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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle
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Citation:
Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7 Epub:
Not Epub Abstract:
Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense... Delivery Method:
injection, retro-orbital Organism or Cell Type:
Mice, C57Bl/10ScSn-mdx/J or C57Bl/10ScSnJ (Bl10 or wild-type) Citation Extract: Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA. Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7. |
Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration
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Citation:
Antioxid Redox Signal. 2017 Oct 17. doi: 10.1089/ars.2017.7166. [Epub ahead of print] Epub:
Yes Abstract:
AIMS: Redox active ultrafine particles (UFP, d < 0.2 µm) promote vascular oxidative stress and atherosclerosis. Notch... Organism or Cell Type:
zebrafish Citation Extract: Baek KI, Packard RR, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal. 2017 Oct 17. doi: 10.1089/ars.2017.7166. [Epub ahead of print]. |
hace1 influences zebrafish cardiac development via ROS-dependent mechanisms
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Citation:
Dev Dyn. 2017 Oct 11. doi: 10.1002/dvdy.24600. [Epub ahead of print] Epub:
Yes Abstract:
BACKGROUND: In this study we reveal a previously undescribed role of the HACE1 (HECT domain and Ankyrin repeat Containing E3... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, Chacko S, Lewis S, Scott IC, Sorensen PHB, Berman JN. hace1 influences zebrafish cardiac development via ROS-dependent mechanisms. Dev Dyn. 2017 Oct 11. doi: 10.1002/dvdy.24600. [Epub ahead of print]. |
An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes
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Citation:
RSC Adv. 2017;7:42519-42528. doi: 10.1039/C7RA04247G. Epub 2017 Sep 4 Epub:
Not Epub Abstract:
An efficient method for the delivery of uncharged polyA-tailed phosphorodiamidate morpholino sequences (PMO) in mammalian cells... Delivery Method:
complementary phosphorothioate oligo Organism or Cell Type:
cell culture: HeLa pLuc705, mdx myotubes Citation Extract: Jain HV, Boehler JF, Verthelyi D, Nagaraju K, Beaucage SL. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes. RSC Adv. 2017;7:42519-42528. doi: 10.1039/C7RA04247G. Epub 2017 Sep 4. |
Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of mesendoderm tissue at gastrulation
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Citation:
Development. 2017 Oct 5. pii: dev.155200. doi: 10.1242/dev.155200. [Epub ahead of print] Epub:
Yes Abstract:
Coordination of individual cell behaviors is a critical step in the assembly and morphogenesis of tissues. Xenopus mesendoderm... Organism or Cell Type:
Xenopus Citation Extract: Sonavane PR, Wang C, Dzamba B, Weber GF, Periasamy A, DeSimone DW. Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of mesendoderm tissue at gastrulation. Development. 2017 Oct 5. pii: dev.155200. doi: 10.1242/dev.155200. [Epub ahead of print]. |
A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning
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Citation:
Dev Biol. 2017 Oct 15;430(2):346-361. doi: 10.1016/j.ydbio.2017.08.015. Epub 2017 Aug 14 Epub:
Not Epub Abstract:
Germ layer formation and axial patterning are biological processes that are tightly linked during embryonic development of most... Organism or Cell Type:
Nematostella vectensis (sea anemone) Citation Extract: Amiel AR, Johnston H, Chock T, Dahlin P, Iglesias M, Layden M, Röttinger E, Martindale MQ. A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning. Dev Biol. 2017 Oct 15;430(2):346-361. doi: 10.1016/j.ydbio.2017.08.015. Epub 2017 Aug 14. |
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
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Citation:
Lancet. 2011 Aug 13;378(9791):595-605. doi: 10.1016/S0140-6736(11)60756-3. Epub 2011 Jul 23 Epub:
Not Epub Abstract:
BACKGROUND: We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. Lancet. 2011 Aug 13;378(9791):595-605. doi: 10.1016/S0140-6736(11)60756-3. Epub 2011 Jul 23. |
Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
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Citation:
Nat Comm. 2017;8:769. doi:10.1038/s41467-017-00666-6 Epub:
Not Epub Abstract:
Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng X-XI, Groff M, Kasper Wang K, Parsons MJ, Crump JG, Dong PDS. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Comm. 2017;8:769. doi:10.1038/s41467-017-00666-6. |
U1 snRNP telescripting regulates a size-function-stratified human genome
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Citation:
Nat Struct Mol Biol. 2017 Oct 2. doi: 10.1038/nsmb.3473. [Epub ahead of print] Epub:
Yes Abstract:
U1 snRNP (U1) functions in splicing introns and telescripting, which suppresses premature cleavage and polyadenylation (PCPA).... Organism or Cell Type:
cell culture: HeLa Citation Extract: Oh JM, Di C, Venters CC, Guo J, Arai C, So BR, Pinto AM, Zhang Z, Wan L, Younis I, Dreyfuss G. U1 snRNP telescripting regulates a size-function-stratified human genome. Nat Struct Mol Biol. 2017 Oct 2. doi: 10.1038/nsmb.3473. [Epub ahead of print]. |
Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice
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Citation:
J Drug Target. 2017 Oct 3:1-34. doi: 10.1080/1061186X.2017.1387789. [Epub ahead of print] Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a class of antisense oligonucleotides used in the treatment of... Delivery Method:
i.v. injection Organism or Cell Type:
mice Citation Extract: Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. J Drug Target. 2017 Oct 3:1-34. doi: 10.1080/1061186X.2017.1387789. [Epub ahead of print]. |