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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos

Authors:
Ketharnathan S, Labudina A, Horsfield JA
Citation:
Front Cell Dev Biol. 2020;8:1542. doi:10.3389/fcell.2020.617545
Epub:
Not Epub
Abstract:
Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3, and Rad21, and either Stag1 or Stag2. Normal...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.617545/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ketharnathan S, Labudina A, Horsfield JA. Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Front Cell Dev Biol. 2020;8:1542. doi:10.3389/fcell.2020.617545.

Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy

Authors:
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E; Eteplirsen Study Group and Telethon Foundation DMD Italian Network
Citation:
Ann Neurol. 2016 Feb;79(2):257-71. doi: 10.1002/ana.24555. Epub 2016 Jan 8
Epub:
Not Epub
Abstract:
Objective: To continue evaluation of the long-term efficacy and safety of eteplirsen, a phosphorodiamidate morpholino oligomer...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/ana.24555
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E; Eteplirsen Study Group and Telethon Foundation DMD Italian Network. Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy. Ann Neurol. 2016 Feb;79(2):257-71. doi: 10.1002/ana.24555. Epub 2016 Jan 8.

Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3

Authors:
Osborn DPS, Emrahi L, Clayton J, Tabrizi MT, Wan AYB, Maroofian R, Yazdchi M, Garcia MLE, Galehdari H, Hesse C, Shariati G, Mazaheri N, Sedaghat A, Goullée H, Laing N, Jamshidi Y, Tajsharghi H
Citation:
Genet Med. 2020 Dec 8. doi: 10.1038/s41436-020-01028-2. Online ahead of print
Epub:
Yes
Abstract:
Purpose: Variants in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, the...
Link:
https://www.nature.com/articles/s41436-020-01028-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Osborn DPS, Emrahi L, Clayton J, Tabrizi MT, Wan AYB, Maroofian R, Yazdchi M, Garcia MLE, Galehdari H, Hesse C, Shariati G, Mazaheri N, Sedaghat A, Goullée H, Laing N, Jamshidi Y, Tajsharghi H. Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3. Genet Med. 2020 Dec 8. doi: 10.1038/s41436-020-01028-2. Online ahead of print.

A role for Cep70 in centriole amplification in multiciliated cells

Authors:
Kim SK, Brotslaw E, Thome V, Mitchell J, Ventrella R, Collins C, Mitchell B
Citation:
Dev Biol. 2020;471:10-17. doi: 10.1016/j.ydbio.2020.11.011. Online ahead of print
Epub:
Not Epub
Abstract:
Centriole amplification in multiciliated cells occurs in a pseudo-cell cycle regulated process that typically utilizes a poorly...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620303092
Organism or Cell Type:
Xenopus
Citation Extract:
Kim SK, Brotslaw E, Thome V, Mitchell J, Ventrella R, Collins C, Mitchell B. A role for Cep70 in centriole amplification in multiciliated cells. Dev Biol. 2020;471:10-17. doi: 10.1016/j.ydbio.2020.11.011. Online ahead of print.

Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study

Authors:
Komaki H, Takeshima Y, Matsumura T, Ozasa S, Funato M, Takeshita E, Iwata Y, Yajima H, Egawa Y, Toramoto T, Tajima M, Takeda S
Citation:
Ann Clin Transl Neurol. 2020 Dec 7. doi: 10.1002/acn3.51235. Online ahead of print
Epub:
Yes
Abstract:
Objective: The novel morpholino antisense oligonucleotide viltolarsen targets exon 53 of the dystrophin gene, and could be an...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/acn3.51235
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Takeshima Y, Matsumura T, Ozasa S, Funato M, Takeshita E, Iwata Y, Yajima H, Egawa Y, Toramoto T, Tajima M, Takeda S. Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study. Ann Clin Transl Neurol. 2020 Dec 7. doi: 10.1002/acn3.51235. Online ahead of print.

Phages as immunomodulators and their promising use as anti-inflammatory agents in a cftr loss-of-function zebrafish model

Authors:
Cafora M, Brix A, Forti F, Loberto N, Aureli M, Briani F, Pistocchi A
Citation:
J Cyst Fibros. 2020;[Epub ahead of print] doi:10.1016/j.jcf.2020.11.017
Epub:
Yes
Abstract:
Cystic Fibrosis (CF), one of the most frequent hereditary diseases due to mutations in the CFTR gene, causes mortality in...
Link:
https://www.cysticfibrosisjournal.com/article/S1569-1993(20)30927-9/pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cafora M, Brix A, Forti F, Loberto N, Aureli M, Briani F, Pistocchi A. Phages as immunomodulators and their promising use as anti-inflammatory agents in a cftr loss-of-function zebrafish model. J Cyst Fibros. 2020;[Epub ahead of print] doi:10.1016/j.jcf.2020.11.017.

Using migrating cells as probes to illuminate features in live embryonic tissues

Authors:
Gross-Thebing S, Truszkowski L, Tenbrinck D, Sánchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Hüwel J, Gaede F, Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Muñoz A, Burger M, Raz E
Citation:
Sci Adv. 2020 Dec 4;6(49):eabc5546. doi: 10.1126/sciadv.abc5546. Print 2020 Dec
Epub:
Yes
Abstract:
The biophysical and biochemical properties of live tissues are important in the context of development and disease. Methods for...
Link:
https://advances.sciencemag.org/content/6/49/eabc5546
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gross-Thebing S, Truszkowski L, Tenbrinck D, Sánchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Hüwel J, Gaede F, Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Muñoz A, Burger M, Raz E. Using migrating cells as probes to illuminate features in live embryonic tissues. Sci Adv. 2020 Dec 4;6(49):eabc5546. doi: 10.1126/sciadv.abc5546. Print 2020 Dec.

Grb10a knockdown in Danio rerio during early life alters growth and cardiometabolic function associated with a remodelled transcriptome

Authors:
Evans B, Garner T, DeLeonibus C, Wearing O, Shiels H, Hurlstone AH, Clayton P, Stevens A
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.06.413633
Epub:
Not Epub
Abstract:
Embryonic growth trajectory is a risk factor for chronic metabolic and cardiovascular disorders and influences birth weight...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.06.413633v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Evans B, Garner T, DeLeonibus C, Wearing O, Shiels H, Hurlstone AH, Clayton P, Stevens A. Grb10a knockdown in Danio rerio during early life alters growth and cardiometabolic function associated with a remodelled transcriptome. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.06.413633.

Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish

Authors:
Huang C, Zhu B, Leng D, Ge W, Zhang XD
Citation:
FEBS Open Bio. 2021 Apr;11(4):1259-1276. doi: 10.1002/2211-5463.13057
Epub:
Not Epub
Abstract:
Y-box-binding protein 1 (Ybx1, YB-1), also known as Y-box transcription factor, is involved in a variety of biological...
Link:
https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13057
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Huang C, Zhu B, Leng D, Ge W, Zhang XD. Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish. FEBS Open Bio. 2021 Apr;11(4):1259-1276. doi: 10.1002/2211-5463.13057.

Systematic comparison of sea urchin and sea star developmental gene regulatory networks explains how novelty is incorporated in early development

Authors:
Cary GA, McCauley BS, Zueva O, Pattinato J, Longabaugh W, Hinman VF
Citation:
Nat Commun. 2020;11:6235. doi:10.1038/s41467-020-20023-4
Epub:
Not Epub
Abstract:
The extensive array of morphological diversity among animal taxa represents the product of millions of years of evolution....
Link:
https://www.nature.com/articles/s41467-020-20023-4
Delivery Method:
microinjection
Organism or Cell Type:
Patiria miniata (sea star)
Citation Extract:
Cary GA, McCauley BS, Zueva O, Pattinato J, Longabaugh W, Hinman VF. Systematic comparison of sea urchin and sea star developmental gene regulatory networks explains how novelty is incorporated in early development. Nat Commun. 2020;11:6235. doi:10.1038/s41467-020-20023-4.

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