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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome

Authors:
Mann N, Mzoughi S, Schneider R, Kühl SJ, Schanze D, Klämbt V, Lovric S, Mao Y, Shi S, Tan W, Kühl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F
Citation:
J Am Soc Nephrol. 2021 Mar;32(3):580-596. doi: 10.1681/ASN.2020040490
Epub:
Not Epub
Abstract:
Background: Galloway-Mowat syndrome (GAMOS) is characterized by neurodevelopmental defects and a progressive nephropathy, which...
Link:
https://jasn.asnjournals.org/content/early/2021/02/15/ASN.2020040490
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Mann N, Mzoughi S, Schneider R, Kühl SJ, Schanze D, Klämbt V, Lovric S, Mao Y, Shi S, Tan W, Kühl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F. Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. J Am Soc Nephrol. 2021 Mar;32(3):580-596. doi: 10.1681/ASN.2020040490.

Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish

Authors:
Shen B, Wada S, Nishioka H, Nagata T, Kawano-Yamashita E, Koyanagi M, Terakita A
Citation:
Zoological Lett. 2021;7(1),1. doi:10.1186/s40851-021-00171-1
Epub:
Not Epub
Abstract:
In the pineal organ of zebrafish larvae, the bistable opsin parapinopsin alone generates color opponency between UV and visible...
Link:
https://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-021-00171-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen B, Wada S, Nishioka H, Nagata T, Kawano-Yamashita E, Koyanagi M, Terakita A. Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish. Zoological Lett. 2021;7(1),1. doi:10.1186/s40851-021-00171-1.

Highly sensitive screening of antisense sequences for different types of DMD mutations in patients' urine-derived cells

Authors:
Takizawa H, Takeshita E, Sato M, Shimizu-Motohashi Y, Ishiyama A, Mori-Yoshimura M, Takahashi Y, Komaki H, Aoki Y
Citation:
J Neurol Sci. 2021;[Epub ahead of print] doi:10.1016/j.jns.2021.117337
Epub:
Not Epub
Abstract:
Exon skipping using short antisense oligonucleotides (AONs) is a promising treatment for Duchenne muscular dystrophy (DMD)....
Link:
https://www.jns-journal.com/article/S0022-510X(21)00030-7/fulltext
Delivery Method:
Endo-Porter, electroporation
Organism or Cell Type:
cell culture: UDC-myotubes, rhabdomyosarcoma cells, human skeletal myoblasts
Citation Extract:
Takizawa H, Takeshita E, Sato M, Shimizu-Motohashi Y, Ishiyama A, Mori-Yoshimura M, Takahashi Y, Komaki H, Aoki Y. Highly sensitive screening of antisense sequences for different types of DMD mutations in patients' urine-derived cells. J Neurol Sci. 2021;[Epub ahead of print] doi:10.1016/j.jns.2021.117337.

ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders

Authors:
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN
Citation:
J Clin Invest. 2021 Feb 15;131(4):138634. doi: 10.1172/JCI138634
Epub:
Not Epub
Abstract:
Patients with neuromuscular disorders suffer from a lack of treatment options for skeletal muscle weakness and disease...
Link:
https://www.jci.org/articles/view/138634
Delivery Method:
injection
Organism or Cell Type:
mice (mdx)
Citation Extract:
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN. ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders. J Clin Invest. 2021 Feb 15;131(4):138634. doi: 10.1172/JCI138634.

Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy

Authors:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH
Citation:
Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30408-X
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: iPSC
Citation Extract:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH. Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy. Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5.

Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset

Authors:
Mournetas V, Massouridès E, Dupont JB, Kornobis E, Polvèche H, Jarrige M, Dorval ARL, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C
Citation:
J Cachexia Sarcopenia Muscle. 2021 Feb 14. doi: 10.1002/jcsm.12665. Online ahead of print
Epub:
Yes
Abstract:
Background: Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12665
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: hiPSC, DMD Delta52 hESC‐derived
Citation Extract:
Mournetas V, Massouridès E, Dupont JB, Kornobis E, Polvèche H, Jarrige M, Dorval ARL, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C. Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset. J Cachexia Sarcopenia Muscle. 2021 Feb 14. doi: 10.1002/jcsm.12665. Online ahead of print.

Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development

Authors:
Dong Z, Chen X, Li Y, Zhuo R, Lai X, Liu M
Citation:
Front Cell Dev Biol. 2021 Jan 18;8:593234. doi: 10.3389/fcell.2020.593234. eCollection 2020
Epub:
Not Epub
Abstract:
Previously, fidgetin (fign) and its family members fidgetin-like 1 (fignl1) and fidgetin-like 2 (fignl2) were found to be...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.593234/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dong Z, Chen X, Li Y, Zhuo R, Lai X, Liu M. Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development. Front Cell Dev Biol. 2021 Jan 18;8:593234. doi: 10.3389/fcell.2020.593234. eCollection 2020.

Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish

Authors:
Li X, Ji G, Zhou J, Du J, Li X, Shi W, Hu Y, Zhou W, Hao A
Citation:
Front Cell Dev Biol. 2021 Jan 26;8:581636. doi: 10.3389/fcell.2020.581636. eCollection 2020
Epub:
Not Epub
Abstract:
The neural induction constitutes the initial step in the generation of the neural tube. Pcgf1, as one of six Pcgf paralogs, is...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.581636/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Ji G, Zhou J, Du J, Li X, Shi W, Hu Y, Zhou W, Hao A. Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Front Cell Dev Biol. 2021 Jan 26;8:581636. doi: 10.3389/fcell.2020.581636. eCollection 2020.

Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?

Authors:
Hughes MC, Perry SF
Citation:
J Comp Physiol B. 2021 Feb 12. doi: 10.1007/s00360-020-01331-z. Online ahead of print
Epub:
Yes
Abstract:
Oxygen uptake (ṀO2) in larval zebrafish prior to maturation of the gill relies on cutaneous O2 transfer. Under normoxic...
Link:
https://link.springer.com/article/10.1007%2Fs00360-020-01331-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hughes MC, Perry SF. Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?. J Comp Physiol B. 2021 Feb 12. doi: 10.1007/s00360-020-01331-z. Online ahead of print.

Methods of In Vivo Gene-Specific Knockdown Using Morpholino and Vivo-Morpholino Oligonucleotides

Authors:
Ivanova AS, Korotkova DD, Martynova NY, Averyanova OV, Zaraisky AG, Tereshina MB
Citation:
Russ J Bioorg Chem. 2018;44:358–361. doi:10.1134/S106816201803007X
Epub:
Not Epub
Abstract:
The functioning of the small GTPase gene, Ras-dva1, has been studied during regeneration processes of the tadpole tails of the...
Link:
https://link.springer.com/article/10.1134/S106816201803007X
Delivery Method:
microinjection, Vivo-Morpholino injection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ivanova AS, Korotkova DD, Martynova NY, Averyanova OV, Zaraisky AG, Tereshina MB. Methods of In Vivo Gene-Specific Knockdown Using Morpholino and Vivo-Morpholino Oligonucleotides. Russ J Bioorg Chem. 2018;44:358–361. doi:10.1134/S106816201803007X.

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