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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models

Authors:
Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor K, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC
Citation:
J Bone Miner Res. 2022 Sep 25. doi: 10.1002/jbmr.4711. Online ahead of print
Epub:
Not Epub
Abstract:
Bone morphogenetic protein (BMP) signaling is critical in skeletal development. Over-activation can trigger heterotopic...
Link:
https://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbmr.4711
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor K, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC. Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models. J Bone Miner Res. 2022 Sep 25. doi: 10.1002/jbmr.4711. Online ahead of print.

Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona

Authors:
Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard B, Oka K, Heisenberg C-P, Hotta K
Citation:
Development. 2022;149(21):dev200215. doi:10.1242/dev.200215
Epub:
Not Epub
Abstract:
Ventral tail bending, which is transient but pronounced, is found in many chordate embryos and constitutes an interesting model...
Link:
https://journals.biologists.com/dev/article/149/21/dev200215/278081/Admp-regulates-tail-bending-by-controlling-ventral
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (ascidian)
Citation Extract:
Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard B, Oka K, Heisenberg C-P, Hotta K. Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona. Development. 2022;149(21):dev200215. doi:10.1242/dev.200215.

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart

Authors:
Müller M, Eghbalian R, Boeckel J-N, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins BD, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B
Citation:
Nat Commun. 2022;13:6209. doi:10.1038/s41467-022-33658-2
Epub:
Not Epub
Abstract:
To adapt to changing hemodynamic demands, regulatory mechanisms modulate actin-myosin-kinetics by calcium-dependent and -...
Link:
https://www.nature.com/articles/s41467-022-33658-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Müller M, Eghbalian R, Boeckel J-N, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins BD, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B. NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nat Commun. 2022;13:6209. doi:10.1038/s41467-022-33658-2.

Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins

Authors:
Davidson PL, Guo H, Swart JS, Massri AJ, Edgar A, Wang L, Berrio A, Devens HR, Koop D, Cisternas P, Zhang H, Zhang Y, Byrne M, Fan G, Wray GA
Citation:
Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01906-9
Epub:
Not Epub
Abstract:
Changes in developmental gene regulatory networks (dGRNs) underlie much of the diversity of life, but the evolutionary...
Link:
https://www.nature.com/articles/s41559-022-01906-9
Delivery Method:
microinjection
Organism or Cell Type:
Heliocidaris erythrogramma (sea urchin)
Citation Extract:
Davidson PL, Guo H, Swart JS, Massri AJ, Edgar A, Wang L, Berrio A, Devens HR, Koop D, Cisternas P, Zhang H, Zhang Y, Byrne M, Fan G, Wray GA. Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins. Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01906-9.

Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells

Authors:
Zhang R, Tu YX, Ye D, Gu Z, Chen ZX, Sun Y
Citation:
Adv Sci (Weinh). 2022 Oct 18:e2203631. doi: 10.1002/advs.202203631. Online ahead of print
Epub:
Not Epub
Abstract:
Maintenance and differentiation of germline stem and progenitor cells (GSPCs) is important for sexual reproduction. Here, the...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202203631
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang R, Tu YX, Ye D, Gu Z, Chen ZX, Sun Y. Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Adv Sci (Weinh). 2022 Oct 18:e2203631. doi: 10.1002/advs.202203631. Online ahead of print.

5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

Authors:
Zhang Y, Zhang L-S, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J
Citation:
Proc Nat Acad Sci USA. 2022;119(42):e2123338119 doi:10.1073/pnas.2123338119
Epub:
Not Epub
Abstract:
5-methylcytosine (m5C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear...
Link:
https://www.pnas.org/doi/abs/10.1073/pnas.2123338119
Delivery Method:
Vivo-Morpholino intranasal & i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Zhang Y, Zhang L-S, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J. 5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons. Proc Nat Acad Sci USA. 2022;119(42):e2123338119 doi:10.1073/pnas.2123338119.

Brain milieu induces early microglial maturation through the BAX-Notch axis

Authors:
Zhao F, He J, Tang J, Cui N, Shi Y, Li Z, Liu S, Wang Y, Ma M, Zhao C, Luo L, Li L
Citation:
Nat Commun. 2022;13(1):6117. doi:10.1038/s41467-022-33836-2
Epub:
Not Epub
Abstract:
Microglia are derived from primitive myeloid cells and gain their early identity in the embryonic brains. However, the...
Link:
https://www.nature.com/articles/s41467-022-33836-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao F, He J, Tang J, Cui N, Shi Y, Li Z, Liu S, Wang Y, Ma M, Zhao C, Luo L, Li L. Brain milieu induces early microglial maturation through the BAX-Notch axis. Nat Commun. 2022;13(1):6117. doi:10.1038/s41467-022-33836-2.

P.198 Durable AOC mediated exon 44 skipping in non-human primate muscle tissue and dystrophin protein restoration in DMD patient derived skeletal muscle cells

Authors:
Karamanlidis G, Etxaniz U, Missinato M, Diaz M, Bhardwaj R, Tyaglo O, Lemoine K, Marks I, Albin T, Leung L, Kovach P, Anderson A, Cochran M, Huan H, Younis H, Flanagan M, Levin A
Citation:
Neuromuscul Disord. 2022;32(Suppl 1):S127. doi:10.1016/j.nmd.2022.07.353
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by predominantly out-of-frame mutations in the dystrophin...
Link:
https://www.sciencedirect.com/science/article/pii/S0960896622005557
Delivery Method:
antibody-linked
Organism or Cell Type:
cell culture: patient-derived skeletal muscle, nonhuman primates
Citation Extract:
Karamanlidis G, Etxaniz U, Missinato M, Diaz M, Bhardwaj R, Tyaglo O, Lemoine K, Marks I, Albin T, Leung L, Kovach P, Anderson A, Cochran M, Huan H, Younis H, Flanagan M, Levin A. P.198 Durable AOC mediated exon 44 skipping in non-human primate muscle tissue and dystrophin protein restoration in DMD patient derived skeletal muscle cells. Neuromuscul Disord. 2022;32(Suppl 1):S127. doi:10.1016/j.nmd.2022.07.353.

P.194 Development of a novel, EEV-Conjugated PMO for Duchenne muscular dystrophy

Authors:
Kreher N, Kumar A, Hicks A, Peddigari S, Li X, Pathak A, Kheirabadi M, K. Kamer, Estrella N, Dougherty P, Lian W, Liu N, Gao N, Wang D, Streeter M, Dhanabal M, Qian Z, Girgenrath M, Sethuraman N
Citation:
Neuromuscul Disord. 2022;32(Suppl 1):S126. doi:10.1016/j.nmd.2022.07.349
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a rare, X-linked neuromuscular disorder caused by frameshift mutations in the DMD gene...
Link:
https://www.sciencedirect.com/science/article/pii/S096089662200551X
Delivery Method:
i.v. injection
Organism or Cell Type:
mice, nonhuman primates
Citation Extract:
Kreher N, Kumar A, Hicks A, Peddigari S, Li X, Pathak A, Kheirabadi M, K. Kamer, Estrella N, Dougherty P, Lian W, Liu N, Gao N, Wang D, Streeter M, Dhanabal M, Qian Z, Girgenrath M, Sethuraman N. P.194 Development of a novel, EEV-Conjugated PMO for Duchenne muscular dystrophy. Neuromuscul Disord. 2022;32(Suppl 1):S126. doi:10.1016/j.nmd.2022.07.349.

VP.58 Golodirsen induced DMD transcripts localization and dystrophin production in MyoD-converted fibroblasts from 4053-101 clinical trial patients

Authors:
Rossi R, Moore M, Torelli S, Ala P, Catapano F, Phadke R, Morgan J, Malhotra J, Muntoni F
Citation:
Neuromuscul Disord. 2022;32(Suppl 1):S103. doi:10.1016/j.nmd.2022.07.252
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (AONs) are short, synthetic nucleic acid sequences that work by modulating exon incorporation at the...
Link:
https://www.sciencedirect.com/science/article/pii/S0960896622004540
Delivery Method:
i.v. infusion
Organism or Cell Type:
cell culture: patient-derived fibroblasts, humans
Citation Extract:
Rossi R, Moore M, Torelli S, Ala P, Catapano F, Phadke R, Morgan J, Malhotra J, Muntoni F. VP.58 Golodirsen induced DMD transcripts localization and dystrophin production in MyoD-converted fibroblasts from 4053-101 clinical trial patients. Neuromuscul Disord. 2022;32(Suppl 1):S103. doi:10.1016/j.nmd.2022.07.252.

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