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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Co-option of the piRNA pathway to regulate neural crest specification

Authors:
Galton R, Fejes-Toth K, Bronner ME
Citation:
Sci Adv. 2022 Aug 12;8(32):eabn1441. doi: 10.1126/sciadv.abn1441. Epub 2022 Aug 10
Epub:
Not Epub
Abstract:
Across Metazoa, Piwi proteins play a critical role in protecting the germline genome through piRNA-mediated repression of...
Link:
https://www.science.org/doi/10.1126/sciadv.abn1441
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Galton R, Fejes-Toth K, Bronner ME. Co-option of the piRNA pathway to regulate neural crest specification. Sci Adv. 2022 Aug 12;8(32):eabn1441. doi: 10.1126/sciadv.abn1441. Epub 2022 Aug 10.

Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis

Authors:
Chaytow H, Carroll E, Gordon D, Huang YT, van der Hoorn D, Smith HL, Becker T, Becker CG, Faller KME, Talbot K, Gillingwater TH
Citation:
EBioMedicine. 2022 Aug 2:104202. doi: 10.1016/j.ebiom.2022.104202. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with heterogeneous aetiology and a...
Link:
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00384-X/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chaytow H, Carroll E, Gordon D, Huang YT, van der Hoorn D, Smith HL, Becker T, Becker CG, Faller KME, Talbot K, Gillingwater TH. Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis. EBioMedicine. 2022 Aug 2:104202. doi: 10.1016/j.ebiom.2022.104202. Online ahead of print.

Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates

Authors:
Cacialli P, Mailhe MP, Wagner I, Merkler D, Golub R, Bertrand JY
Citation:
EMBO J. 2022 Aug 4:e108536. doi: 10.15252/embj.2021108536. Online ahead of print
Epub:
Not Epub
Abstract:
During development, hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium and will expand in a transient...
Link:
https://www.embopress.org/doi/full/10.15252/embj.2021108536
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cacialli P, Mailhe MP, Wagner I, Merkler D, Golub R, Bertrand JY. Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. EMBO J. 2022 Aug 4:e108536. doi: 10.15252/embj.2021108536. Online ahead of print.

A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype

Authors:
Quelle-Regaldie A, Folgueira M, Yáñez J, Sobrido-Cameán D, Alba-González A, Barreiro-Iglesias A, Sobrido M-J, Sánchez L
Citation:
Biomedicines. 2022;10(8):1814. doi:10.3390/biomedicines10081814
Epub:
Not Epub
Abstract:
NOP56 belongs to a C/D box small nucleolar ribonucleoprotein complex that is in charge of cleavage and modification of...
Link:
https://www.mdpi.com/2227-9059/10/8/1814
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Quelle-Regaldie A, Folgueira M, Yáñez J, Sobrido-Cameán D, Alba-González A, Barreiro-Iglesias A, Sobrido M-J, Sánchez L. A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype. Biomedicines. 2022;10(8):1814. doi:10.3390/biomedicines10081814.

Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly

Authors:
Saha K, Ghosh G
Citation:
Nucleic Acids Res. 2022 Aug 12;50(14):8262-8278. doi: 10.1093/nar/gkac636
Epub:
Not Epub
Abstract:
We recently reported that serine-arginine-rich (SR) protein-mediated pre-mRNA structural remodeling generates a pre-mRNA 3D...
Link:
https://academic.oup.com/nar/article/50/14/8262/6649375
Delivery Method:
transfection
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Saha K, Ghosh G. Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly. Nucleic Acids Res. 2022 Aug 12;50(14):8262-8278. doi: 10.1093/nar/gkac636.

MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia

Authors:
Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, Grozeva D, Carss K, Smith M, Pall H, Lunt P, De Gressi S, Kamsteeg EJ, Haack TB, Carr L, Guerreiro R, Bras J, Maher ER, Scott RH, Vandenberg RJ, Raymond FL, Chong WK, Sudhakar S, Mankad K, Reith ME, Campeau PM, Harvey RJ, Kurian MA
Citation:
Mov Disord. 2022 Jul 25. doi: 10.1002/mds.29147. Online ahead of print
Epub:
Yes
Abstract:
Background: Despite advances in next generation sequencing technologies, the identification of variants of uncertain...
Link:
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29147
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, Grozeva D, Carss K, Smith M, Pall H, Lunt P, De Gressi S, Kamsteeg EJ, Haack TB, Carr L, Guerreiro R, Bras J, Maher ER, Scott RH, Vandenberg RJ, Raymond FL, Chong WK, Sudhakar S, Mankad K, Reith ME, Campeau PM, Harvey RJ, Kurian MA. MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Mov Disord. 2022 Jul 25. doi: 10.1002/mds.29147. Online ahead of print.

The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity

Authors:
Paradis M, Kucharowski N, Edwards Faret G, Palacios SJM, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow MH
Citation:
Sci Adv. 2022;8(29)eabo0155 doi:10.1126/sciadv.abo01
Epub:
Not Epub
Abstract:
Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and...
Link:
https://www.science.org/doi/10.1126/sciadv.abo0155
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Paradis M, Kucharowski N, Edwards Faret G, Palacios SJM, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow MH. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Sci Adv. 2022;8(29)eabo0155 doi:10.1126/sciadv.abo01.

Plasticity in astrocyte subpopulations regulates heroin relapse

Authors:
Kruyer A, Angelis A, Garcia-Keller C, Li H, Kalivas PW
Citation:
Sci Adv. 2022 Aug 12;8(32):eabo7044. doi: 10.1126/sciadv.abo7044. Epub 2022 Aug 10
Epub:
Not Epub
Abstract:
Opioid use disorder (OUD) produces detrimental personal and societal consequences. Astrocytes are a major cell group in the...
Link:
https://www.science.org/doi/10.1126/sciadv.abo7044
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
rats: Sprague-Dawley, Long Evans
Citation Extract:
Kruyer A, Angelis A, Garcia-Keller C, Li H, Kalivas PW. Plasticity in astrocyte subpopulations regulates heroin relapse. Sci Adv. 2022 Aug 12;8(32):eabo7044. doi: 10.1126/sciadv.abo7044. Epub 2022 Aug 10.

Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish

Authors:
Ouyang J, Li S, Sun W, Xiao X, Wang Y, Jiang Y, Zhang Q
Citation:
Clin Genet. 2022 Aug 22. doi: 10.1111/cge.14213. Online ahead of print
Epub:
Not Epub
Abstract:
High myopia is one of the most common causes for blindness due to its associated complications. Genetic factor has been...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/cge.14213
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ouyang J, Li S, Sun W, Xiao X, Wang Y, Jiang Y, Zhang Q. Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish. Clin Genet. 2022 Aug 22. doi: 10.1111/cge.14213. Online ahead of print.

Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation

Authors:
Shan B, Horton EC, Xu SC, Huntington KE, Kawano DK, Mendoza CL, Lin L, Stafford CM, Allen ED, Huang J, Nakahara H, Greenstein LE, Hille MB
Citation:
Dev Dyn. 2022 Aug 22. doi: 10.1002/dvdy.524. Online ahead of print
Epub:
Not Epub
Abstract:
Background: The cadherin-associated protein p120 catenin regulates convergent extension through interactions with cadherin...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.524
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shan B, Horton EC, Xu SC, Huntington KE, Kawano DK, Mendoza CL, Lin L, Stafford CM, Allen ED, Huang J, Nakahara H, Greenstein LE, Hille MB. Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation. Dev Dyn. 2022 Aug 22. doi: 10.1002/dvdy.524. Online ahead of print.

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