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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia

Authors:
Wiessner M, Maroofian R, Ni M-Y, Pedroni A, Müller JS, Stucka R, Beetz C, Efthymiou S, Santorelli FM, Alfares AA, Zhu C, Uhrova MA, Alehabib E, Bakhtiari S, Janecke AR, Otero MG, Chen JYH, Peterson JT, Strom TM, De JP, Deconinck T, De Ridder W, De Winter J, Pasquariello R, Ricca I,Alfadhel M, van de Warrenburg BP, Portier R, Bergmann C, Ghasemi FS,Jin SC, Bilguvar K, Hamed S, Abdelhameed M, Haridy NA, Maqbool S, Rahman F, Anwar N, Carmichael J, Pagnamenta A, Wood NW, Tran Mau-Them F, Haack T, Genomics England Research Consortium PREPARE network, Di Rocco M, <authors deleted - database limit> Shamseldin H, Al Tala S, Rezazadeh VJ, Najafi M, Deschner S, Gläser D, Hüttel W, Kruer MC, Kamsteeg E-J, Takiyama Y, Züchner S, Baets J, Synofzik M, Schüle R, Horvath R, Houlden H, Bartesaghi L, Lee H-J, Ampatzis K, Pierson TM, Senderek J
Citation:
Brain. 2021;[Epub] doi:10.1093/brain/awab041
Epub:
Not Epub
Abstract:
Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity...
Link:
https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awab041/6273093
Organism or Cell Type:
zebrafish
Citation Extract:
Wiessner M, Maroofian R, Ni M-Y, Pedroni A, Müller JS, Stucka R, Beetz C, Efthymiou S, Santorelli FM, Alfares AA, Zhu C, Uhrova MA, Alehabib E, Bakhtiari S, Janecke AR, Otero MG, Chen JYH, Peterson JT, Strom TM, De JP, Deconinck T, De Ridder W, De Winter J, Pasquariello R, Ricca I,Alfadhel M, van de Warrenburg BP, Portier R, Bergmann C, Ghasemi FS,Jin SC, Bilguvar K, Hamed S, Abdelhameed M, Haridy NA, Maqbool S, Rahman F, Anwar N, Carmichael J, Pagnamenta A, Wood NW, Tran Mau-Them F, Haack T, Genomics England Research Consortium PREPARE network, Di Rocco M, <authors deleted - database limit> Shamseldin H, Al Tala S, Rezazadeh VJ, Najafi M, Deschner S, Gläser D, Hüttel W, Kruer MC, Kamsteeg E-J, Takiyama Y, Züchner S, Baets J, Synofzik M, Schüle R, Horvath R, Houlden H, Bartesaghi L, Lee H-J, Ampatzis K, Pierson TM, Senderek J. Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia. Brain. 2021;[Epub] doi:10.1093/brain/awab041.

Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo

Authors:
Molina MD, Lepage T
Citation:
Curr Top Dev Biol. 2020;140:283-316. doi: 10.1016/bs.ctdb.2019.10.007. Epub 2019 Nov 22
Epub:
Not Epub
Abstract:
Specification of the main axes of polarity of the embryo is an essential process during embryonic development. In many species...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0070215319300821
Organism or Cell Type:
sea urchin
Citation Extract:
Molina MD, Lepage T. Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo. Curr Top Dev Biol. 2020;140:283-316. doi: 10.1016/bs.ctdb.2019.10.007. Epub 2019 Nov 22.

Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate

Authors:
Chuykin I, Itoh K, Kim K, Sokol SY
Citation:
J Cell Sci. 2021 Dec 15;134(24):jcs258864. doi: 10.1242/jcs.258864. Epub 2021 Dec 15. PMID: 34806749; PMCID: PMC8729781
Epub:
Not Epub
Abstract:
The orientation of epithelial cells in the plane of the tissue, known as planar cell polarity (PCP), is regulated by...
Link:
https://journals.biologists.com/jcs/article/134/24/jcs258864/273708/Frizzled3-inhibits-Vangl2-Prickle3-association-to
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chuykin I, Itoh K, Kim K, Sokol SY. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate. J Cell Sci. 2021 Dec 15;134(24):jcs258864. doi: 10.1242/jcs.258864. Epub 2021 Dec 15. PMID: 34806749; PMCID: PMC8729781.

Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish

Authors:
Hung J-C, Wu J-L, Hong J-R
Citation:
Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832
Epub:
Not Epub
Abstract:
The BH3-only molecule Bad regulates cell death via its differential protein phosphorylation, but very few studies address its...
Link:
https://www.mdpi.com/1422-0067/22/9/4832
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hung J-C, Wu J-L, Hong J-R. Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832.

Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception

Authors:
Boutillon A, Escot S, Elouin A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB
Citation:
Dev Cell. 2022 Jun 20;57(12):1529-1544.e5. doi: 10.1016/j.devcel.2022.05.001. Epub 2022 May 24. PMID: 35613615
Epub:
Not Epub
Abstract:
Morphogenesis, wound healing, and some cancer metastases depend upon the migration of cell collectives that need to be guided...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00329-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boutillon A, Escot S, Elouin A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB. Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Dev Cell. 2022 Jun 20;57(12):1529-1544.e5. doi: 10.1016/j.devcel.2022.05.001. Epub 2022 May 24. PMID: 35613615.

Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway

Authors:
Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H
Citation:
Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print
Epub:
Yes
Abstract:
The focal adhesion protein Kindlin2 is essential for integrin activation, a process that is fundamental to cell-extracellular...
Link:
https://journals.biologists.com/dev/article/doi/10.1242/dev.199441/261719/Kindlin2-regulates-neural-crest-specification-via
Organism or Cell Type:
Xenopus
Citation Extract:
Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H. Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway. Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print.

A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis

Authors:
Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP
Citation:
J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print
Epub:
Yes
Abstract:
Context: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic...
Link:
https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab283/6257595
Organism or Cell Type:
zebrafish
Citation Extract:
Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP. A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print.

The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin

Authors:
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L
Citation:
Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5
Epub:
Not Epub
Abstract:
Dystrophin proteomic regulation in muscular dystrophies (MDs) remains unclear. We report that a long noncoding RNA (lncRNA),...
Link:
https://www.nature.com/articles/s41556-020-00595-5
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5.

Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm

Authors:
Bouldin CM, Manning AJ, Peng YH, Farr GH 3rd, Hung KL, Dong A, Kimelman D
Citation:
Development. 2015 Jul 15;142(14):2499-507. doi: 10.1242/dev.124024. Epub 2015 Jun 10
Epub:
Not Epub
Abstract:
Anterior to posterior growth of the vertebrate body is fueled by a posteriorly located population of bipotential neuro-...
Link:
https://journals.biologists.com/dev/article/142/14/2499/408/Wnt-signaling-and-tbx16-form-a-bistable-switch-to
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bouldin CM, Manning AJ, Peng YH, Farr GH 3rd, Hung KL, Dong A, Kimelman D. Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development. 2015 Jul 15;142(14):2499-507. doi: 10.1242/dev.124024. Epub 2015 Jun 10.

Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations

Authors:
Dulla K, Slijkerman R, van Diepen HC, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, Besten CD, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, de Vrieze E, van Wijk E
Citation:
Mol Ther. 2021;29(8)2441-55. doi: 10.1016/j.ymthe.2021.04.024. Online ahead of print
Epub:
Not Epub
Abstract:
Mutations in USH2A are among the most common causes of syndromic and non-syndromic retinitis pigmentosa (RP). The two most...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(21)00212-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dulla K, Slijkerman R, van Diepen HC, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, Besten CD, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, de Vrieze E, van Wijk E. Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations. Mol Ther. 2021;29(8)2441-55. doi: 10.1016/j.ymthe.2021.04.024. Online ahead of print.

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