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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model

Authors:
Arogbokun O, Shevik M, Slusher T, Farouk Z, Elfstrum A, Weber J, Cusick SE, Lund T
Citation:
Sci Rep. 2020;10(1):19172 doi:10.1038/s41598-020-75823-x
Epub:
Not Epub
Abstract:
Traditional remedies are widely used throughout Africa in routine care for infants. However, such remedies could have...
Link:
https://www.nature.com/articles/s41598-020-75823-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arogbokun O, Shevik M, Slusher T, Farouk Z, Elfstrum A, Weber J, Cusick SE, Lund T. Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Sci Rep. 2020;10(1):19172 doi:10.1038/s41598-020-75823-x.

A serpin is required for ectomesoderm, a hallmark of spiralian development

Authors:
Wu L, Lambert JD
Citation:
Dev Biol. 2020 Oct 24:S0012-1606(20)30282-7. doi: 10.1016/j.ydbio.2020.10.011. Online ahead of print
Epub:
Yes
Abstract:
Among animals, diploblasts contain two germ layers, endoderm and ectoderm, while triploblasts have a distinct third germ layer...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620302827
Delivery Method:
microinjection
Organism or Cell Type:
Tritia obsoleta (previously Ilyanassa obsoleta) gastropod
Citation Extract:
Wu L, Lambert JD. A serpin is required for ectomesoderm, a hallmark of spiralian development. Dev Biol. 2020 Oct 24:S0012-1606(20)30282-7. doi: 10.1016/j.ydbio.2020.10.011. Online ahead of print.

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

Authors:
Lee H, Seidl C, Sun R, Glinka A, Niehrs C
Citation:
Nat Commun. 2020;11:5570. doi:10.1038/s41467-020-19373-w
Epub:
Not Epub
Abstract:
BMP signaling plays key roles in development, stem cells, adult tissue homeostasis, and disease. How BMP receptors are...
Link:
https://www.nature.com/articles/s41467-020-19373-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H, Seidl C, Sun R, Glinka A, Niehrs C. R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun. 2020;11:5570. doi:10.1038/s41467-020-19373-w.

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency

Authors:
Diofano F, Weinmann K, Schneider I, Thiessen KD, Rottbauer W, Just S
Citation:
PLoS Genet. 2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088. eCollection 2020 Nov
Epub:
Not Epub
Abstract:
Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM),...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009088
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Diofano F, Weinmann K, Schneider I, Thiessen KD, Rottbauer W, Just S. Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency. PLoS Genet. 2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088. eCollection 2020 Nov.

TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

Authors:
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Gabriele Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.27.356782
Epub:
Not Epub
Abstract:
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5’ mono-methylguanosine cap of snRNAs to a...
Link:
https://www.biorxiv.org/content/10.1101/2020.10.27.356782v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Gabriele Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD. TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.27.356782.

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

Authors:
Reis AH, Sokol SY
Citation:
bioRxiv. 2020;[preprint] doi:/10.1101/2020.10.30.362541
Epub:
Not Epub
Abstract:
The Wnt pathway activates target genes by controlling the b-catenin-T-cell factor (TCF) transcriptional complex during...
Link:
https://www.biorxiv.org/content/10.1101/2020.10.30.362541v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Reis AH, Sokol SY. Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. bioRxiv. 2020;[preprint] doi:/10.1101/2020.10.30.362541 .

Uncovering the mesendoderm gene regulatory network through multi-omic data integration

Authors:
Jansen C, Paraiso K, Zhou J, Blitz IL, Fish M, Charney R, Cho JS, Yasuoka Y, Sudou N, Bright AR, Wlizla M, Veenstra GJC, Taira M, Zorn A, Mortazavi A, Cho KWY
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.01.362053
Epub:
Not Epub
Abstract:
Mesendodermal specification is one of the earliest events in embryogenesis, where cells first acquire distinct identities. Cell...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.01.362053v1
Organism or Cell Type:
Xenopus
Citation Extract:
Jansen C, Paraiso K, Zhou J, Blitz IL, Fish M, Charney R, Cho JS, Yasuoka Y, Sudou N, Bright AR, Wlizla M, Veenstra GJC, Taira M, Zorn A, Mortazavi A, Cho KWY. Uncovering the mesendoderm gene regulatory network through multi-omic data integration. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.01.362053.

Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish

Authors:
Khandekar G, Iyer N, Jagadeeswaran P
Citation:
Res Pract Thromb Haemost. 2020 Sep 22;4(7):1150-1157. doi: 10.1002/rth2.12428. eCollection 2020 Oct
Epub:
Not Epub
Abstract:
Background: Blood clotting in humans is initiated by the binding of tissue factor to activated coagulation factor VII (FVIIa)...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/rth2.12428
Delivery Method:
Vivo-Morpholino (piggyback)
Organism or Cell Type:
zebrafish
Citation Extract:
Khandekar G, Iyer N, Jagadeeswaran P. Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish. Res Pract Thromb Haemost. 2020 Sep 22;4(7):1150-1157. doi: 10.1002/rth2.12428. eCollection 2020 Oct.

Influence of astrocytic glutamine transporter SN1 deficiency on electrophysiological correlates of glutamatergic transmission

Authors:
Popek M, Bobula B, Sowa J, Hess G, Albrecht J, Zielinska M
Citation:
J Neurochem. 2017; 142(suppl 1):125. doi:10.1111/jnc.14093
Epub:
Not Epub
Abstract:
The N-system glutamine transporter SN1 preferentially transfers glutamine out of astrocytes (Chaudhry et al., Cell 1999), and...
Link:
https://air.unimi.it/retrieve/handle/2434/770281/1576051/jnc.14093.pdf
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Popek M, Bobula B, Sowa J, Hess G, Albrecht J, Zielinska M. Influence of astrocytic glutamine transporter SN1 deficiency on electrophysiological correlates of glutamatergic transmission. J Neurochem. 2017; 142(suppl 1):125. doi:10.1111/jnc.14093.

Phosphatidylinositol 4 kinase-β mutations cause non-syndromic sensorineural deafness and inner ear malformation

Authors:
Su X, Feng Y, Rahman SA, Wu S, Li G, Rüschendorf F, Zhao L, Cui H, Liang J, Fang L, Hu H, Froehler S, Yu Y, Patone G, Hummel O, Chen Q, Raile K, Luft FC, Bähring S, Hussain K, Chen W, Zhang J, Gong
Citation:
J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2020.07.008
Epub:
Yes
Abstract:
Congenital hearing loss is a common disorder worldwide. Heterogeneous gene variation accounts for approximately 20% - 25% of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1673852720301648
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Su X, Feng Y, Rahman SA, Wu S, Li G, Rüschendorf F, Zhao L, Cui H, Liang J, Fang L, Hu H, Froehler S, Yu Y, Patone G, Hummel O, Chen Q, Raile K, Luft FC, Bähring S, Hussain K, Chen W, Zhang J, Gong. Phosphatidylinositol 4 kinase-β mutations cause non-syndromic sensorineural deafness and inner ear malformation. J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2020.07.008.

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