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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts
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Citation:
Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116 Epub:
Yes Abstract:
Splice-switching antisense oligonucleotides (SSOs) are emerging therapeutics with two SSOs recently approved by the FDA for... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: patient-derived SMA fibroblasts Citation Extract: Tajik-Ahmadabad B, Polyzos A, Separovic F, Shabanpoor F. Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts. Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116. |
Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference
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Citation:
Neuron. 2017;95:1-15. doi:j.neuron.2017.08.023 Epub:
Not Epub Abstract:
Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the... Delivery Method:
electroporation Organism or Cell Type:
Xenopus laevis Citation Extract: Dulcis D, Lippi G, Stark CJ, Do LH, Berg DK, Spitzer NC. Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron. 2017;95:1-15. doi:j.neuron.2017.08.023. |
MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus
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Citation:
PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. [Epub ahead of print] Epub:
Not Epub Abstract:
Deletions at chromosome 2p25.3 are associated with a syndrome consisting of intellectual disability and obesity. The smallest... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A. MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. [Epub ahead of print]. |
Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome
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Citation:
Sci Rep. 2017;7:10222. doi:10.1038/s41598-017-10652-z Epub:
Not Epub Abstract:
COACH syndrome is an autosomal recessive developmental disorder, a subtype of Joubert syndrome and related disorders,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lee S-H, Nam T-S, Li W, Kim JH, Yoon W, Choi Y-D, Kim K-H, Cai H, Kim MJ, Kim C, Choy HE, Kim N, Chay KO, Kim M-K, Choi S-Y. Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome. Sci Rep. 2017;7:10222. doi:10.1038/s41598-017-10652-z. |
RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo
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Citation:
Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3 Epub:
Not Epub Abstract:
Nascent proteins can be positioned rapidly at precise subcellular locations by local protein synthesis (LPS) to facilitate... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE. RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo. Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3. |
Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos
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Citation:
Development. 2017 Aug 29. pii: dev.151720. doi: 10.1242/dev.151720. [Epub ahead of print] Epub:
Yes Abstract:
We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation neural progenitors... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Mellott DO, Thisdelle J, Burke RD. Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos. Development. 2017 Aug 29. pii: dev.151720. doi: 10.1242/dev.151720. [Epub ahead of print]. |
Dysfunction of the MDM2/p53 axis is linked to premature aging
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Citation:
J Clin Invest. 2017 Aug 28. pii: 92171. doi: 10.1172/JCI92171. [Epub ahead of print] Epub:
Yes Abstract:
The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives C, Kubisch C. Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest. 2017 Aug 28. pii: 92171. doi: 10.1172/JCI92171. [Epub ahead of print]. |
NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival
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Citation:
Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21 Epub:
Not Epub Abstract:
The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular survival. Defects in neutrophil... Organism or Cell Type:
zebrafish Citation Extract: Prince LR, Prosseda SD, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB, Sabroe I. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21. |
Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization
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Citation:
PNAS USA. 2017;[Epub ahead of print] doi:10.1073/pnas.1705338114 Epub:
Yes Abstract:
Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F, van Eeden FJM. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. PNAS USA. 2017;[Epub ahead of print] doi:10.1073/pnas.1705338114. |
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching
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Citation:
Sci Rep. 2017 Aug 25;7(1):9540. doi: 10.1038/s41598-017-10102-w Epub:
Not Epub Abstract:
Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cellular compartments. These cellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, Mpindi J, Kalloniemi O, Johansson S, Majumdar A, Lanner F, Holmgren L. The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep. 2017 Aug 25;7(1):9540. doi: 10.1038/s41598-017-10102-w. |