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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12351 scientific papers returned from the database with the search filters currently being used below.

Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs

Authors:
Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A
Citation:
Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9
Epub:
Not Epub
Abstract:
CAG trinucleotide repeat expansions cause several neurodegenerative diseases, including Huntington's disease and...
Link:
https://www.pnas.org/doi/abs/10.1073/pnas.2215071120
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: U-2OS cells (ATCC, HTB-96)
Citation Extract:
Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A. Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9.

Hydrozoan sperm-specific SPKK motif-containing histone H2B variants stabilise chromatin with limited compaction

Authors:
Török A, Browne MJG, Vilar JC, Patwal I, DuBuc TQ, Febrimarsa, Atcheson E, Frank U, Gornik SG, Flaus A
Citation:
Development. 2023 Jan 1;150(1):dev201058. doi: 10.1242/dev.201058. Epub 2023 Jan 12
Epub:
Not Epub
Abstract:
Many animals achieve sperm chromatin compaction and stabilisation by replacing canonical histones with sperm nuclear basic...
Link:
https://journals.biologists.com/dev/article/150/1/dev201058/286546/Hydrozoan-sperm-specific-SPKK-motif-containing
Delivery Method:
microinjection
Organism or Cell Type:
Hydractinia symbiolongicarpus (cnidarian)
Citation Extract:
Török A, Browne MJG, Vilar JC, Patwal I, DuBuc TQ, Febrimarsa, Atcheson E, Frank U, Gornik SG, Flaus A. Hydrozoan sperm-specific SPKK motif-containing histone H2B variants stabilise chromatin with limited compaction. Development. 2023 Jan 1;150(1):dev201058. doi: 10.1242/dev.201058. Epub 2023 Jan 12.

C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity

Authors:
Das A, Ghosh A, Sinha S
Citation:
Org Biomol Chem. 2023 Jan 12. doi: 10.1039/d2ob01759h. Online ahead of print
Epub:
Not Epub
Abstract:
C5-substituted uridine and cytidine morpholino chlorophosphoramidate monomers were synthesized and incorporated into a 12-mer...
Link:
https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB01759H
Citation Extract:
Das A, Ghosh A, Sinha S. C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity. Org Biomol Chem. 2023 Jan 12. doi: 10.1039/d2ob01759h. Online ahead of print.

Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs

Authors:
Kawada R, Jonouchi T, Kagita A, Sato M, Hotta A, Sakurai H
Citation:
Sci Rep. 2023 Jan 11;13(1):94. doi: 10.1038/s41598-022-26614-z
Epub:
Not Epub
Abstract:
Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats (CTGexp) in the dystrophia myotonica protein kinase (DMPK)...
Link:
https://www.nature.com/articles/s41598-022-26614-z
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: patient-derived iPSCs differentiated to myotubes
Citation Extract:
Kawada R, Jonouchi T, Kagita A, Sato M, Hotta A, Sakurai H. Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs. Sci Rep. 2023 Jan 11;13(1):94. doi: 10.1038/s41598-022-26614-z.

maea affects head formation through ß-catenin degradation during early Xenopus laevis development

Authors:
Goto T, Shibuya H
Citation:
Dev Growth Differ. 2022 Nov 28. doi: 10.1111/dgd.12828. Online ahead of print
Epub:
Not Epub
Abstract:
Canonical Wnt signalling plays important roles in early embryogenesis, such as axis formation due to its activation and head...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/dgd.12828
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Goto T, Shibuya H. maea affects head formation through ß-catenin degradation during early Xenopus laevis development. Dev Growth Differ. 2022 Nov 28. doi: 10.1111/dgd.12828. Online ahead of print.

Distinct biogenesis pathways may have led to functional divergence of the human and Drosophila Arglu1 sisRNA

Authors:
Chan SN, Pek JW
Citation:
EMBO Rep. 2022 Dec 19:e54350. doi: 10.15252/embr.202154350. Online ahead of print
Epub:
Not Epub
Abstract:
Stable intronic sequence RNAs (sisRNAs) are stable, long noncoding RNAs containing intronic sequences. While sisRNAs have been...
Link:
https://www.embopress.org/doi/abs/10.15252/embr.202154350
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: MDA-MB-231 and HEK293T
Citation Extract:
Chan SN, Pek JW. Distinct biogenesis pathways may have led to functional divergence of the human and Drosophila Arglu1 sisRNA. EMBO Rep. 2022 Dec 19:e54350. doi: 10.15252/embr.202154350. Online ahead of print.

SCGN deficiency is a risk factor for autism spectrum disorder

Authors:
Liu Z, Tan S, Zhou L, Chen L, Liu M, Wang W, Tang Y, Yang Q, Chi S, Jiang P, Zhang Y, Cui Y, Qin J, Hu X, Li S, Liu Q, Chen L, Li S, Burstein E, Li W, Zhang X, Mo X, Jia D
Citation:
Signal Transduct Target Ther. 2023 Jan 2;8(1):3. doi: 10.1038/s41392-022-01225-2
Epub:
Not Epub
Abstract:
Autism spectrum disorder (ASD) affects 1-2% of all children and poses a great social and economic challenge for the globe. As a...
Link:
https://www.nature.com/articles/s41392-022-01225-2
Organism or Cell Type:
zebrafish
Citation Extract:
Liu Z, Tan S, Zhou L, Chen L, Liu M, Wang W, Tang Y, Yang Q, Chi S, Jiang P, Zhang Y, Cui Y, Qin J, Hu X, Li S, Liu Q, Chen L, Li S, Burstein E, Li W, Zhang X, Mo X, Jia D. SCGN deficiency is a risk factor for autism spectrum disorder. Signal Transduct Target Ther. 2023 Jan 2;8(1):3. doi: 10.1038/s41392-022-01225-2.

Morpholino Mediated Gene Editing: A Gene Knockdown Technique Using Translational Blocking Morpholino Oligonucleotides in Single-Celled Cavefish Eggs

Authors:
JoVE staff (?) - this information paywalled
Citation:
JoVE Encyclopedia of Experiments: Biological Techniques. JoVE, Cambridge, MA, (2022?)
Epub:
Not Epub
Abstract:
paywalled
Link:
https://www.jove.com/v/21011/morpholino-mediated-gene-editing-a-gene-knockdown-technique-using-translational-blocking-morpholino-oligonucleotides-in-single-celled-cavefish-eggs
Delivery Method:
microinjection
Organism or Cell Type:
cavefish
Citation Extract:
JoVE staff (?) - this information paywalled. Morpholino Mediated Gene Editing: A Gene Knockdown Technique Using Translational Blocking Morpholino Oligonucleotides in Single-Celled Cavefish Eggs. JoVE Encyclopedia of Experiments: Biological Techniques. JoVE, Cambridge, MA, (2022?).

Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells

Authors:
Leung AO, Yiu TC, Liu L, Tam HY, Gu S, Tu J, Pei D, Cheung HH
Citation:
Cell Biosci. 2022 Dec 31;12(1):212. doi: 10.1186/s13578-022-00939-8
Epub:
Not Epub
Abstract:
Background: Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging...
Link:
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-022-00939-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Leung AO, Yiu TC, Liu L, Tam HY, Gu S, Tu J, Pei D, Cheung HH. Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells. Cell Biosci. 2022 Dec 31;12(1):212. doi: 10.1186/s13578-022-00939-8.

Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish

Authors:
Saralahti AK, Harjula S-KE, Rantapero T, Uusi-Mäkelä MIE, Kaasinen M, Junno M, Piippo H, Nykter M, Lohi O, Rounioja S, Parikka M, Rämet M
Citation:
PLoS Genet. 2023;19(1):e1010586. doi:10.1371/journal.pgen.1010586
Epub:
Not Epub
Abstract:
Streptococcus pneumoniae (pneumococcus) is one of the most frequent causes of pneumonia, sepsis and meningitis in humans, and...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010586
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Saralahti AK, Harjula S-KE, Rantapero T, Uusi-Mäkelä MIE, Kaasinen M, Junno M, Piippo H, Nykter M, Lohi O, Rounioja S, Parikka M, Rämet M. Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genet. 2023;19(1):e1010586. doi:10.1371/journal.pgen.1010586.

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