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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis

Authors:
Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D
Citation:
Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9
Epub:
Not Epub
Abstract:
GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation and glycophosphatidylinositol anchor synthesis,...
Link:
https://www.nature.com/articles/s41594-021-00591-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D. Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9.

A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements

Authors:
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H
Citation:
Science. 2021;372(6543): doi:10.1126/science.abc7531
Epub:
Not Epub
Abstract:
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain...
Link:
https://science.sciencemag.org/content/372/6543/eabc7531.full
Delivery Method:
Endo-Porter
Organism or Cell Type:
Cell culture: HCC1806-LM2 , MDA-LM2
Citation Extract:
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H. A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements. Science. 2021;372(6543): doi:10.1126/science.abc7531.

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

Authors:
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI
Citation:
Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740
Epub:
Not Epub
Abstract:
Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that...
Link:
https://science.sciencemag.org/content/372/6543/716
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740.

Maternal and zygotic contributions to H3K4me1 chromatin marking during germ layer formation

Authors:
Paraiso KD, Blitz IL, Cho KWY
Citation:
Dev Biol. 2025 Feb;518:8-19. doi: 10.1016/j.ydbio.2024.11.006. Epub 2024 Nov 15. PMID: 39550025; PMCID: PMC11796633
Epub:
Not Epub
Abstract:
An early step in triploblastic embryo differentiation is the formation of the three germ layers. Maternal pioneer transcription...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160624002586
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Paraiso KD, Blitz IL, Cho KWY. Maternal and zygotic contributions to H3K4me1 chromatin marking during germ layer formation. Dev Biol. 2025 Feb;518:8-19. doi: 10.1016/j.ydbio.2024.11.006. Epub 2024 Nov 15. PMID: 39550025; PMCID: PMC11796633.

Sox8 remodels the cranial ectoderm to generate the ear

Authors:
Buzzi AL, Chen J, Thiery A, Delile J, Streit A
Citation:
Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2118938119. doi: 10.1073/pnas.2118938119. Epub 2022 Jul 8. PMID: 35867760; PMCID: PMC9282420
Epub:
Not Epub
Abstract:
The vertebrate inner ear arises from a pool of progenitors with the potential to contribute to all the sense organs and cranial...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9282420/
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Buzzi AL, Chen J, Thiery A, Delile J, Streit A. Sox8 remodels the cranial ectoderm to generate the ear. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2118938119. doi: 10.1073/pnas.2118938119. Epub 2022 Jul 8. PMID: 35867760; PMCID: PMC9282420.

Involvement of Huntingtin in Development and Ciliary Beating Regulation of Larvae of the Sea Urchin, Hemicentrotus pulcherrimus

Authors:
Katow H, Katow T, Yoshida H, Kiyomoto M
Citation:
Int J Mol Sci. 2021;22(10):5116. doi:10.3390/ijms22105116
Epub:
Not Epub
Abstract:
The multiple functions of the wild type Huntington’s disease protein of the sea urchin Hemicentrotus pulcherrimus (Hp-Htt) have...
Link:
https://www.mdpi.com/1422-0067/22/10/5116/htm
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Katow H, Katow T, Yoshida H, Kiyomoto M. Involvement of Huntingtin in Development and Ciliary Beating Regulation of Larvae of the Sea Urchin, Hemicentrotus pulcherrimus. Int J Mol Sci. 2021;22(10):5116. doi:10.3390/ijms22105116.

Knockdown of miR-26a in Zebrafish Leads to Impairment of the Anti-Inflammatory Function of TnP in the Control of Neutrophilia

Authors:
Falcao MAP, Walker COB, Disner GR, Batista-Filho J, Soares ABS, Balan-Lima L, Lima C, Lopes-Ferreira M
Citation:
Fish Shellfish Immunol. 2021;[Epub] doi:10.1016/j.fsi.2021.04.029
Epub:
Yes
Abstract:
Our recent data show the valuable potential of TnP for the development of a new and safe anti-inflammatory drug due to its...
Link:
https://www.sciencedirect.com/science/article/pii/S1050464821001194
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Falcao MAP, Walker COB, Disner GR, Batista-Filho J, Soares ABS, Balan-Lima L, Lima C, Lopes-Ferreira M. Knockdown of miR-26a in Zebrafish Leads to Impairment of the Anti-Inflammatory Function of TnP in the Control of Neutrophilia. Fish Shellfish Immunol. 2021;[Epub] doi:10.1016/j.fsi.2021.04.029.

Identification of Zebrafish Ortholog for Human Coagulation Factor IX and its Age-dependent Expression

Authors:
Iyer N, Al Qaryoute A, Kacham M, Jagadeeswaran P
Citation:
J Thromb Haemost. 2021 May 11. doi: 10.1111/jth.15365. Online ahead of print
Epub:
Yes
Abstract:
Background: Coagulation factor IX (FIX) is a serine protease zymogen involved in the intrinsic blood coagulation pathway, and...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/jth.15365
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Iyer N, Al Qaryoute A, Kacham M, Jagadeeswaran P. Identification of Zebrafish Ortholog for Human Coagulation Factor IX and its Age-dependent Expression. J Thromb Haemost. 2021 May 11. doi: 10.1111/jth.15365. Online ahead of print.

The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus

Authors:
Zhang F, Zhu X, Wang P, He Q, Huang H, Zheng T, Li Y, Jia H, Xu L, Zhao H, Colozza G, Tao Q, De Robertis EM, Ding Y
Citation:
Proc Nat Acad Sci USA. 2021;118(20):e2100342118. doi:10.1073/pnas.2100342118
Epub:
Not Epub
Abstract:
Fibroblast growth factor (FGF)/extracellular signal-regulated kinase (ERK) signaling plays a crucial role in anterior–posterior...
Link:
https://www.pnas.org/content/118/20/e2100342118
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Zhang F, Zhu X, Wang P, He Q, Huang H, Zheng T, Li Y, Jia H, Xu L, Zhao H, Colozza G, Tao Q, De Robertis EM, Ding Y. The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus. Proc Nat Acad Sci USA. 2021;118(20):e2100342118. doi:10.1073/pnas.2100342118.

RNA m6A methyltransferase Mettl3 regulates spatial neural patterning in Xenopus

Authors:
Kim H, Jang S
Citation:
Mol Cell Biol. 2021 May 10:MCB.00104-21. doi: 10.1128/MCB.00104-21. Online ahead of print
Epub:
Yes
Abstract:
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, and has a widespread impact on mRNA stability and...
Link:
https://mcb.asm.org/content/early/2021/05/04/MCB.00104-21
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kim H, Jang S. RNA m6A methyltransferase Mettl3 regulates spatial neural patterning in Xenopus. Mol Cell Biol. 2021 May 10:MCB.00104-21. doi: 10.1128/MCB.00104-21. Online ahead of print.

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