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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development

Authors:
Rankin SA, Zorn AM
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.495914
Epub:
Not Epub
Abstract:
Ventx2 is an antennapedia superfamily / NKL subclass homeodomain transcription factor best known for its role in the regulation...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.13.495914v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Rankin SA, Zorn AM. The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.495914.

Modulation of CD22 protein expression in childhood leukemia by pervasive splicing aberrations: Implications for CD22-directed immunotherapies [abstract]

Authors:
Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallières M, Hottman DA, Bagashev A, Chukinas JA, Schmidt C, Asnani MM, Shraim R, Taylor DM, Rheingold SR, O’Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A
Citation:
Cancer Res. 2022;82(12_Suppl):Abstract nr 6248. doi:10.1158/1538-7445.AM2022-6248
Epub:
Not Epub
Abstract:
Downregulation of surface epitopes causes post-immunotherapy relapses in B-lymphoblastic leukemia (B-ALL). Here we demonstrate...
Link:
https://aacrjournals.org/cancerres/article/82/12_Supplement/6248/704606
Organism or Cell Type:
cell culture
Citation Extract:
Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallières M, Hottman DA, Bagashev A, Chukinas JA, Schmidt C, Asnani MM, Shraim R, Taylor DM, Rheingold SR, O’Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A. Modulation of CD22 protein expression in childhood leukemia by pervasive splicing aberrations: Implications for CD22-directed immunotherapies [abstract]. Cancer Res. 2022;82(12_Suppl):Abstract nr 6248. doi:10.1158/1538-7445.AM2022-6248.

Hnf1b renal expression directed by a distal enhancer responsive to Pax8

Authors:
Goea L, Buisson I, Bello V, Eschstruth A, Paces-Fessy M, Le Bouffant R, Chesneau A, Cereghini S, Riou JF. Umbhauer M
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.14.496053
Epub:
Not Epub
Abstract:
Xenopus provides a simple and efficient model system to study nephrogenesis and explore the mechanisms causing renal...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.14.496053v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Goea L, Buisson I, Bello V, Eschstruth A, Paces-Fessy M, Le Bouffant R, Chesneau A, Cereghini S, Riou JF. Umbhauer M. Hnf1b renal expression directed by a distal enhancer responsive to Pax8. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.14.496053.

A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish

Authors:
Naylor RWW, Lemarie E, Jackson-Crawford A, Davenport JB, Mironov A, Lowe M, Lennon R
Citation:
Kidney Int. 2022;[Epub] doi:10.1016/j.kint.2022.05.019
Epub:
Yes
Abstract:
The zebrafish is an important animal system for modelling human diseases. This includes kidney dysfunction as the embryonic...
Link:
https://www.sciencedirect.com/science/article/pii/S0085253822004525
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Naylor RWW, Lemarie E, Jackson-Crawford A, Davenport JB, Mironov A, Lowe M, Lennon R. A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish. Kidney Int. 2022;[Epub] doi:10.1016/j.kint.2022.05.019.

Ultrasensitive detection of exosomal miRNA with PMO-graphene quantum dots-functionalized field-effect transistor biosensor

Authors:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao MM, Zhang ZY, Zhang GJ
Citation:
iScience. 2022 Jun 3;25(7):104522. doi: 10.1016/j.isci.2022.104522. eCollection 2022 Jul 15.
Epub:
Not Epub
Abstract:
Compared with the conventional DNA probe immobilization on the planar surface, nanoparticles-based DNA probes enable more RNA...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(22)00793-3
Citation Extract:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao MM, Zhang ZY, Zhang GJ. Ultrasensitive detection of exosomal miRNA with PMO-graphene quantum dots-functionalized field-effect transistor biosensor. iScience. 2022 Jun 3;25(7):104522. doi: 10.1016/j.isci.2022.104522. eCollection 2022 Jul 15..

CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development

Authors:
Klaus A, Clapes T, Yvernogeau L, Basu S, Weijts B, Maas J, Smal I, Galjart N, Robin C
Citation:
Cell Rep. 2022 Jun 14;39(11):110957. doi: 10.1016/j.celrep.2022.110957
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) express a large variety of cell surface receptors that are associated with acquisition of self-...
Link:
https://www.cell.com/cell-reports/pdfExtended/S2211-1247(22)00739-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Klaus A, Clapes T, Yvernogeau L, Basu S, Weijts B, Maas J, Smal I, Galjart N, Robin C. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development. Cell Rep. 2022 Jun 14;39(11):110957. doi: 10.1016/j.celrep.2022.110957.

Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix

Authors:
Norcross RG, Abdelmoti L, Rouchka EC, Andreeva K, Tussey O, Landestoy D, Galperin E
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.495941
Epub:
Not Epub
Abstract:
The extracellular signal-regulated kinase (ERK1/2) pathway is essential in embryonic development. The scaffold protein Shoc2 is...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.13.495941v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Norcross RG, Abdelmoti L, Rouchka EC, Andreeva K, Tussey O, Landestoy D, Galperin E. Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.495941 .

MNK2 deficiency potentiates β-cell regeneration via translational regulation

Authors:
Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, Liu X, Chu L, Locasale JW, Korbutt GS, Rovira M, Larsson O, Andersson O
Citation:
Nat Chem Biol. 2022 Jun 13. doi: 10.1038/s41589-022-01047-x. Online ahead of print
Epub:
Not Epub
Abstract:
Regenerating pancreatic β-cells is a potential curative approach for diabetes. We previously identified the small molecule...
Link:
https://www.nature.com/articles/s41589-022-01047-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, Liu X, Chu L, Locasale JW, Korbutt GS, Rovira M, Larsson O, Andersson O. MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nat Chem Biol. 2022 Jun 13. doi: 10.1038/s41589-022-01047-x. Online ahead of print.

Downregulation of Yap1 During Limb Regeneration Results in Defective Bone Formation in Axolotl

Authors:
Bay S, Öztürk G, Emekli N, Demircan T
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.12.495807
Epub:
Not Epub
Abstract:
The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.12.495807v1
Delivery Method:
injection then electroporation
Organism or Cell Type:
Ambystoma mexicanum (axlotl)
Citation Extract:
Bay S, Öztürk G, Emekli N, Demircan T. Downregulation of Yap1 During Limb Regeneration Results in Defective Bone Formation in Axolotl. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.12.495807.

Helix-Stabilized Cell-Penetrating Peptides for Delivery of Antisense Morpholino Oligomers: Relationships among Helicity, Cellular Uptake, and Antisense Activity

Authors:
Takada H, Tsuchiya K, Demizu Y
Citation:
Bioconjug Chem. 2022 Jun 23. doi: 10.1021/acs.bioconjchem.2c00199. Online ahead of print
Epub:
Yes
Abstract:
The secondary structures of cell-penetrating peptides (CPPs) influence their properties including their cell-membrane...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00199
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa 705
Citation Extract:
Takada H, Tsuchiya K, Demizu Y. Helix-Stabilized Cell-Penetrating Peptides for Delivery of Antisense Morpholino Oligomers: Relationships among Helicity, Cellular Uptake, and Antisense Activity. Bioconjug Chem. 2022 Jun 23. doi: 10.1021/acs.bioconjchem.2c00199. Online ahead of print.

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