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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation

Authors:
Asad Z, Pandey A, Babu A, Sun Y, Shevade K, Kapoor S, Ullah I, Ranjan S, Scaria V, Bajpai R, Sachidanandan C
Citation:
Hum Mol Genet. 2016 Jul 13. pii: ddw198. [Epub ahead of print]
Epub:
Yes
Abstract:
CHD7 mutations are implicated in a majority of cases of the congenital disorder, CHARGE syndrome. CHARGE, an autosomal dominant...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Asad Z, Pandey A, Babu A, Sun Y, Shevade K, Kapoor S, Ullah I, Ranjan S, Scaria V, Bajpai R, Sachidanandan C. Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation. Hum Mol Genet. 2016 Jul 13. pii: ddw198. [Epub ahead of print].

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

Authors:
Reischauer S, Stone OA, Villasenor A, Chi N, Jin S-W, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung W-S, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DYR
Citation:
Nature. 2016;535:294-8. doi:10.1038/nature18614
Epub:
Not Epub
Abstract:
Vascular and haematopoietic cells organize into specialized tissues during early embryogenesis to supply essential nutrients to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reischauer S, Stone OA, Villasenor A, Chi N, Jin S-W, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung W-S, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DYR. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2016;535:294-8. doi:10.1038/nature18614.

BMP and retinoic acid regulate anterior–posterior patterning of the non-axial mesoderm across the dorsal–ventral axis

Authors:
Naylor RW, Skvarca LB, Thisse C, Thisse B, Hukriede NA, Davidson AJ
Citation:
Nat Comm. 2016;7:12197. doi:10.1038/ncomms12197
Epub:
Not Epub
Abstract:
Despite the fundamental importance of patterning along the dorsal–ventral (DV) and anterior–posterior (AP) axes during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Naylor RW, Skvarca LB, Thisse C, Thisse B, Hukriede NA, Davidson AJ. BMP and retinoic acid regulate anterior–posterior patterning of the non-axial mesoderm across the dorsal–ventral axis. Nat Comm. 2016;7:12197. doi:10.1038/ncomms12197.

Germline replacement by blastula cell transplantation in the fish medaka

Authors:
Li M, Hong N, Xu H, Song J, Yunhan Hong Y
Citation:
Sci Rep. 2016;6:29658. doi:10.1038/srep29658
Epub:
Not Epub
Abstract:
Primordial germ cell (PGC) specification early in development establishes the germline for reproduction and reproductive...
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Li M, Hong N, Xu H, Song J, Yunhan Hong Y. Germline replacement by blastula cell transplantation in the fish medaka. Sci Rep. 2016;6:29658. doi:10.1038/srep29658.

The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane

Authors:
Xu W, Jin M, Hu R, Wang H, Zhang F, Yuan S, Cao Y
Citation:
J Am Soc Nephrol. 2016 Jul 8. pii: ASN.2015080906. [Epub ahead of print]
Epub:
Yes
Abstract:
Phosphoinositides, a family of phosphorylated derivatives of phosphatidylinositol (PtdIns), are tightly regulated both...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu W, Jin M, Hu R, Wang H, Zhang F, Yuan S, Cao Y. The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. J Am Soc Nephrol. 2016 Jul 8. pii: ASN.2015080906. [Epub ahead of print].

Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy

Authors:
Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL
Citation:
Mol Ther. 2016 Jul 12. doi: 10.1038/mt.2016.145. [Epub ahead of print]
Epub:
Yes
Abstract:
Loss of Survival Motor Neuron-1 (SMN1) causes Spinal Muscular Atrophy (SMA), a devastating neurodegenerative disease. SMN2 is a...
Delivery Method:
Endo-Porter (cultures), icv (mice)
Organism or Cell Type:
iPS-derived SMA motor neurons, mice
Citation Extract:
Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL. Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. Mol Ther. 2016 Jul 12. doi: 10.1038/mt.2016.145. [Epub ahead of print].

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Authors:
Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, <authors hidden: database constraint> Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP, Ganesh SK
Citation:
Nat Genet. 2016 Jul 11. doi: 10.1038/ng.3607. [Epub ahead of print]
Epub:
Yes
Abstract:
Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. We analyzed...
Organism or Cell Type:
zebrafish
Citation Extract:
Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, <authors hidden: database constraint> Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP, Ganesh SK. Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. Nat Genet. 2016 Jul 11. doi: 10.1038/ng.3607. [Epub ahead of print].

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells

Authors:
Harhouri K, Navarro C, Baquerre C, Da Silva N, Bartoli C, Casey F, Mawuse GK, Doubaj Y, Lévy N, De Sandre-Giovannoli A
Citation:
Cells, 2016;5(3):31. doi:10.3390/cells5030031
Epub:
Not Epub
Abstract:
Progeroid laminopathies, including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: primary human dermal fibroblasts
Citation Extract:
Harhouri K, Navarro C, Baquerre C, Da Silva N, Bartoli C, Casey F, Mawuse GK, Doubaj Y, Lévy N, De Sandre-Giovannoli A. Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells. Cells, 2016;5(3):31. doi:10.3390/cells5030031.

The splicing factor SRSF1 modulates pattern formation by inhibiting transcription of tissue specific genes during embryogenesis

Authors:
Lee SH, Lee HK, Kim C, Kim YK, Ismail T, Jeong Y, Park K, Park JW, Kwon OS, Kang BS, Lee DS, Park MJ, Park DS, Lee HS
Citation:
Biochem Biophys Res Commun. 2016 Jul 7. pii: S0006-291X(16)31136-6. doi: 10.1016/j.bbrc.2016.07.021. [Epub ahead of print]
Epub:
Yes
Abstract:
Alternative splicing is a major mechanism regulating pattern of gene expression through the production of multiple mRNAs from a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Lee SH, Lee HK, Kim C, Kim YK, Ismail T, Jeong Y, Park K, Park JW, Kwon OS, Kang BS, Lee DS, Park MJ, Park DS, Lee HS. The splicing factor SRSF1 modulates pattern formation by inhibiting transcription of tissue specific genes during embryogenesis. Biochem Biophys Res Commun. 2016 Jul 7. pii: S0006-291X(16)31136-6. doi: 10.1016/j.bbrc.2016.07.021. [Epub ahead of print].

Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis

Authors:
Kenyon EJ, Luijten MN, Gill H, Li N, Rawlings M, Bull JC, Hadzhiev Y, van Steensel MA, Maher E, Mueller F
Citation:
BMC Dev Biol. 2016 Jul 8;16(1):23
Epub:
Not Epub
Abstract:
BACKGROUND: Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kenyon EJ, Luijten MN, Gill H, Li N, Rawlings M, Bull JC, Hadzhiev Y, van Steensel MA, Maher E, Mueller F. Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. BMC Dev Biol. 2016 Jul 8;16(1):23.

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