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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12152 scientific papers returned from the database with the search filters currently being used below.

Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells

Authors:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E
Citation:
J Virol. 2021 Sep 27;95(20):e0090621. doi: 10.1128/JVI.00906-21. Epub 2021 Jul 28. PMID: 34319155; PMCID: PMC8475512
Epub:
Not Epub
Abstract:
Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8475512/
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human and mouse airway cells
Citation Extract:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E. Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells. J Virol. 2021 Sep 27;95(20):e0090621. doi: 10.1128/JVI.00906-21. Epub 2021 Jul 28. PMID: 34319155; PMCID: PMC8475512.

Role of the cardiovascular system in ammonia excretion in early life stages of zebrafish (Danio rerio)

Authors:
Wang Y, Pasparakis C, Grosell M
Citation:
Am J Physiol Regul Integr Comp Physiol. 2021 Jul 28. doi: 10.1152/ajpregu.00284.2020. Online ahead of print
Epub:
Yes
Abstract:
The purpose of this study was to investigate if the cardiovascular system is important for ammonia excretion in the early life...
Link:
https://journals.physiology.org/doi/abs/10.1152/ajpregu.00284.2020
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang Y, Pasparakis C, Grosell M. Role of the cardiovascular system in ammonia excretion in early life stages of zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2021 Jul 28. doi: 10.1152/ajpregu.00284.2020. Online ahead of print.

Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target

Authors:
Raman R, Fallatah W, Al Qaryoute A, Dhinoja S, Jagadeeswaran P
Citation:
Sci Rep. 2021 Jul 27;11(1):15238. doi: 10.1038/s41598-021-94715-2
Epub:
Not Epub
Abstract:
Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor VIIa and Xa in the coagulation cascade...
Link:
https://www.nature.com/articles/s41598-021-94715-2
Delivery Method:
Vivo-Morpholino piggyback hybrid
Organism or Cell Type:
zebrafish
Citation Extract:
Raman R, Fallatah W, Al Qaryoute A, Dhinoja S, Jagadeeswaran P. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci Rep. 2021 Jul 27;11(1):15238. doi: 10.1038/s41598-021-94715-2.

A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

Authors:
Cacialli P, Mahony CB, Petzold T, Bordignon P, Rougemont A-L, Bertrand JY
Citation:
Nat Commun. 2021;12(1):4484. doi:10.1038/s41467-021-24831-0
Epub:
Not Epub
Abstract:
Reactive oxygen species (ROS) represent a by-product of metabolism and their excess is toxic for hematopoietic stem and...
Link:
https://www.nature.com/articles/s41467-021-24831-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cacialli P, Mahony CB, Petzold T, Bordignon P, Rougemont A-L, Bertrand JY. A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress. Nat Commun. 2021;12(1):4484. doi:10.1038/s41467-021-24831-0.

An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier

Authors:
Chang WW, Matt A-S, Schewe M, Musinszki M, Grüssel S, Brandenburg J, Garfield D, Bleich M, Baukrowitz T, Hu MY
Citation:
Proc Nat Acad Sci USA. 2021;118(30):e2101378118. doi:10.1073/pnas.2101378118
Epub:
Not Epub
Abstract:
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and...
Link:
https://www.pnas.org/content/118/30/e2101378118.full
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Chang WW, Matt A-S, Schewe M, Musinszki M, Grüssel S, Brandenburg J, Garfield D, Bleich M, Baukrowitz T, Hu MY. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier. Proc Nat Acad Sci USA. 2021;118(30):e2101378118. doi:10.1073/pnas.2101378118.

MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes

Authors:
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F
Citation:
Nat Commun. 2021;12:4427. doi:10.1038/s41467-021-24724-2
Epub:
Not Epub
Abstract:
The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane...
Link:
https://www.nature.com/articles/s41467-021-24724-2
Delivery Method:
intranasal Vivo-Morpholino
Organism or Cell Type:
C57Bl/6 mice
Citation Extract:
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F. MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Nat Commun. 2021;12:4427. doi:10.1038/s41467-021-24724-2.

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Authors:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL
Citation:
Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4
Epub:
Not Epub
Abstract:
Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine...
Link:
https://www.nature.com/articles/s41467-021-24598-4
Delivery Method:
cell bathing
Organism or Cell Type:
cell culture: Vero-E6 & SARS-CoV-2
Citation Extract:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL. Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers. Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4.

Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

Authors:
Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J
Citation:
Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281
Epub:
Not Epub
Abstract:
Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101281
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281.

Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae

Authors:
Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP
Citation:
J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print
Epub:
Not Epub
Abstract:
Freshwater fish live in environments where pH levels fluctuate more than those in seawater. During acidic stress, the acid-base...
Link:
https://link.springer.com/article/10.1007%2Fs00360-021-01390-w
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP. Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae. J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print.

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

Authors:
Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B
Citation:
Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006
Epub:
Yes
Abstract:
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing...
Link:
https://www.sciencedirect.com/science/article/pii/S1672022921001467
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B. SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006.

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