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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo

Authors:
Truszkowski L, Batur D, Long H, Tarbashevich K, Vos BE, Trappmann B, Raz E
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.02.514858
Epub:
Not Epub
Abstract:
In both physiological processes and disease contexts, migrating cells have the ability to adapt to conditions in their...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.02.514858v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Truszkowski L, Batur D, Long H, Tarbashevich K, Vos BE, Trappmann B, Raz E. Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.02.514858.

Rab8-, Rab11-, and Rab35-dependent mechanisms coordinating lumen and cilia formation during Left-Right Organizer development

Authors:
Aljiboury AA, Ingram E, Krishnan N, Ononiwu F, Pal D, Manikas J, Taveras C, Hall NA, Da Silva J, Freshour J, Hehnly H
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.31.514532
Epub:
Not Epub
Abstract:
An essential process for cilia formation during epithelialization is the movement of the centrosome to dock with the cell’s...
Link:
https://www.biorxiv.org/content/10.1101/2022.10.31.514532v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Aljiboury AA, Ingram E, Krishnan N, Ononiwu F, Pal D, Manikas J, Taveras C, Hall NA, Da Silva J, Freshour J, Hehnly H. Rab8-, Rab11-, and Rab35-dependent mechanisms coordinating lumen and cilia formation during Left-Right Organizer development. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.31.514532.

Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS

Authors:
Seo Y, Mo S, Kim S, Kim H, Park H-C
Citation:
Int J Mol Sci. 2022. 23:13395. doi:10.3390/ijms232113395
Epub:
Not Epub
Abstract:
Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and...
Link:
https://www.mdpi.com/1422-0067/23/21/13395/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Seo Y, Mo S, Kim S, Kim H, Park H-C. Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. Int J Mol Sci. 2022. 23:13395. doi:10.3390/ijms232113395.

Homologous gene regulatory networks control development of apical organs and brains in Bilateria

Authors:
Feuda R, Peter IS
Citation:
Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2
Epub:
Not Epub
Abstract:
Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the...
Link:
https://www.science.org/doi/10.1126/sciadv.abo2416
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Feuda R, Peter IS. Homologous gene regulatory networks control development of apical organs and brains in Bilateria. Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2.

Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands

Authors:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW
Citation:
Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print
Epub:
Not Epub
Abstract:
Wnt11 family proteins are ligands that activate a type of Dishevelled-mediated, non-canonical Wnt signaling pathway. Loss of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160622002020
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print.

Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development

Authors:
Kolas V, Mathieu G, Wu YT, Chung BC
Citation:
Biochem Biophys Res Commun. 2022 Oct 21;636(Pt 1):84-88. doi:10.1016/j.bbrc.2022.10.067. Online ahead of print
Epub:
Not Epub
Abstract:
Pregnenolone (P5) is a steroid that functions in the brain and in zebrafish embryogenesis. It is synthesized from cholesterol...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22014693
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kolas V, Mathieu G, Wu YT, Chung BC. Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development. Biochem Biophys Res Commun. 2022 Oct 21;636(Pt 1):84-88. doi:10.1016/j.bbrc.2022.10.067. Online ahead of print.

Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro

Authors:
Catasús N, Rosas I, Bonache S, Negro A, Torres-Martin M, Plana-Pla A, Salvador H, Serra E, Blanco I, Castellanos E, on behalf of the NF2-related SWN Spanish National Reference Centre HUGTP-ICO-IGTP
Citation:
Mol Ther Nucleic Acids. 2022 Nov 4;30:493-505. doi: 10.1016/j.omtn.2022.10.026. eCollection 2022 Dec 13.
Epub:
Not Epub
Abstract:
NF2-related schwannomatosis (NF2-related SWN) is an autosomal dominant condition caused by loss of function variants in the NF2...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00293-1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human patient-derived fibroblasts
Citation Extract:
Catasús N, Rosas I, Bonache S, Negro A, Torres-Martin M, Plana-Pla A, Salvador H, Serra E, Blanco I, Castellanos E, on behalf of the NF2-related SWN Spanish National Reference Centre HUGTP-ICO-IGTP. Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro. Mol Ther Nucleic Acids. 2022 Nov 4;30:493-505. doi: 10.1016/j.omtn.2022.10.026. eCollection 2022 Dec 13..

Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy

Authors:
Gushchina LV, Vetter TA, Frair EC, Bradley AJ, Grounds KM, Lay JW, Huang N, Suhaiba A, Schnell FJ, Hanson G, Simmons TR, Wein N, Flanigan KM
Citation:
Mol Ther Nucleic Acids. 2022 Nov 9;30:479-492. doi: 10.1016/j.omtn.2022.10.025. eCollection 2022 Dec 13.
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease that arises due to the loss of dystrophin expression...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(22)00291-8.pdf
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Gushchina LV, Vetter TA, Frair EC, Bradley AJ, Grounds KM, Lay JW, Huang N, Suhaiba A, Schnell FJ, Hanson G, Simmons TR, Wein N, Flanigan KM. Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy. Mol Ther Nucleic Acids. 2022 Nov 9;30:479-492. doi: 10.1016/j.omtn.2022.10.025. eCollection 2022 Dec 13..

Expression patterns and biological function of BCL2L10 during mouse preimplantation development

Authors:
Liu Y, Xin J, Zhang S, Li Q, Wang W, Chen J, Ming X, Wu X, Cao X, Cui W, Wang H, Li W
Citation:
Gene Expr Patterns. 2022;46:119285. doi:10.1016/j.gep.2022.119285
Epub:
Not Epub
Abstract:
BCL2-like 10 (BCL2L10) is abundantly expressed in mammalian oocytes and plays a crucial role in the completion of oocyte...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1567133X22000552
Delivery Method:
microinjection
Organism or Cell Type:
mouse pronuclear embryo
Citation Extract:
Liu Y, Xin J, Zhang S, Li Q, Wang W, Chen J, Ming X, Wu X, Cao X, Cui W, Wang H, Li W. Expression patterns and biological function of BCL2L10 during mouse preimplantation development. Gene Expr Patterns. 2022;46:119285. doi:10.1016/j.gep.2022.119285.

Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo

Authors:
Ventura G, Amiri A, Thiagarajan R, Tolonen M, Doostmohammadi A, Sedzinski J
Citation:
Nat Commun. 2022 Oct 28;13(1):6423. doi: 10.1038/s41467-022-34165-0
Epub:
Not Epub
Abstract:
During embryonic development, regeneration, and homeostasis, cells have to migrate and physically integrate into the target...
Link:
https://www.nature.com/articles/s41467-022-34165-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ventura G, Amiri A, Thiagarajan R, Tolonen M, Doostmohammadi A, Sedzinski J. Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo. Nat Commun. 2022 Oct 28;13(1):6423. doi: 10.1038/s41467-022-34165-0.

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