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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds

Authors:
Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K
Citation:
Development. 2021;148:dev1905008 doi:10.1242/dev.195008
Epub:
Yes
Abstract:
Pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs)...
Link:
https://dev.biologists.org/content/148/2/dev195008
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K. Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. Development. 2021;148:dev1905008 doi:10.1242/dev.195008.

Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing

Authors:
Presnell JS, Browne WE
Citation:
bioRxiv. 2020;[preprint] doi: https://doi.org/10.1101/527002
Epub:
Not Epub
Abstract:
The Krüppel-like factor (Klf) gene family encodes for transcription factors that play an important role in the regulation of...
Link:
https://www.biorxiv.org/content/10.1101/527002v3
Delivery Method:
microinjection
Organism or Cell Type:
Mnemiopsis leidyi (ctenophore)
Citation Extract:
Presnell JS, Browne WE. Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing. bioRxiv. 2020;[preprint] doi: https://doi.org/10.1101/527002 .

Somite surface tension buffers imprecise segment lengths to ensure left-right symmetry

Authors:
Naganathan SR, Popović M, Oates AC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251645
Epub:
Not Epub
Abstract:
The body axis of vertebrate embryos is periodically segmented into bilaterally symmetric pairs of somites. The anteroposterior...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.14.251645v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Naganathan SR, Popović M, Oates AC. Somite surface tension buffers imprecise segment lengths to ensure left-right symmetry. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251645 .

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

Authors:
Gentile A, Bensimon-Brito A, Priya R, Maischein H-M, Piesker J, Günther S, Gunawan F, Stainier DYR
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.15.422833
Epub:
Not Epub
Abstract:
The zinc finger transcription factor Snai1 is a well-known regulator of epithelial-to-mesenchymal transition (EMT)1, 2; it is...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.15.422833v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gentile A, Bensimon-Brito A, Priya R, Maischein H-M, Piesker J, Günther S, Gunawan F, Stainier DYR. The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.15.422833 .

Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience

Authors:
Willsey HR, Exner CRT, Xu Y, Everitt A, Sun N, Wang B, Dea J, Schmunk G, Zaltsman Y, Teerikorpi N, Kim A, Anderson AS, Shin D, Seyler M, Nowakowski TJ, Harland RM, Willsey AJ, State MW
Citation:
Neuron. 2021;[Epub ahead of print] doi:10.1016/j.neuron.2021.01.002
Epub:
Yes
Abstract:
Gene Ontology analyses of autism spectrum disorders (ASD) risk genes have repeatedly highlighted synaptic function and...
Link:
https://www.cell.com/neuron/fulltext/S0896-6273(21)00002-7
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Willsey HR, Exner CRT, Xu Y, Everitt A, Sun N, Wang B, Dea J, Schmunk G, Zaltsman Y, Teerikorpi N, Kim A, Anderson AS, Shin D, Seyler M, Nowakowski TJ, Harland RM, Willsey AJ, State MW. Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience. Neuron. 2021;[Epub ahead of print] doi:10.1016/j.neuron.2021.01.002.

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Authors:
Prentzell MT, Rehbein U, Sandoval MC, De Meulemeester A-S, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Pittol JMR, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K
Citation:
Cell. 2021;184:[Epub ahead of print] doi:10.1016/j.cell.2020.12.024
Epub:
Yes
Abstract:
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components...
Link:
https://www.cell.com/cell/fulltext/S0092-8674(20)31694-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prentzell MT, Rehbein U, Sandoval MC, De Meulemeester A-S, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Pittol JMR, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021;184:[Epub ahead of print] doi:10.1016/j.cell.2020.12.024.

Anterior lateral plate mesoderm gives rise to multiple tissues and requires tbx5a function in left-right asymmetry, migration dynamics, and cell specification of late-addition cardiac cells

Authors:
Mao LMF, Boyle Anderson EAT, Ho RK
Citation:
Dev Biol. 2021;472:52-66. doi:10.1016/j.ydbio.2021.01.007
Epub:
Not Epub
Abstract:
In this study, we elucidate a single cell resolution fate map in the zebrafish in a sub-section of the anterior Lateral Plate...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160621000191
Organism or Cell Type:
zebrafish
Citation Extract:
Mao LMF, Boyle Anderson EAT, Ho RK. Anterior lateral plate mesoderm gives rise to multiple tissues and requires tbx5a function in left-right asymmetry, migration dynamics, and cell specification of late-addition cardiac cells. Dev Biol. 2021;472:52-66. doi:10.1016/j.ydbio.2021.01.007.

Coup-TF: A maternal factor essential for differentiation along the embryonic axes in the sea urchin Paracentrotus lividus

Authors:
Tsironis I, Paganos P, Gouvi G, Tsimpos P, Stamopoulou A, Arnone MI, Flytzanis CN
Citation:
Dev Biol. 2021 Jan 20:S0012-1606(20)30322-5. doi:10.1016/j.ydbio.2020.12.012. Online ahead of print
Epub:
Yes
Abstract:
Coup-TF, a member of the nuclear receptor super-family, is present in the pool of maternal mRNAs and proteins in the sea urchin...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620303225
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Tsironis I, Paganos P, Gouvi G, Tsimpos P, Stamopoulou A, Arnone MI, Flytzanis CN. Coup-TF: A maternal factor essential for differentiation along the embryonic axes in the sea urchin Paracentrotus lividus. Dev Biol. 2021 Jan 20:S0012-1606(20)30322-5. doi:10.1016/j.ydbio.2020.12.012. Online ahead of print.

Insulin-Like Growth Factor-1 Enhances Motoneuron Survival and Inhibits Neuroinflammation After Spinal Cord Transection in Zebrafish

Authors:
Zhao L, Zhang B, Huang S, Zhou Z, Jia X, Qiao C, Wang F, Sun M, Shi Y, Yao L, Cui C, Shen Y
Citation:
Cell Mol Neurobiol. 2021 Jan 22. doi:10.1007/s10571-020-01022-x. Online ahead of print
Epub:
Not Epub
Abstract:
Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor produced locally in the central nervous system which can promote...
Link:
https://link.springer.com/article/10.1007%2Fs10571-020-01022-x
Delivery Method:
lesion site
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao L, Zhang B, Huang S, Zhou Z, Jia X, Qiao C, Wang F, Sun M, Shi Y, Yao L, Cui C, Shen Y. Insulin-Like Growth Factor-1 Enhances Motoneuron Survival and Inhibits Neuroinflammation After Spinal Cord Transection in Zebrafish. Cell Mol Neurobiol. 2021 Jan 22. doi:10.1007/s10571-020-01022-x. Online ahead of print.

Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation

Authors:
Ma J, Scott CA, Ho YN, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W, Tergaonkar V, Partridge LJ, Roy S, Amaya E, Carney TJ
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.01.21.427549
Epub:
Not Epub
Abstract:
Tissues respond to damage by increasing inflammation and epithelial cell motility. How damage detection and responses are...
Link:
https://www.biorxiv.org/content/10.1101/2021.01.21.427549v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma J, Scott CA, Ho YN, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W, Tergaonkar V, Partridge LJ, Roy S, Amaya E, Carney TJ. Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation. bioRxiv. 2021;[preprint] doi:10.1101/2021.01.21.427549.

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