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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish
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Citation:
Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z Epub:
Not Epub Abstract:
The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z. |
Rab11fip5 regulates telencephalon development via ephrinB1 recycling
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Citation:
Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print Epub:
Yes Abstract:
Rab11 family-interacting protein 5 (Rab11fip5) is an adaptor protein that binds to the small GTPase Rab11, which has an... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO. Rab11fip5 regulates telencephalon development via ephrinB1 recycling. Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print. |
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish
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Citation:
Theranostics. 2021 Jan 1;11(6):2788-2805. doi: 10.7150/thno.53330. eCollection 2021 Epub:
Not Epub Abstract:
Lipin 1 is an intracellular protein acting as a phosphatidic acid phosphohydrolase enzyme controlling lipid metabolism. Human... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lu S, Lyu Z, Wang Z, Kou Y, Liu C, Li S, Hu M, Zhu H, Wang W, Zhang C, Kuan YS, Liu YW, Chen J, Tian J. Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 2021 Jan 1;11(6):2788-2805. doi: 10.7150/thno.53330. eCollection 2021. |
Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish
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Citation:
J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print Epub:
Yes Abstract:
Aims/introduction: β-cell dysfunction is a hallmark of type 2 diabetes. In a previous pilot study, we identified an association... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW. Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print. |
Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice
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Citation:
Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print Epub:
Yes Abstract:
Genetic programs underlying preimplantation development and early lineage segregation are highly conserved across mammals. It... Organism or Cell Type:
cynomolgus monkey embryo Citation Extract: Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G. Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice. Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print. |
Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition
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Citation:
Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J Epub:
Not Epub Abstract:
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne... Citation Extract: Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ. Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition. Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J. |
Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions
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Citation:
Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011 Epub:
Not Epub Abstract:
The posterior lateral line system (pLLS) of aquatic animals comprises small clustered mechanosensory organs along the side of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J. Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011 . |
Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance
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Citation:
Sci Rep. 2021;11:1604. doi:10.1038/s41598-021-81222-7 Epub:
Not Epub Abstract:
Myostatin is a negative regulator of muscle mass and its inhibition represents a promising strategy for the treatment of muscle... Delivery Method:
intramuscular i.m. or intravenous i.v. injection Organism or Cell Type:
mice C57/Bl6 Citation Extract: Eilers W, Cleasby M, Foster K. Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance. Sci Rep. 2021;11:1604. doi:10.1038/s41598-021-81222-7. |
Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model
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Citation:
Sci Rep. 2021;11:1372. doi:10.1038/s41598-020-80621-6 Epub:
Not Epub Abstract:
It has been well known that tumor progression is dependent on secreted factors not only from tumor cells but also from other... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Helal M, Yan C, Gong Z. Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Sci Rep. 2021;11:1372. doi:10.1038/s41598-020-80621-6. |
Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo
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Citation:
mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20 Epub:
Not Epub Abstract:
Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered... Delivery Method:
peptide-linked Organism or Cell Type:
Pseudomonas aeruginosa as biofilm or murine pneumonial infection Citation Extract: Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo. mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20. |