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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

Authors:
Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, Sawa A, Wetsel WC, Werge T, Katsanis N
Citation:
Nat Comm. 2020;11:5903. doi:10.1038/s41467-020-19637-5
Epub:
Not Epub
Abstract:
The neuronal primary cilium and centriolar satellites have functions in neurogenesis, but little is known about their roles in...
Link:
https://www.nature.com/articles/s41467-020-19637-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, Sawa A, Wetsel WC, Werge T, Katsanis N. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Nat Comm. 2020;11:5903. doi:10.1038/s41467-020-19637-5.

Tension heterogeneity directs form and fate to pattern the myocardial wall

Authors:
Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein H-M, Stainier DYR
Citation:
Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2946-9
Epub:
Yes
Abstract:
How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the...
Link:
https://www.nature.com/articles/s41586-020-2946-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein H-M, Stainier DYR. Tension heterogeneity directs form and fate to pattern the myocardial wall. Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2946-9.

RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish

Authors:
Raman R, Ryon M, Jagadeeswaran P
Citation:
Sci Rep. 2020;10:20187 doi:10.1038/s41598-020-76655-5
Epub:
Not Epub
Abstract:
We recently developed a piggyback knockdown method that was used to knockdown genes in adult zebrafish. In this method, a vivo...
Link:
https://www.nature.com/articles/s41598-020-76655-5
Delivery Method:
Vivo-Morpholino (piggyback )
Organism or Cell Type:
zebrafish
Citation Extract:
Raman R, Ryon M, Jagadeeswaran P. RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Sci Rep. 2020;10:20187 doi:10.1038/s41598-020-76655-5.

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

Authors:
Parshina EA, Eroshkin FM, Оrlov EE, Gyoeva FK, Shokhina AG, Staroverov DB, Belousov VV, Zhigalova NA, Prokhortchouk EB, Zaraisky AG, Martynova NY
Citation:
Cell Rep. 2020;33(7):108396. doi:10.1016/j.celrep.2020.108396
Epub:
Not Epub
Abstract:
Zyxin is a cytoskeletal LIM-domain protein that regulates actin cytoskeleton assembly and gene expression. In the present work...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31385-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis and zebrafish
Citation Extract:
Parshina EA, Eroshkin FM, Оrlov EE, Gyoeva FK, Shokhina AG, Staroverov DB, Belousov VV, Zhigalova NA, Prokhortchouk EB, Zaraisky AG, Martynova NY. Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status. Cell Rep. 2020;33(7):108396. doi:10.1016/j.celrep.2020.108396.

Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression

Authors:
Wu CS, Lu YF, Liu YH, Huang CJ, Hwang SL
Citation:
Dev Biol. 2020 Nov 13:S0012-1606(20)30293-1. doi: 10.1016/j.ydbio.2020.11.001. Online ahead of print
Epub:
Yes
Abstract:
Nodal signaling is essential for mesoderm and endoderm formation, as well as neural plate induction and establishment of left-...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160620302931
Delivery Method:
microinjection, Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Wu CS, Lu YF, Liu YH, Huang CJ, Hwang SL. Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression. Dev Biol. 2020 Nov 13:S0012-1606(20)30293-1. doi: 10.1016/j.ydbio.2020.11.001. Online ahead of print.

GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base

Authors:
Jang DG, Kwon KY, Kweon YC, Kim B-g, Myung K, Lee H-S, Park CY, Kwon T, Park TJ
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.13.381764
Epub:
Not Epub
Abstract:
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.13.381764v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Jang DG, Kwon KY, Kweon YC, Kim B-g, Myung K, Lee H-S, Park CY, Kwon T, Park TJ. GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.13.381764 .

Pcdh18a-positive tip cells instruct notochord formation in zebrafish

Authors:
Bosze B, Mattes B, Sinner C, Stricker K, Gourain V, Thumberger T, Tlili S, Weber S, Wittbrodt J, Saunders TE, Strähle U, Schug A, Scholpp S
Citation:
bioRxiv. 2018;[preprint] doi:10.1101/257717
Epub:
Not Epub
Abstract:
The notochord defines the axial structure of all vertebrates during development. Notogenesis is a result of major cell...
Link:
https://www.biorxiv.org/content/10.1101/257717v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bosze B, Mattes B, Sinner C, Stricker K, Gourain V, Thumberger T, Tlili S, Weber S, Wittbrodt J, Saunders TE, Strähle U, Schug A, Scholpp S. Pcdh18a-positive tip cells instruct notochord formation in zebrafish. bioRxiv. 2018;[preprint] doi:10.1101/257717.

RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis

Authors:
Farooq M, Lindbæk L, Krogh N, Doganli C, Keller C, Mönnich M, Gonçalves AB, Sakthivel S, Mang Y, Fatima A, Andersen VS, Hussain MS, Eiberg H, Hansen L, Kjaer KW, Gopalakrishnan J, Pedersen LB, Møllgård K, Nielsen H, Baig SM, Tommerup N, Christensen ST, Larsen LA
Citation:
Nat Commun. 2020;11:5816 doi:10.1038/s41467-020-19658-0
Epub:
Not Epub
Abstract:
Primary microcephaly (MCPH) is characterized by reduced brain size and intellectual disability. The exact pathophysiological...
Link:
https://www.nature.com/articles/s41467-020-19658-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Farooq M, Lindbæk L, Krogh N, Doganli C, Keller C, Mönnich M, Gonçalves AB, Sakthivel S, Mang Y, Fatima A, Andersen VS, Hussain MS, Eiberg H, Hansen L, Kjaer KW, Gopalakrishnan J, Pedersen LB, Møllgård K, Nielsen H, Baig SM, Tommerup N, Christensen ST, Larsen LA. RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis. Nat Commun. 2020;11:5816 doi:10.1038/s41467-020-19658-0.

Investigating the effect of DMD non-sequential splicing on exon skipping strategies

Authors:
Goossens R, Verwey N, Schnell F, Aartsma-Rus A
Citation:
Neuromuscul Disord. 2020;30(Suppl 1):S128-S129. P.281 doi:10.1016/j.nmd.2020.08.278
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy is one of the most common myopathies, with an incidence of 1:5000 in new-born boys. The root cause...
Link:
https://www.nmd-journal.com/article/S0960-8966(20)30475-2/fulltext
Organism or Cell Type:
cell culture: myocytes
Citation Extract:
Goossens R, Verwey N, Schnell F, Aartsma-Rus A. Investigating the effect of DMD non-sequential splicing on exon skipping strategies. Neuromuscul Disord. 2020;30(Suppl 1):S128-S129. P.281 doi:10.1016/j.nmd.2020.08.278.

Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.

Authors:
Cui J, Chen G, Wen D, Wang Y, Zhao Z, Wu C
Citation:
Front Cell Infect Microbiol. 2020 Oct 29;10:519503. doi: 10.3389/fcimb.2020.519503
Epub:
Not Epub
Abstract:
The ADP ribosylation factor (ARF) GTPase activation protein ASAP1 possesses multiple biological functions, including regulation...
Link:
https://www.frontiersin.org/articles/10.3389/fcimb.2020.519503/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cui J, Chen G, Wen D, Wang Y, Zhao Z, Wu C. Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.. Front Cell Infect Microbiol. 2020 Oct 29;10:519503. doi: 10.3389/fcimb.2020.519503.

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