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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.28.514237 Epub:
Not Epub Abstract:
Mutations in the DMD gene are causative for Duchenne muscular dystrophy (DMD). Antisense oligonucleotide (AON) mediated exon... Delivery Method:
electroporation Organism or Cell Type:
cell culture: human myotubes, DMD and healthy sources Citation Extract: Goossens R, Verwey N, Ariyurek Y, Schnell F, Aartsma-Rus A. DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.28.514237. |
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin
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Citation:
Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239. Epub 2022 Oct 28 Epub:
Not Epub Abstract:
Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ha J, Kim BS, Min B, Nam J, Lee JG, Lee M, Yoon BH, Choi YH, Im I, Park JS, Choi H, Baek A, Cho SM, Lee MO, Nam KH, Mun JY, Kim M, Kim SY, Son MY, Kang YK, Lee JS, Kim JK, Kim J. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239. Epub 2022 Oct 28. |
Embryonic microRNAs are essential for bovine preimplantation embryo development
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Citation:
Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212942119. doi: 10.1073/pnas.2212942119. Epub 2022 Nov 2 Epub:
Not Epub Abstract:
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression after transcription. miRNAs are present in... Delivery Method:
microinjection Organism or Cell Type:
Bos taurus (cattle) embryo Citation Extract: Paulson EE, Fishman EL, Schultz RM, Ross PJ. Embryonic microRNAs are essential for bovine preimplantation embryo development. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212942119. doi: 10.1073/pnas.2212942119. Epub 2022 Nov 2. |
The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons
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Citation:
PLoS Biol. 2022;20(11):e3001838. doi:10.1371/journal.pbio.3001838 Epub:
Not Epub Abstract:
Host-associated microbiotas guide the trajectory of developmental programs, and altered microbiota composition is linked to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bruckner JJ, Stednitz SJ, Grice MZ, Zaidan D, Massaquoi MS, Larsch J, Tallafuss A, Guillemin K, Washbourne P, Eisen JS. The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons. PLoS Biol. 2022;20(11):e3001838. doi:10.1371/journal.pbio.3001838. |
Artificial Control of the Prunus Self-incompatibility System Using Antisense Oligonucleotides Against Pollen Genes
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Citation:
Hort J. 2022;91(4):437-47. doi:10.2503/hortj.QH-002 Epub:
Not Epub Abstract:
Prunus (Rosaceae) includes many commercially important fruit crop species that exhibit self-incompatibility (SI), including... Delivery Method:
pollen bathing Organism or Cell Type:
Prunus sp. pollen Citation Extract: Ono K, Masui K, Tao R. Artificial Control of the Prunus Self-incompatibility System Using Antisense Oligonucleotides Against Pollen Genes. Hort J. 2022;91(4):437-47. doi:10.2503/hortj.QH-002. |
ASO targeting temperature-controlled RBM3 poison exon splicing prevents neurodegeneration in vivo
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.26.513170 Epub:
Not Epub Abstract:
Neurodegenerative diseases become increasingly prevalent in the aging population and currently no cure is available. Increasing... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: HEK293 Citation Extract: Preußner M, Smith HL, Zhang M, Hughes D, Emmerichs A-K, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR, Heyd F
. ASO targeting temperature-controlled RBM3 poison exon splicing prevents neurodegeneration in vivo. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.26.513170. |
Eteplirsen Use in a Boy with Duchenne Muscular Dystrophy and Sickle Cell Anemia
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Citation:
Case Rep Neurol. 2022;14:404-7. doi:10.1159/000527358 Epub:
Not Epub Abstract:
Eteplirsen is an antisense oligonucleotide used in the treatment of Duchenne muscular dys-
trophy (DMD). The safety of... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Aiello GM, Cartwright MS. Eteplirsen Use in a Boy with Duchenne Muscular Dystrophy and Sickle Cell Anemia. Case Rep Neurol. 2022;14:404-7. doi:10.1159/000527358. |
Non-additive mixture effects of benzo[a]pyrene and pesticides in vitro and in vivo: Role of AhR signaling
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Citation:
Environ Pollut. 2022 Oct 25:120510. doi: 10.1016/j.envpol.2022.120510. Online ahead of print Epub:
Yes Abstract:
Polycyclic aromatic hydrocarbons (PAHs) and pesticides are two major groups of environmental contaminants which humans are... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Endirlik B Ü, E Wincent, K Dreij. Non-additive mixture effects of benzo[a]pyrene and pesticides in vitro and in vivo: Role of AhR signaling. Environ Pollut. 2022 Oct 25:120510. doi: 10.1016/j.envpol.2022.120510. Online ahead of print. |
The Potential Protective Effect and Underlying Mechanisms of Physiological Unconjugated Hyperbilirubinemia Mediated by UGT1A1 Antisense Oligonucleotide Therapy in a Mouse Model of Cyclosporine A-Induced Chronic Kidney Disease
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Citation:
Metabolites. 2022 Oct 20;12(10):999. doi: 10.3390/metabo12100999 Epub:
Not Epub Abstract:
Cyclosporine A (CSA) is an immunosuppressive drug that has improved transplant survival rates. However, its use is often... Delivery Method:
i.v. injection Organism or Cell Type:
mice Citation Extract: Marghani BH, El-Adl M, Ateya AI, Othman BH, Ghamry HI, Shukry M, Soliman MM, Rizk MA. The Potential Protective Effect and Underlying Mechanisms of Physiological Unconjugated Hyperbilirubinemia Mediated by UGT1A1 Antisense Oligonucleotide Therapy in a Mouse Model of Cyclosporine A-Induced Chronic Kidney Disease. Metabolites. 2022 Oct 20;12(10):999. doi: 10.3390/metabo12100999. |
Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming
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Citation:
Nat Phys. 2022;[Epub ahead of print] doi:10.1038/s41567-022-01787-6 Epub:
Yes Abstract:
Embryo development requires biochemical signalling to generate patterns of cell fates and active mechanical forces to drive... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Pinheiro D, Kardos R, Hannezo É, Heisenberg C-P. Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. Nat Phys. 2022;[Epub ahead of print] doi:10.1038/s41567-022-01787-6. |