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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation

Authors:
Azambuja AP, Simoes-Costa M
Citation:
PLoS Genet. 2021;17(1):e1009296. doi:10.1371/journal.pgen.1009296
Epub:
Not Epub
Abstract:
The process of cell fate commitment involves sequential changes in the gene expression profiles of embryonic progenitors. This...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009296
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Azambuja AP, Simoes-Costa M. A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation. PLoS Genet. 2021;17(1):e1009296. doi:10.1371/journal.pgen.1009296.

Systemic antisense therapeutics inhibiting DUX4 expression improves muscle function in an FSHD mouse model

Authors:
Lu-Nguyen N, Malerba A, Dickson G, Popplewell L
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.01.14.426659
Epub:
Not Epub
Abstract:
Aberrant expression of the double homeobox 4 (DUX4) gene in skeletal muscle causes muscle deterioration and weakness in...
Link:
https://www.biorxiv.org/content/10.1101/2021.01.14.426659v1
Delivery Method:
Endo-Porter, Vivo-Morpholino
Organism or Cell Type:
cell culture, mice
Citation Extract:
Lu-Nguyen N, Malerba A, Dickson G, Popplewell L. Systemic antisense therapeutics inhibiting DUX4 expression improves muscle function in an FSHD mouse model. bioRxiv. 2021;[preprint] doi:10.1101/2021.01.14.426659.

The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus

Authors:
Bhuiyan MS, Jiang J-H, Kostoulias X, Theegala R, Lieschke GJ, Peleg AY
Citation:
Antibiotics. 2021;10(2):96. doi:10.3390/antibiotics10020096
Epub:
Not Epub
Abstract:
Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of...
Link:
https://www.mdpi.com/2079-6382/10/2/96
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bhuiyan MS, Jiang J-H, Kostoulias X, Theegala R, Lieschke GJ, Peleg AY. The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus. Antibiotics. 2021;10(2):96. doi:10.3390/antibiotics10020096.

Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish

Authors:
Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N
Citation:
Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z
Epub:
Not Epub
Abstract:
The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans,...
Link:
https://www.nature.com/articles/s41419-020-03359-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z.

Rab11fip5 regulates telencephalon development via ephrinB1 recycling

Authors:
Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Citation:
Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print
Epub:
Yes
Abstract:
Rab11 family-interacting protein 5 (Rab11fip5) is an adaptor protein that binds to the small GTPase Rab11, which has an...
Link:
https://dev.biologists.org/content/early/2021/01/15/dev.196527
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO. Rab11fip5 regulates telencephalon development via ephrinB1 recycling. Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print.

Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish

Authors:
Lu S, Lyu Z, Wang Z, Kou Y, Liu C, Li S, Hu M, Zhu H, Wang W, Zhang C, Kuan YS, Liu YW, Chen J, Tian J
Citation:
Theranostics. 2021 Jan 1;11(6):2788-2805. doi: 10.7150/thno.53330. eCollection 2021
Epub:
Not Epub
Abstract:
Lipin 1 is an intracellular protein acting as a phosphatidic acid phosphohydrolase enzyme controlling lipid metabolism. Human...
Link:
https://www.thno.org/v11p2788.htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu S, Lyu Z, Wang Z, Kou Y, Liu C, Li S, Hu M, Zhu H, Wang W, Zhang C, Kuan YS, Liu YW, Chen J, Tian J. Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 2021 Jan 1;11(6):2788-2805. doi: 10.7150/thno.53330. eCollection 2021.

Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish

Authors:
Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW
Citation:
J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print
Epub:
Yes
Abstract:
Aims/introduction: β-cell dysfunction is a hallmark of type 2 diabetes. In a previous pilot study, we identified an association...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/jdi.13503
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW. Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print.

Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice

Authors:
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G
Citation:
Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print
Epub:
Yes
Abstract:
Genetic programs underlying preimplantation development and early lineage segregation are highly conserved across mammals. It...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.295
Organism or Cell Type:
cynomolgus monkey embryo
Citation Extract:
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G. Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice. Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print.

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

Authors:
Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ
Citation:
Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J
Epub:
Not Epub
Abstract:
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne...
Link:
https://pubs.rsc.org/en/content/articlelanding/2016/ob/c6ob00007j
Citation Extract:
Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ. Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition. Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J.

Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions

Authors:
Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J
Citation:
Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011
Epub:
Not Epub
Abstract:
The posterior lateral line system (pLLS) of aquatic animals comprises small clustered mechanosensory organs along the side of...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.591011/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J. Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011 .

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