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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

PRAJA is overexpressed in glioblastoma and contributes to neural precursor development

Authors:
Shin J, Mishra V, Glasgow E, Zaidi S, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B
Citation:
Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151
Epub:
Not Epub
Abstract:
PRAJA, a RING-H2 E3 ligase, is abundantly expressed in brain tissues such as the cerebellum and frontal cortex, amongst others...
Link:
http://www.impactjournals.com/Genes&Cancer/index.php?pii=151
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shin J, Mishra V, Glasgow E, Zaidi S, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B. PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151.

Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

Authors:
Shi Z, Yang X, Li BB, Chen S, Yang L, Cheng L, Zhang T, Wang H, Zheng Y
Citation:
Birth Defects Res. 2017 Sep 29. doi: 10.1002/bdr2.1122. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Neural tube defects (NTDs), the second most frequent cause of human congenital abnormalities, are debilitating...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/bdr2.1122/abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Shi Z, Yang X, Li BB, Chen S, Yang L, Cheng L, Zhang T, Wang H, Zheng Y . Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects. Birth Defects Res. 2017 Sep 29. doi: 10.1002/bdr2.1122. [Epub ahead of print].

Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes

Authors:
Riddiford N, Schlosser G
Citation:
Dev Biol. 2017 Sep 22. pii: S0012-1606(17)30412-8. doi: 10.1016/j.ydbio.2017.09.027. [Epub ahead of print]
Epub:
Yes
Abstract:
The transcription factor Six1 and its cofactor Eya1 are important regulators of neurogenesis in cranial placodes, activating...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160617304128
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Riddiford N, Schlosser G. Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes. Dev Biol. 2017 Sep 22. pii: S0012-1606(17)30412-8. doi: 10.1016/j.ydbio.2017.09.027. [Epub ahead of print].

LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells

Authors:
Choi HJ, Rho SS, Choi DH, Kwon YG
Citation:
BMB Rep. 2017 Sep 26. pii: 3929. [Epub ahead of print]
Epub:
Yes
Abstract:
Delta-like ligand 4 (DLL4) expression in endothelial cells is intimately associated with angiogenic sprouting and vascular...
Link:
http://submit.bmbreports.org/Search/View.html?tmp_tr_num=3929
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Choi HJ, Rho SS, Choi DH, Kwon YG. LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. BMB Rep. 2017 Sep 26. pii: 3929. [Epub ahead of print].

Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis

Authors:
Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi Q, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H, Liu F, Zhao J
Citation:
Blood. 2017;[Epub ahead of print] doi:10.1182/blood-2017-05-783043
Epub:
Yes
Abstract:
Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases and is often accompanied by anemia and...
Link:
http://www.bloodjournal.org/content/early/2017/09/22/blood-2017-05-783043
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi Q, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H, Liu F, Zhao J. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017;[Epub ahead of print] doi:10.1182/blood-2017-05-783043.

Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

Authors:
Gabellini C, Gómez-Abenza E, Ibáñez-Molero S, Tupone MG, Pérez-Oliva AB, de Oliveira S, Del Bufalo D, Mulero V
Citation:
Int J Cancer. 2017;[Accepted Manuscript] doi10.1002/ijc.31075
Epub:
Yes
Abstract:
The protein bcl-xL is able to enhance the secretion of the pro-inflammatory chemokine interleukin 8 (CXCL8) in human melanoma...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/ijc.31075/abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Gabellini C, Gómez-Abenza E, Ibáñez-Molero S, Tupone MG, Pérez-Oliva AB, de Oliveira S, Del Bufalo D, Mulero V. Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model. Int J Cancer. 2017;[Accepted Manuscript] doi10.1002/ijc.31075.

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I

Authors:
El Yakoubi W, Buffin E, Cladière D, Gryaznova Y, Berengue I, Touati SA, Gómez R, Suja JA, van Deursen JM, Wassmann K
Citation:
Nat Comm. 2017;8:694. doi:10.1038/s41467-017-00774-3
Epub:
Not Epub
Abstract:
A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first...
Link:
https://www.nature.com/articles/s41467-017-00774-3
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
El Yakoubi W, Buffin E, Cladière D, Gryaznova Y, Berengue I, Touati SA, Gómez R, Suja JA, van Deursen JM, Wassmann K. Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I. Nat Comm. 2017;8:694. doi:10.1038/s41467-017-00774-3.

Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding

Authors:
Carney SM, Gomathinayagam S, Leuba SH, Trakselis MA
Citation:
J Biol Chem. 2017 Sep 22. pii: jbc.M117.814178. doi: 10.1074/jbc.M117.814178. [Epub ahead of print]
Epub:
Yes
Abstract:
Replicative hexameric helicases are thought to unwind duplex DNA by steric exclusion (SE), where one DNA strand is encircled by...
Link:
http://www.jbc.org/content/early/2017/09/22/jbc.M117.814178.long
Citation Extract:
Carney SM, Gomathinayagam S, Leuba SH, Trakselis MA. Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding. J Biol Chem. 2017 Sep 22. pii: jbc.M117.814178. doi: 10.1074/jbc.M117.814178. [Epub ahead of print].

Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis

Authors:
Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z, Xiong B
Citation:
Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397. doi: 10.1093/nar/gkx563
Epub:
Not Epub
Abstract:
Sister chromatid cohesion, mediated by cohesin complex and established by the acetyltransferases Esco1 and Esco2, is essential...
Link:
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkx563
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z, Xiong B. Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis. Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397. doi: 10.1093/nar/gkx563.

Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation

Authors:
Beigel JH, Voell J, Muñoz P, Kumar P, Brooks KM, Zhang J, Iversen P, Heald A, Wong M, Davey RT
Citation:
Br J Clin Pharmacol. 2017 Sep 20. doi: 10.1111/bcp.13405. [Epub ahead of print]
Epub:
Yes
Abstract:
AIMS: The aims of the present study were to assess the safety, tolerability and pharmacokinetics of radavirsen following single...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/bcp.13405/abstract
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Beigel JH, Voell J, Muñoz P, Kumar P, Brooks KM, Zhang J, Iversen P, Heald A, Wong M, Davey RT. Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation. Br J Clin Pharmacol. 2017 Sep 20. doi: 10.1111/bcp.13405. [Epub ahead of print].

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