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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Clathrin Heavy Chain 1 Plays Essential Roles During Oocyte Meiotic Spindle Formation and Early Embryonic Development in Sheep

Authors:
Han Z, Hao X, Zhou CJ, Wang J, Wen X, Wang XY, Zhang DJ, Liang CG
Citation:
Front Cell Dev Biol. 2021 Feb 25;9:609311. doi:10.3389/fcell.2021.609311. eCollection 2021
Epub:
Not Epub
Abstract:
As a major protein of the polyhedral coat of coated pits and vesicles, clathrin molecules have been shown to play a...
Delivery Method:
microinjection
Organism or Cell Type:
Ovis aries (sheep oocytes)
Citation Extract:
Han Z, Hao X, Zhou CJ, Wang J, Wen X, Wang XY, Zhang DJ, Liang CG. Clathrin Heavy Chain 1 Plays Essential Roles During Oocyte Meiotic Spindle Formation and Early Embryonic Development in Sheep. Front Cell Dev Biol. 2021 Feb 25;9:609311. doi:10.3389/fcell.2021.609311. eCollection 2021.

kinesin recruitment by adapter SKIP on melanosomes is dynamically controlled by LC3B phosphorylation

Authors:
Subramaniam Y, Murthy D, Raja DA, Ramkumar A, Sivasubbu S, McEwan DG, Gokhale RS, Natarajan VT
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434917
Epub:
Not Epub
Abstract:
Anterograde melanosome transport is essential for adaptive skin tanning response. However, the molecular components involved,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Subramaniam Y, Murthy D, Raja DA, Ramkumar A, Sivasubbu S, McEwan DG, Gokhale RS, Natarajan VT. kinesin recruitment by adapter SKIP on melanosomes is dynamically controlled by LC3B phosphorylation. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434917.

Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling

Authors:
Xiao Y, Hoodless LJ, Petrucco L, Portugues R, Czopka T
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434829
Epub:
Not Epub
Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xiao Y, Hoodless LJ, Petrucco L, Portugues R, Czopka T. Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434829.

miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury

Authors:
Li X, Gao Y, Tian F, Du R, Yuan Y, Li P, Liu F, Wang C
Citation:
Exp Biol Med (Maywood). 2021 Mar 9:1535370221997071. doi: 10.1177/1535370221997071. Online ahead of print
Epub:
Not Epub
Abstract:
This study aims to examine whether miR-31 promotes endogenous NSC proliferation and be used for spinal cord injury management....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Gao Y, Tian F, Du R, Yuan Y, Li P, Liu F, Wang C. miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury. Exp Biol Med (Maywood). 2021 Mar 9:1535370221997071. doi: 10.1177/1535370221997071. Online ahead of print.

Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury

Authors:
Goldman D, Sahu A, Devi S, Jui J
Citation:
bioRxiv. 2021;[preprint] doi:/10.1101/2021.03.11.435053
Epub:
Not Epub
Abstract:
Unlike mammals, zebrafish can regenerate a damaged retina. Key to this regenerative response are Müller glia (MG) that divide...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Goldman D, Sahu A, Devi S, Jui J. Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. bioRxiv. 2021;[preprint] doi:/10.1101/2021.03.11.435053.

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson–Gilford progeria syndrome

Authors:
Puttaraju M, Jackson M, Klein S, Shilo A, Bennett CF, Gordon L, Rigo F, Misteli T
Citation:
Nat Med. 2021;[Epub ahead of print] doi:10.1038/s41591-021-01262-4
Epub:
Yes
Abstract:
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, invariably fatal childhood premature aging disorder caused by a pre-...
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Puttaraju M, Jackson M, Klein S, Shilo A, Bennett CF, Gordon L, Rigo F, Misteli T. Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson–Gilford progeria syndrome. Nat Med. 2021;[Epub ahead of print] doi:10.1038/s41591-021-01262-4.

A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome

Authors:
Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS
Citation:
Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11.
Epub:
Not Epub
Abstract:
Hutchinson–Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder characterized by premature death from...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human progeric fibroblasts, mice
Citation Extract:
Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11..

Lamb1a regulates atrial growth by limiting excessive, contractility-dependent second heart field addition during zebrafish heart development

Authors:
Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F, Noel ES
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.10.434727
Epub:
Not Epub
Abstract:
During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure. This...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F, Noel ES. Lamb1a regulates atrial growth by limiting excessive, contractility-dependent second heart field addition during zebrafish heart development. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.10.434727 .

Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients

Authors:
Signorelli M, Ebrahimpoor M, Veth O, Hettne K, Verwey N, García‐Rodríguez R, Tanganyika‐deWinter CL, Lopez Hernandez LB, Cedillo RE, Díaz BG, Magnusson OT, Mei H, Tsonaka R, Aartsma‐Rus A, Spitali P
Citation:
EMBO Mol Med. 2021;e13328. doi:10.15252/emmm.202013328
Epub:
Not Epub
Abstract:
DMD is a rare disorder characterized by progressive muscle degeneration and premature death. Therapy development is delayed by...
Delivery Method:
i.v. injection
Organism or Cell Type:
mice mdx
Citation Extract:
Signorelli M, Ebrahimpoor M, Veth O, Hettne K, Verwey N, García‐Rodríguez R, Tanganyika‐deWinter CL, Lopez Hernandez LB, Cedillo RE, Díaz BG, Magnusson OT, Mei H, Tsonaka R, Aartsma‐Rus A, Spitali P. Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients. EMBO Mol Med. 2021;e13328. doi:10.15252/emmm.202013328.

Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families

Authors:
Madhangi M, Dutta D, Show S, Bhat VK, Rather MI, Tiwari A, Singh N, Duvvari MR, Murthy GJ, Kumar A, Nongthomba U
Citation:
Hum Mol Genet. 2021;ddab061. doi:10.1093/hmg/ddab061
Epub:
Not Epub
Abstract:
Isolated Microspherophakia (MSP) is an autosomal recessive disorder characterised by a smaller than normal spherical lens. Till...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Madhangi M, Dutta D, Show S, Bhat VK, Rather MI, Tiwari A, Singh N, Duvvari MR, Murthy GJ, Kumar A, Nongthomba U. Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families. Hum Mol Genet. 2021;ddab061. doi:10.1093/hmg/ddab061.

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