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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Mutation in epsilon-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice

Authors:
Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y
Citation:
Neurosci Bull. 2020 Dec 23. doi: 10.1007/s12264-020-00612-5. Online ahead of print
Epub:
Not Epub
Abstract:
Myoclonus dystonia syndrome (MDS) is an inherited movement disorder, and most MDS-related mutations have so far been found in...
Link:
https://link.springer.com/article/10.1007/s12264-020-00612-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in epsilon-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice. Neurosci Bull. 2020 Dec 23. doi: 10.1007/s12264-020-00612-5. Online ahead of print.

Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells

Authors:
O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1
Epub:
Not Epub
Abstract:
Background: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the bHLH/PAS (basic...
Link:
https://www.researchsquare.com/article/rs-131951/v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hepa 1
Citation Extract:
O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK. Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1.

Transcriptome Profile of the Sinoatrial Ring Reveals Conserved and Novel Genetic Programs of the Zebrafish Pacemaker

Authors:
Minhas R, Loeffler-Wirth H, Siddiqui Y, Obrebski T, Vhashist S, Nahia KA, Paterek A, Brzozowska A, Bugajski L, Piwocka K, Korzh V, Binder H, Winata CL
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-130687/v1
Epub:
Not Epub
Abstract:
Background: Sinoatrial Node (SAN) is part of the cardiac conduction system, which controls the rhythmic contraction of the...
Link:
https://www.researchsquare.com/article/rs-130687/v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Minhas R, Loeffler-Wirth H, Siddiqui Y, Obrebski T, Vhashist S, Nahia KA, Paterek A, Brzozowska A, Bugajski L, Piwocka K, Korzh V, Binder H, Winata CL. Transcriptome Profile of the Sinoatrial Ring Reveals Conserved and Novel Genetic Programs of the Zebrafish Pacemaker. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-130687/v1.

Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis

Authors:
Shi Y, Liu Z, Zhang Q, Vallee I, Mo Z, Kishi S, Yang X-L
Citation:
PLoS Biol. 2020;18(12):e3000991. doi:10.1371/journal.pbio.3000991
Epub:
Not Epub
Abstract:
Hypoxia-induced angiogenesis maintains tissue oxygen supply and protects against ischemia but also enhances tumor progression...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000991
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi Y, Liu Z, Zhang Q, Vallee I, Mo Z, Kishi S, Yang X-L. Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis. PLoS Biol. 2020;18(12):e3000991. doi:10.1371/journal.pbio.3000991.

osr1 maintains renal progenitors and regulates podocyte development by promoting wnt2ba through antagonism of hand2

Authors:
Drummond BE, Chambers BE, Wesselman HM, Ulrich MN, Gerlach GF, Kroeger PT, Leshchiner I, Goessling W, Wingert RA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.21.423845
Epub:
Not Epub
Abstract:
Knowledge about the genetic pathways that control renal cell lineage development is essential to better understand the basis of...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.21.423845v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Drummond BE, Chambers BE, Wesselman HM, Ulrich MN, Gerlach GF, Kroeger PT, Leshchiner I, Goessling W, Wingert RA. osr1 maintains renal progenitors and regulates podocyte development by promoting wnt2ba through antagonism of hand2. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.21.423845 .

Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny

Authors:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT
Citation:
iScience. 2020;23(12):101805 doi:10.1016/j.isci.2020.101805
Epub:
Not Epub
Abstract:
The transcription factor NRL (neural retina leucine zipper) has been canonized as the master regulator of photoreceptor cell...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(20)31002-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT. Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny. iScience. 2020;23(12):101805 doi:10.1016/j.isci.2020.101805.

Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

Authors:
Lopez-Cuevas P, Deane L, Yang Y, Hammond CL, Kague E
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.12.18.423470
Epub:
Not Epub
Abstract:
Notochordal cells play a pivotal role in vertebral column patterning, contributing to the formation of the inner architecture...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.18.423470v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lopez-Cuevas P, Deane L, Yang Y, Hammond CL, Kague E. Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis. bioRxiv. 2020;[preprint] doi:10.1101/2020.12.18.423470 .

Post-transcriptional tuning of FGF signaling mediates neural crest induction

Authors:
Copeland J, Simoes-Costa M
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2009997117
Epub:
Not Epub
Abstract:
Ectodermal patterning is required for the establishment of multiple components of the vertebrate body plan. Previous studies...
Link:
https://www.pnas.org/content/early/2020/12/18/2009997117
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Copeland J, Simoes-Costa M. Post-transcriptional tuning of FGF signaling mediates neural crest induction. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2009997117.

The Genome-Wide Impact of Nipblb Loss-of-Function on Zebrafish Gene Expression

Authors:
Spreafico M, Mangano E, Mazzola M, Consolandi C, Bordoni R, Battaglia C, Bicciato S, Marozzi A, Pistocchi A
Citation:
Int J Mol Sci. 2020 Dec 19;21(24):E9719. doi: 10.3390/ijms21249719
Epub:
Not Epub
Abstract:
Transcriptional changes normally occur during development but also underlie differences between healthy and pathological...
Link:
https://www.mdpi.com/1422-0067/21/24/9719
Organism or Cell Type:
zebrafish
Citation Extract:
Spreafico M, Mangano E, Mazzola M, Consolandi C, Bordoni R, Battaglia C, Bicciato S, Marozzi A, Pistocchi A. The Genome-Wide Impact of Nipblb Loss-of-Function on Zebrafish Gene Expression. Int J Mol Sci. 2020 Dec 19;21(24):E9719. doi: 10.3390/ijms21249719.

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice

Authors:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H
Citation:
EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in Duchenne muscular dystrophy (DMD), a...
Link:
https://www.embopress.org/doi/full/10.15252/emmm.202012993
Delivery Method:
unlinked MOTS‐c peptide
Organism or Cell Type:
mouse mdx
Citation Extract:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H. MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice. EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993.

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