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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis

Authors:
Chambers JM, Addiego A, Flores-Mireles AL, Wingert RA
Citation:
Cell Rep. 2020;22(6):108370. doi:10.1016/j.celrep.2020.108370
Epub:
Not Epub
Abstract:
Cilia are microtubule-based organelles that function in a multitude of physiological contexts to perform chemosensing,...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31359-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers JM, Addiego A, Flores-Mireles AL, Wingert RA. Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis. Cell Rep. 2020;22(6):108370. doi:10.1016/j.celrep.2020.108370.

AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation

Authors:
Kang JW, Kim Y, Lee Y, Myung K, Kim YH, Oh CK
Citation:
J Cell Biochem. 2020 Nov 9. doi: 10.1002/jcb.29869. Online ahead of print
Epub:
Yes
Abstract:
Acute myeloid leukaemia (AML) is a blood cancer where undifferentiated myeloid cells are increased in the bone marrow and...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.29869
Organism or Cell Type:
zebrafish
Citation Extract:
Kang JW, Kim Y, Lee Y, Myung K, Kim YH, Oh CK. AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation. J Cell Biochem. 2020 Nov 9. doi: 10.1002/jcb.29869. Online ahead of print.

A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis

Authors:
Freire C, Fish RJ, Vilar R, Di Sanza C, Grzegorski SJ, Richter CE, Shavit JA, Neerman-Arbez M
Citation:
Blood Adv. 2020;4(21):5480–5491. doi:10.1182/bloodadvances.2020001472
Epub:
Not Epub
Abstract:
Plasma fibrinogen molecules comprise 2 copies of Aα, Bβ, and γ chains folded into a hexameric protein. A minor fibrinogen...
Link:
https://ashpublications.org/bloodadvances/article/4/21/5480/474105/A-genetic-modifier-of-venous-thrombosis-in
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Freire C, Fish RJ, Vilar R, Di Sanza C, Grzegorski SJ, Richter CE, Shavit JA, Neerman-Arbez M. A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis. Blood Adv. 2020;4(21):5480–5491. doi:10.1182/bloodadvances.2020001472.

MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome

Authors:
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A
Citation:
Nat Genet. 2020;[Epub ahead of print]. doi:10.1038/s41588-020-00724-8
Epub:
Yes
Abstract:
The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin...
Link:
https://www.nature.com/articles/s41588-020-00724-8
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A. MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome. Nat Genet. 2020;[Epub ahead of print]. doi:10.1038/s41588-020-00724-8.

A generic assay for the identification of splicing variants that induce nonsense-mediated decay in Pompe disease

Authors:
Bergsma AJ, in ’t Groen SLM, Catalano F, Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT, Pijnappel WWMP
Citation:
Eur J Hum Genet. 2020;{Epub ahead of print]. doi:10.1038/s41431-020-00751-3
Epub:
Yes
Abstract:
DNA variants affecting mRNA expression and processing in genetic diseases are often missed or poorly characterized. We...
Link:
https://www.nature.com/articles/s41431-020-00751-3
Delivery Method:
Endo-Porter DMSO
Organism or Cell Type:
cell culture: human primary fibroblasts
Citation Extract:
Bergsma AJ, in ’t Groen SLM, Catalano F, Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT, Pijnappel WWMP. A generic assay for the identification of splicing variants that induce nonsense-mediated decay in Pompe disease. Eur J Hum Genet. 2020;{Epub ahead of print]. doi:10.1038/s41431-020-00751-3.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

Authors:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460
Epub:
Yes
Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health....
Link:
https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkaa460/5961620
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers. J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460.

Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells

Authors:
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón N-A, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E
Citation:
Immunity. 2020;[Epub ahead of print] doi:10.1016/j.immuni.2020.10.007
Epub:
Yes
Abstract:
Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC) development. Here, we studied the...
Link:
https://www.cell.com/immunity/pdf/S1074-7613(20)30448-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón N-A, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E. Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 2020;[Epub ahead of print] doi:10.1016/j.immuni.2020.10.007.

Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos

Authors:
Ketharnathan S, Labudina A, Horsfield JA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.19.346122
Epub:
Not Epub
Abstract:
Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3 and Rad21, and either Stag1 or Stag2. Normal...
Link:
https://www.biorxiv.org/content/10.1101/2020.10.19.346122v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ketharnathan S, Labudina A, Horsfield JA. Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.19.346122.

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification

Authors:
Hutchins EJ, Chacon J, Bronner ME
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.14.338715
Epub:
Not Epub
Abstract:
Neural crest development is transcriptionally controlled via sequential activation of gene regulatory networks (GRNs). Recent...
Link:
https://www.biorxiv.org/content/10.1101/2020.10.14.338715v1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Hutchins EJ, Chacon J, Bronner ME. RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.14.338715 .

hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development

Authors:
Ye Z, Kimelman D
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.185298
Epub:
Yes
Abstract:
The early vertebrate embryo extends from anterior to posterior due to the addition of neural and mesodermal cells from a...
Link:
https://dev.biologists.org/content/early/2020/11/03/dev.185298
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ye Z, Kimelman D. hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development. 2020;[Epub ahead of print] doi:10.1242/dev.185298.

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