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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish
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Citation:
Cells. 2021 Jan 22;10(2):221. doi: 10.3390/cells10020221 Epub:
Not Epub Abstract:
The "distal axonopathy" hypothesis in amyotrophic lateral sclerosis (ALS) proposes that pathological changes occur at... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Campanari ML, Marian A, Ciura S, Kabashi E. TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish. Cells. 2021 Jan 22;10(2):221. doi: 10.3390/cells10020221. |
The Axenfeld–Rieger Syndrome Gene FOXC1 Contributes to Left–Right Patterning
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Citation:
Genes. 2021;12(2):170. https://doi.org/10.3390/genes12020170 Epub:
Not Epub Abstract:
Precise spatiotemporal expression of the Nodal-Lefty-Pitx2 cascade in the lateral plate mesoderm establishes the left–right... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chrystal PW, French CR, Jean F, Havrylov S, van Baarle S, Peturson A-M, Xu P, Crump JG, Pilgrim DB, Lehmann OJ, Waskiewicz AJ. The Axenfeld–Rieger Syndrome Gene FOXC1 Contributes to Left–Right Patterning. Genes. 2021;12(2):170. https://doi.org/10.3390/genes12020170 . |
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants
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Citation:
Genet Med. 2021;[Epub ahead of print] doi:10.1038/s41436-020-01091-9 Epub:
Yes Abstract:
Purpose: To expand the recent description of a new neurodevelopmental syndrome related to alterations in CDK19.
Methods:... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zarate YA, Uehara T, Abe K, Oginuma M, Harako S, Ishitani S, Lehesjoki A-E, Bierhals T, Kloth K, Ehmke N, Horn D, Holtgrewe M, Anderson K, Viskochil D, Edgar-Zarate CL, Sacoto MJG, Schnur RE, Morrow MM, Sanchez-Valle A, Pappas J, Rabin R, Muona M, Anttonen A-K, Platzer K, Luppe J, Gburek-Augustat J, Kaname T, Okamoto N, Mizuno S, Kaido Yusaku, Ohkuma Y, Hirose Y, Ishitani T, Kosaki K. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants. Genet Med. 2021;[Epub ahead of print] doi:10.1038/s41436-020-01091-9. |
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds
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Citation:
Development. 2021;148:dev1905008 doi:10.1242/dev.195008 Epub:
Yes Abstract:
Pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs)... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K. Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. Development. 2021;148:dev1905008 doi:10.1242/dev.195008. |
Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing
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Citation:
bioRxiv. 2020;[preprint] doi: https://doi.org/10.1101/527002 Epub:
Not Epub Abstract:
The Krüppel-like factor (Klf) gene family encodes for transcription factors that play an important role in the regulation of... Delivery Method:
microinjection Organism or Cell Type:
Mnemiopsis leidyi (ctenophore) Citation Extract: Presnell JS, Browne WE. Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing. bioRxiv. 2020;[preprint] doi: https://doi.org/10.1101/527002 . |
Somite surface tension buffers imprecise segment lengths to ensure left-right symmetry
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251645 Epub:
Not Epub Abstract:
The body axis of vertebrate embryos is periodically segmented into bilaterally symmetric pairs of somites. The anteroposterior... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Naganathan SR, Popović M, Oates AC. Somite surface tension buffers imprecise segment lengths to ensure left-right symmetry. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251645 . |
The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.15.422833 Epub:
Not Epub Abstract:
The zinc finger transcription factor Snai1 is a well-known regulator of epithelial-to-mesenchymal transition (EMT)1, 2; it is... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gentile A, Bensimon-Brito A, Priya R, Maischein H-M, Piesker J, Günther S, Gunawan F, Stainier DYR. The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.15.422833 . |
Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience
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Citation:
Neuron. 2021;[Epub ahead of print] doi:10.1016/j.neuron.2021.01.002 Epub:
Yes Abstract:
Gene Ontology analyses of autism spectrum disorders (ASD) risk genes have repeatedly highlighted synaptic function and... Organism or Cell Type:
Xenopus tropicalis Citation Extract: Willsey HR, Exner CRT, Xu Y, Everitt A, Sun N, Wang B, Dea J, Schmunk G, Zaltsman Y, Teerikorpi N, Kim A, Anderson AS, Shin D, Seyler M, Nowakowski TJ, Harland RM, Willsey AJ, State MW. Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience. Neuron. 2021;[Epub ahead of print] doi:10.1016/j.neuron.2021.01.002. |
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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Citation:
Cell. 2021;184:[Epub ahead of print] doi:10.1016/j.cell.2020.12.024 Epub:
Yes Abstract:
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Prentzell MT, Rehbein U, Sandoval MC, De Meulemeester A-S, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Pittol JMR, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021;184:[Epub ahead of print] doi:10.1016/j.cell.2020.12.024. |
Anterior lateral plate mesoderm gives rise to multiple tissues and requires tbx5a function in left-right asymmetry, migration dynamics, and cell specification of late-addition cardiac cells
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Citation:
Dev Biol. 2021;472:52-66. doi:10.1016/j.ydbio.2021.01.007 Epub:
Not Epub Abstract:
In this study, we elucidate a single cell resolution fate map in the zebrafish in a sub-section of the anterior Lateral Plate... Organism or Cell Type:
zebrafish Citation Extract: Mao LMF, Boyle Anderson EAT, Ho RK. Anterior lateral plate mesoderm gives rise to multiple tissues and requires tbx5a function in left-right asymmetry, migration dynamics, and cell specification of late-addition cardiac cells. Dev Biol. 2021;472:52-66. doi:10.1016/j.ydbio.2021.01.007. |