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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Antisense pre-treatment increases gene therapy efficacy in dystrophic muscles
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Citation:
Hum Mol Genet. 2016 Jul 4. pii: ddw201. [Epub ahead of print] Epub:
Yes Abstract:
In preclinical models for Duchenne muscular dystrophy, dystrophin restoration during AAV-U7-mediated exon-skipping therapy was... Delivery Method:
injection Organism or Cell Type:
mice, mdx Citation Extract: Peccate C, Mollard A, Le Hir M, Julien L, McClorey G, Jarmin S, Le Heron A, Dickson G, Benkhelifa-Ziyyat S, Piétri-Rouxel F, Wood MJ, Voit T, Lorain S. Antisense pre-treatment increases gene therapy efficacy in dystrophic muscles. Hum Mol Genet. 2016 Jul 4. pii: ddw201. [Epub ahead of print]. |
Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis
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Citation:
Sci Rep. 2016 Jul 5;6:29157. doi: 10.1038/srep29157 Epub:
Not Epub Abstract:
Methylation of histone tails plays a pivotal role in the regulation of a wide range of biological processes. SET and MYND... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Fujii T, Tsunesumi SI, Sagara H, Munakata M, Hisaki Y, Sekiya T, Furukawa Y, Sakamoto K, Watanabe S. Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis. Sci Rep. 2016 Jul 5;6:29157. doi: 10.1038/srep29157. |
Altered Levels of MicroRNA-9, -206, and -132 in Spinal Muscular Atrophy and Their Response to Antisense Oligonucleotide Therapy
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Citation:
Mol Ther Nucleic Acids. 2016 Jul 5;5(7):e331. doi: 10.1038/mtna.2016.47 Epub:
Not Epub Abstract:
The identification of noninvasive biomarkers to monitor the disease progression in spinal muscular atrophy (SMA) is becoming... Delivery Method:
injection Organism or Cell Type:
mice Citation Extract: Catapano F, Zaharieva I, Scoto M, Marrosu E, Morgan J, Muntoni F, Zhou H. Altered Levels of MicroRNA-9, -206, and -132 in Spinal Muscular Atrophy and Their Response to Antisense Oligonucleotide Therapy. Mol Ther Nucleic Acids. 2016 Jul 5;5(7):e331. doi: 10.1038/mtna.2016.47. |
Tbx16 regulates hox gene activation in mesodermal progenitor cells
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Citation:
Nat Chem Biol. 2016 Jul 4. doi: 10.1038/nchembio.2124. [Epub ahead of print] Epub:
Yes Abstract:
The transcription factor T-box 16 (Tbx16, or Spadetail) is an essential regulator of paraxial mesoderm development in zebrafish... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Payumo AY, McQuade LE, Walker WJ, Yamazoe S, Chen JK. Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nat Chem Biol. 2016 Jul 4. doi: 10.1038/nchembio.2124. [Epub ahead of print]. |
NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation
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Citation:
J Mol Med (Berl). 2016 Jul 1. [Epub ahead of print] Epub:
Yes Abstract:
Entry of calcium into cardiomyocyte via L-type calcium channel (LTCC) is fundamental to cardiac contraction. CACNA1C, a type of... Organism or Cell Type:
zebrafish Citation Extract: Li W, Zheng NZ, Yuan Q, Xu K, Yang F, Gu L, Zheng GY, Luo GJ, Fan C, Ji GJ, Zhang B, Cao H, Tian XL. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. J Mol Med (Berl). 2016 Jul 1. [Epub ahead of print]. |
Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination
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Citation:
Int J Ophthalmol. 2016 Jun 18;9(6):831-7. doi: 10.18240/ijo.2016.06.07. eCollection 2016 Epub:
Not Epub Abstract:
AIM: To investigate the role of tumor necrosis factor-alpha (TNF-α) in zebrafish retinal development and myelination.
METHODS... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lei XD, Sun Y, Cai SJ, Fang YW, Cui JL, Li YH. Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination. Int J Ophthalmol. 2016 Jun 18;9(6):831-7. doi: 10.18240/ijo.2016.06.07. eCollection 2016. |
Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics
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Citation:
Mol Ther. 2016 Jul 5. doi: 10.1038/mt.2016.111. [Epub ahead of print] Epub:
Not Epub Abstract:
Derepression of DUX4 in skeletal muscle has emerged as a likely cause of pathology in facioscapulohumeral muscular dystrophy (... Organism or Cell Type:
cell culture: FSHD myotubes, xenografts in mice Citation Extract: Chen JC, King OD, Zhang Y, Clayton NP, Spencer C, Wentworth BM, Emerson CP Jr, Wagner KR. Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics. Mol Ther. 2016 Jul 5. doi: 10.1038/mt.2016.111. [Epub ahead of print]. |
Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
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Citation:
Nat Comm. 2016;7:12077 doi:10.1038/ncomms12077 Epub:
Not Epub Abstract:
Inflammasomes are cytosolic molecular platforms that alert the immune system about the presence of infection. Here we report... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Tyrkalska SD, Candel S, Angosto D, Gómez-Abellán V, Martín-Sánchez F, García-Moreno D, Zapata-Pérez R, Sánchez-Ferrer A, Sepulcre MP, Pelegrín P, Mulero V. Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins. Nat Comm. 2016;7:12077 doi:10.1038/ncomms12077. |
Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis
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Citation:
Nature. 2016;534:700–4. doi:10.1038/nature18310 Epub:
Not Epub Abstract:
Many organs are composed of complex tissue walls that are structurally organized to optimize organ function. In particular, the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC. Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016;534:700–4. doi:10.1038/nature18310. |
Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice
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Citation:
Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46 Epub:
Not Epub Abstract:
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations... Delivery Method:
injection standard oligos and peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Cao L, Han G, Lin C, Gu B, Gao X, Moulton HM, Seow Y, Yin H. Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice. Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46. |