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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12156 scientific papers returned from the database with the search filters currently being used below.
There are 12156 scientific papers returned from the database with the search filters currently being used below.
Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
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Citation:
Front Chem. 2021;9:9. doi:10.3389/fchem.2021.627329 Epub:
Not Epub Abstract:
Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: spinal muscular atrophy (SMA) patient fibroblasts Citation Extract: Dastpeyman M, Karas JA, Amin A, Turner BJ, Shabanpoor F. Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation. Front Chem. 2021;9:9. doi:10.3389/fchem.2021.627329. |
hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies
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Citation:
Muscle Nerve. 2021 Mar 2. doi: 10.1002/mus.27216. Online ahead of print Epub:
Yes Abstract:
Introduction/aims: RNA binding proteins (RBPs) play an important role in skeletal muscle development and disease by regulating... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Alexander MS, Hightower RM, Reid AL, Bennett AH, Iyer L, Slonim DK, Saha M, Kawahara G, Kunkel LM, Kopin AS, Gupta VA, Kang PB, Draper I. hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies. Muscle Nerve. 2021 Mar 2. doi: 10.1002/mus.27216. Online ahead of print. |
Tdrd3 regulates the progression of meiosis II through translational control of Emi2 mRNA in mouse oocytes
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Citation:
Current Research in Cell Biology, Volume 2, 2021, 100009, ISSN 2590-2636, https://doi.org/10.1016/j.crcbio.2021.100009 Epub:
Not Epub Abstract:
After completion of meiosis I, the oocyte immediately enters meiosis II and forms a metaphase II (MII) spindle without an... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Takei N, Sato K, Takada Y, Iyyappan R, Susor A, Yamamoto T, Kotani T. Tdrd3 regulates the progression of meiosis II through translational control of Emi2 mRNA in mouse oocytes. Current Research in Cell Biology, Volume 2, 2021, 100009, ISSN 2590-2636, https://doi.org/10.1016/j.crcbio.2021.100009. |
Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos
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Citation:
iScience. 2023 Sep 9;26(10):107864. doi: 10.1016/j.isci.2023.107864. PMID: 37766982; PMCID: PMC10520531 Epub:
Not Epub Abstract:
The left-right symmetry breaking of vertebrate embryos requires nodal flow. However, the molecular mechanisms that mediate the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Du J, Li SK, Guan LY, Guo Z, Yin JF, Gao L, Kawanishi T, Shimada A, Zhang QP, Zheng LS, Liu YY, Feng XQ, Zhao L, Chen DY, Takeda H, Fan YB. Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos. iScience. 2023 Sep 9;26(10):107864. doi: 10.1016/j.isci.2023.107864. PMID: 37766982; PMCID: PMC10520531. |
Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
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Citation:
Elife. 2021 Aug 27;10:e66483. doi: 10.7554/eLife.66483. PMID: 34448451; PMCID: PMC8460252 Epub:
Not Epub Abstract:
The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg CP, Concha ML. Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. Elife. 2021 Aug 27;10:e66483. doi: 10.7554/eLife.66483. PMID: 34448451; PMCID: PMC8460252. |
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production
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Citation:
Dev Cell. 2021 Mar 8;56(5):627-640.e5. doi: 10.1016/j.devcel.2021.02.006. Epub 2021 Mar 1 Epub:
Yes Abstract:
Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and are essential for sustaining the blood... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Weinreb JT, Ghazale N, Pradhan K, Gupta V, Potts KS, Tricomi B, Daniels NJ, Padgett RA, De Oliveira S, Verma A, Bowman TV. Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Dev Cell. 2021 Mar 8;56(5):627-640.e5. doi: 10.1016/j.devcel.2021.02.006. Epub 2021 Mar 1. |
Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
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Citation:
Nucl Acids Res. 2021;gkab118. doi:10.1093/nar/gkab118 Epub:
Not Epub Abstract:
Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by the major and minor spliceosomes... Delivery Method:
electroporation Organism or Cell Type:
cell culture: HEK293T Citation Extract: Olthof AM, White AK, Mieruszynski S, Doggett K, Lee MF, Chakroun A, Abdel Aleem AK, Rousseau J, Magnani C, Roifman CM, Campeau PM, Heath JK, Kanadia RN. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Nucl Acids Res. 2021;gkab118. doi:10.1093/nar/gkab118. |
Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides
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Citation:
Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print Epub:
Yes Abstract:
Antisense oligonucleotides (ASOs) are an emerging class of gene-specific therapeutics for diseases associated with the central... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Dastpeyman M, Sharifi R, Amin A, Karas JA, Cuic B, Pan Y, Nicolazzo JA, Turner BJ, Shabanpoor F. Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides. Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print. |
Expression and Functional Analyses of Ectodermal Transcription Factors FoxJ-r, SoxF, and SP8/9 in Early Embryos of the Ascidian Halocynthia roretzi
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Citation:
Zoolog Sci. 2021 Feb;38(1):26-35. doi: 10.2108/zs200128 Epub:
Not Epub Abstract:
The spatiotemporal expression of zygotic genes is regulated by transcription factors, which mediate cell fate decision and... Delivery Method:
microinjection Organism or Cell Type:
Halocynthia roretzi (ascidian) Citation Extract: Shih Y, Wang K, Kumano G, Nishida H. Expression and Functional Analyses of Ectodermal Transcription Factors FoxJ-r, SoxF, and SP8/9 in Early Embryos of the Ascidian Halocynthia roretzi. Zoolog Sci. 2021 Feb;38(1):26-35. doi: 10.2108/zs200128. |
Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways
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Citation:
Biology Open. 2021;10:bio050096 doi:10.1242/bio.050096 Epub:
Not Epub Abstract:
The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li GX, Zhang S, Liu R, Singh B, Singh S, Quinn DI, Crump G, Gill PS. Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 2021;10:bio050096 doi:10.1242/bio.050096. |