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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord

Authors:
Tsata V, Möllmert S, Schweitzer C, Kolb J, Möckel C, Böhm B, Rosso G, Lange C, Lesche M, Hammer J, Kesavan G, Beis D, Guck J, Brand M, Wehner D
Citation:
Dev Cell. 2021;[Epub ahead of print] doi:10.1016/j.devcel.2020.12.009
Epub:
Not Epub
Abstract:
In mammals, perivascular cell-derived scarring after spinal cord injury impedes axonal regrowth. In contrast, the extracellular...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30984-9
Delivery Method:
Vivo-Morpholino pericardial vein injection
Organism or Cell Type:
zebrafish
Citation Extract:
Tsata V, Möllmert S, Schweitzer C, Kolb J, Möckel C, Böhm B, Rosso G, Lange C, Lesche M, Hammer J, Kesavan G, Beis D, Guck J, Brand M, Wehner D. A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Dev Cell. 2021;[Epub ahead of print] doi:10.1016/j.devcel.2020.12.009.

Ectoderm to mesoderm transition by down-regulation of actomyosin contractility

Authors:
Kashkooli L, Rozema D, Espejo-Ramirez L, Lasko P, Fagotto F
Citation:
PLoS Biol. 2021;19(1):e3001060. doi:10.1371/journal.pbio.3001060
Epub:
Not Epub
Abstract:
Collective migration of cohesive tissues is a fundamental process in morphogenesis and is particularly well illustrated during...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001060
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kashkooli L, Rozema D, Espejo-Ramirez L, Lasko P, Fagotto F. Ectoderm to mesoderm transition by down-regulation of actomyosin contractility. PLoS Biol. 2021;19(1):e3001060. doi:10.1371/journal.pbio.3001060.

The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy

Authors:
Scaglioni D, Catapano F, Ellis M, Torelli S, Chambers D, Feng L, Beck M, Sewry C, Monforte M, Harriman S, Koenig E, Malhotra J, Popplewell L, Guglieri M, Straub V, Mercuri E, Servais L, Phadke R, Morgan J, Muntoni F
Citation:
Acta Neuropathol Commun. 2021 Jan 6;9(1):7. doi: 10.1186/s40478-020-01106-1
Epub:
Not Epub
Abstract:
During the last decade, multiple clinical trials for Duchenne muscular dystrophy (DMD) have focused on the induction of...
Link:
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-01106-1
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Scaglioni D, Catapano F, Ellis M, Torelli S, Chambers D, Feng L, Beck M, Sewry C, Monforte M, Harriman S, Koenig E, Malhotra J, Popplewell L, Guglieri M, Straub V, Mercuri E, Servais L, Phadke R, Morgan J, Muntoni F. The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy. Acta Neuropathol Commun. 2021 Jan 6;9(1):7. doi: 10.1186/s40478-020-01106-1.

Leucyl-tRNA Synthetase Deficiency Systemically Induces Excessive Autophagy in Zebrafish

Authors:
Shiraishi H, Shimizu N, Tsumori M, Kiyota K, Maeda M, Ishitani T, Hanada R, Ihara K, Hanada T, Inoue M, Miyahara H
Citation:
Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-132893/v1
Epub:
Not Epub
Abstract:
Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to...
Link:
https://www.researchsquare.com/article/rs-132893/v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shiraishi H, Shimizu N, Tsumori M, Kiyota K, Maeda M, Ishitani T, Hanada R, Ihara K, Hanada T, Inoue M, Miyahara H. Leucyl-tRNA Synthetase Deficiency Systemically Induces Excessive Autophagy in Zebrafish. Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-132893/v1.

Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity

Authors:
Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L
Citation:
Cell Rep. 2021;34(1):108600. doi:10.1016/j.celrep.2020.108600
Epub:
Not Epub
Abstract:
Microgravity is a major environmental factor of space flight that triggers dysregulation of the immune system and increases...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31589-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L. Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity. Cell Rep. 2021;34(1):108600. doi:10.1016/j.celrep.2020.108600.

Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor

Authors:
Williams III CH, Neitzel LR, Karki P, Thayer TE, Keyesr BD, Wells QS, Perry JA, Birukov K, Birukova A, Hong CC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/612549
Epub:
Not Epub
Abstract:
An acidic milieu is a hallmark of the glycolytic metabolism that occurs in cancerous cells. The acidic environment is known to...
Link:
https://www.biorxiv.org/content/10.1101/612549v3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Williams III CH, Neitzel LR, Karki P, Thayer TE, Keyesr BD, Wells QS, Perry JA, Birukov K, Birukova A, Hong CC. Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor. bioRxiv. 2020;[preprint] doi:10.1101/612549.

12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

Authors:
Kulkarni A, Pineros AR, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Walsh M, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.01.02.424855
Epub:
Not Epub
Abstract:
Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1...
Link:
https://www.biorxiv.org/content/10.1101/2021.01.02.424855v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kulkarni A, Pineros AR, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Walsh M, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM. 12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes. bioRxiv. 2021;[preprint] doi:10.1101/2021.01.02.424855 .

Time-dependent pleiotropic phenotypes are caused by progressive DNA polymerase α deficiency in zebrafish

Authors:
Lin AY-S, Thomas GK, Ang K, van Rossum DB, Canfield VA, Cheng IKC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.31.425001
Epub:
Not Epub
Abstract:
The mechanisms underlying variation in cell- and tissue-specific phenotypes caused by mutations are poorly understood. For...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.31.425001v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin AY-S, Thomas GK, Ang K, van Rossum DB, Canfield VA, Cheng IKC. Time-dependent pleiotropic phenotypes are caused by progressive DNA polymerase α deficiency in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.31.425001.

Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis

Authors:
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L
Citation:
Hum Genet. 2021 Jan 4. doi: 10.1007/s00439-020-02243-2. Online ahead of print
Epub:
Yes
Abstract:
PIGK gene, encoding a key component of glycosylphosphatidylinositol (GPI) transamidase, was recently reported to be associated...
Link:
https://link.springer.com/article/10.1007%2Fs00439-020-02243-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L. Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis. Hum Genet. 2021 Jan 4. doi: 10.1007/s00439-020-02243-2. Online ahead of print.

HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function

Authors:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M
Citation:
Oxid Med Cell Longev. 2020;[Epub] doi:10.1155/2020/8706898
Epub:
Yes
Abstract:
Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals. HSP60 is a highly conserved stress protein...
Link:
https://www.hindawi.com/journals/omcl/2020/8706898/
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M. HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function. Oxid Med Cell Longev. 2020;[Epub] doi:10.1155/2020/8706898.

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