III CH, Neitzel LR, Karki P, Thayer TE, Keyesr BD, Wells QS, Perry JA, Birukov K, Birukova A, Hong CC. Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor. bioRxiv. 2020;[preprint] doi:10.1101/612549.

12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

Authors:
Kulkarni A, Pineros AR, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Walsh M, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.01.02.424855
Epub:
Not Epub
Abstract:
Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1...
Link:
https://www.biorxiv.org/content/10.1101/2021.01.02.424855v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kulkarni A, Pineros AR, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Walsh M, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM. 12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes. bioRxiv. 2021;[preprint] doi:10.1101/2021.01.02.424855 .

Time-dependent pleiotropic phenotypes are caused by progressive DNA polymerase α deficiency in zebrafish

Authors:
Lin AY-S, Thomas GK, Ang K, van Rossum DB, Canfield VA, Cheng IKC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.31.425001
Epub:
Not Epub
Abstract:
The mechanisms underlying variation in cell- and tissue-specific phenotypes caused by mutations are poorly understood. For...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.31.425001v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin AY-S, Thomas GK, Ang K, van Rossum DB, Canfield VA, Cheng IKC. Time-dependent pleiotropic phenotypes are caused by progressive DNA polymerase α deficiency in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.31.425001.

Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis

Authors:
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L
Citation:
Hum Genet. 2021 Jan 4. doi: 10.1007/s00439-020-02243-2. Online ahead of print
Epub:
Yes
Abstract:
PIGK gene, encoding a key component of glycosylphosphatidylinositol (GPI) transamidase, was recently reported to be associated...
Link:
https://link.springer.com/article/10.1007%2Fs00439-020-02243-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L. Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis. Hum Genet. 2021 Jan 4. doi: 10.1007/s00439-020-02243-2. Online ahead of print.

HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function

Authors:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M
Citation:
Oxid Med Cell Longev. 2020;[Epub] doi:10.1155/2020/8706898
Epub:
Yes
Abstract:
Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals. HSP60 is a highly conserved stress protein...
Link:
https://www.hindawi.com/journals/omcl/2020/8706898/
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M. HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function. Oxid Med Cell Longev. 2020;[Epub] doi:10.1155/2020/8706898.

A globin-family protein, cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish

Authors:
Takahashi K, Ito Y, Yoshimura M, Nikaido M, Yuikawa T, Kawamura A, Tsuda S, Kage D, Yamasu K
Citation:
Dev Biol. 2020 Dec 22:S0012-1606(20)30325-0. doi: 10.1016/j.ydbio.2020.12.016. Online ahead of print
Epub:
Yes
Abstract:
The zebrafish is an excellent model animal that is amenable to forward genetics approaches. To uncover unknown developmental...
Link:
https://pubmed.ncbi.nlm.nih.gov/33358912/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Takahashi K, Ito Y, Yoshimura M, Nikaido M, Yuikawa T, Kawamura A, Tsuda S, Kage D, Yamasu K. A globin-family protein, cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish. Dev Biol. 2020 Dec 22:S0012-1606(20)30325-0. doi: 10.1016/j.ydbio.2020.12.016. Online ahead of print.

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Authors:
Xu J, Ji L, Liang Y, Wan Z, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, Chen J, Jin RA, Liang X, Cai X
Citation:
Signal Transduct Target Ther. 2020 Dec 26;5(1):298. doi: 10.1038/s41392-020-00375-5
Epub:
Not Epub
Abstract:
Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance...
Link:
https://www.nature.com/articles/s41392-020-00375-5
Organism or Cell Type:
cell culture: HepG2-SR
Citation Extract:
Xu J, Ji L, Liang Y, Wan Z, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, Chen J, Jin RA, Liang X, Cai X. CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 2020 Dec 26;5(1):298. doi: 10.1038/s41392-020-00375-5.

ace2 expression is higher in intestines and liver while being tightly regulated in development and disease in zebrafish

Authors:
Ayse Gokce Keskus, Melike Tombaz, Burcin I. Arici, Fatma B. Dincaslan, Afshan Nabi, Huma Shehwana, Ozlen Konu
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.24.424209
Epub:
Not Epub
Abstract:
Human Angiotensin I Converting Enzyme 2 (ACE2) that acts as a receptor for SARS-CoV-2 entry is highly expressed in human type...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.24.424209v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ayse Gokce Keskus, Melike Tombaz, Burcin I. Arici, Fatma B. Dincaslan, Afshan Nabi, Huma Shehwana, Ozlen Konu. ace2 expression is higher in intestines and liver while being tightly regulated in development and disease in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.24.424209.

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