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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease

Authors:
Hu Z-y, Chen B, Zhang J-p, Ma Y-y
Citation:
J Biol Chem. 2017;292:18062-74. doi:10.1074/jbc.M116.764795
Epub:
Not Epub
Abstract:
Parkinson's disease (PD) is one of the most epidemic neurodegenerative diseases and is characterized by movement disorders...
Link:
http://www.jbc.org/content/292/44/18062.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hu Z-y, Chen B, Zhang J-p, Ma Y-y. Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease. J Biol Chem. 2017;292:18062-74. doi:10.1074/jbc.M116.764795.

Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations

Authors:
Sanna-Cherchi S, Khan K, Westland R, Krithivasan P, Fievet L, Rasouly HM, Ionita-Laza I, Capone VP, Fasel DA, Kiryluk K, Kamalakaran S, Bodria M, Otto EA, Sampson G, Gillies CE, Vega-Warner V, Vukojevic K, Pediaditakis I, Makar GS, Mitrotti A, Verbitsky M, Martino J, Liu Q, Na Y-J, Goj V, Ardissino G, Gigante M, Gesualdo L, Janezcko M, Zaniew M, Mendelsohn CL, Shril S, Hildebrandt F, van Wijk JAE, Arapovic A, Saraga M, Allegri L, Izzi C, Scolari F, Tasic V, Ghiggeri GM, Latos-Bielenska A, Kiryluk A-M, Mane S, Goldstein DB, Lifton RP, Katsanis N, Davis EE, Gharavi AG
Citation:
Am J Hum Genet. 2017;101(5):789-802. doi:10.1016/j.ajhg.2017.09.018
Epub:
Not Epub
Abstract:
Renal agenesis and hypodysplasia (RHD) are major causes of pediatric chronic kidney disease and are highly genetically...
Link:
http://www.cell.com/ajhg/fulltext/S0002-9297(17)30387-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanna-Cherchi S, Khan K, Westland R, Krithivasan P, Fievet L, Rasouly HM, Ionita-Laza I, Capone VP, Fasel DA, Kiryluk K, Kamalakaran S, Bodria M, Otto EA, Sampson G, Gillies CE, Vega-Warner V, Vukojevic K, Pediaditakis I, Makar GS, Mitrotti A, Verbitsky M, Martino J, Liu Q, Na Y-J, Goj V, Ardissino G, Gigante M, Gesualdo L, Janezcko M, Zaniew M, Mendelsohn CL, Shril S, Hildebrandt F, van Wijk JAE, Arapovic A, Saraga M, Allegri L, Izzi C, Scolari F, Tasic V, Ghiggeri GM, Latos-Bielenska A, Kiryluk A-M, Mane S, Goldstein DB, Lifton RP, Katsanis N, Davis EE, Gharavi AG. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Am J Hum Genet. 2017;101(5):789-802. doi:10.1016/j.ajhg.2017.09.018.

Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development

Authors:
St Clair RM, Emerson SE, D'Elia KP, Weir ME, Schmoker AM, Ebert AM, Ballif BA
Citation:
FEBS J. 2017 Nov 1. doi: 10.1111/febs.14313. [Epub ahead of print]
Epub:
Yes
Abstract:
Plexins (Plxns) are semaphorin (Sema) receptors that play important signaling roles, particularly in the developing nervous...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/febs.14313/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
St Clair RM, Emerson SE, D'Elia KP, Weir ME, Schmoker AM, Ebert AM, Ballif BA. Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development. FEBS J. 2017 Nov 1. doi: 10.1111/febs.14313. [Epub ahead of print].

Znf703, a novel target of Pax3 and Zic1, regulates hindbrain and neural crest development in Xenopus

Authors:
Hong CS, Saint-Jeannet JP
Citation:
Genesis. 2017 Oct 31. doi: 10.1002/dvg.23082. [Epub ahead of print]
Epub:
Yes
Abstract:
The transcription factors Pax3 and Zic1 are critical to specify the neural plate border and to promote neural crest formation....
Link:
http://onlinelibrary.wiley.com/doi/10.1002/dvg.23082/abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Hong CS, Saint-Jeannet JP. Znf703, a novel target of Pax3 and Zic1, regulates hindbrain and neural crest development in Xenopus. Genesis. 2017 Oct 31. doi: 10.1002/dvg.23082. [Epub ahead of print].

Cohesin mediates Esco2-dependent transcriptional regulation in zebrafish regenerating fin model of Roberts syndrome

Authors:
Banerji R, Skibbens RV, Iovine MK
Citation:
Biol Open. 2017 Oct 30. pii: bio.026013. doi: 10.1242/bio.026013. [Epub ahead of print]
Epub:
Yes
Abstract:
Robert syndrome (RBS) and Cornelia de Lange syndrome (CdLS) are human developmental disorders characterized by craniofacial...
Link:
http://bio.biologists.org/content/early/2017/10/27/bio.026013.long
Delivery Method:
microinjection, electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Banerji R, Skibbens RV, Iovine MK. Cohesin mediates Esco2-dependent transcriptional regulation in zebrafish regenerating fin model of Roberts syndrome. Biol Open. 2017 Oct 30. pii: bio.026013. doi: 10.1242/bio.026013. [Epub ahead of print].

Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication

Authors:
Sindhwani A, Arya SB, Kaur H, Jagga D, Tuli A, Sharma M
Citation:
PLoS Pathog. 2017;13(10):e1006700. doi:10.1371/journal.ppat.1006700
Epub:
Not Epub
Abstract:
Salmonella enterica serovar typhimurium extensively remodels the host late endocytic compartments to establish its vacuolar...
Link:
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006700
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Sindhwani A, Arya SB, Kaur H, Jagga D, Tuli A, Sharma M. Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication. PLoS Pathog. 2017;13(10):e1006700. doi:10.1371/journal.ppat.1006700.

Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

Authors:
Liu JA, Rao Y, Cheung MPL, Hui M-N, Wu M-H, Chan L-K, Ng IO-L, Niu B, Cheah KSE, Sharma R, Hodgson L, Cheung M
Citation:
Nat Comm. 2017;8:1185. doi:10.1038/s41467-017-01107-0
Epub:
Not Epub
Abstract:
Following epithelial-mesenchymal transition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for...
Link:
https://www.nature.com/articles/s41467-017-01107-0
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Liu JA, Rao Y, Cheung MPL, Hui M-N, Wu M-H, Chan L-K, Ng IO-L, Niu B, Cheah KSE, Sharma R, Hodgson L, Cheung M. Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration. Nat Comm. 2017;8:1185. doi:10.1038/s41467-017-01107-0.

A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling

Authors:
Vedula V, Lee J, Xu H, Kuo C-CJ, Hsiai TK, Marsden AL
Citation:
PLoS Comput Biol. 2017;13(10):e1005828. doi:journal.pcbi.1005828
Epub:
Not Epub
Abstract:
Blood flow and mechanical forces in the ventricle are implicated in cardiac development and trabeculation. However, the...
Link:
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005828
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vedula V, Lee J, Xu H, Kuo C-CJ, Hsiai TK, Marsden AL. A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling. PLoS Comput Biol. 2017;13(10):e1005828. doi:journal.pcbi.1005828.

Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality

Authors:
Qiu D, Hou X, Han L, Li X, Ge J, Wang Q
Citation:
Aging Cell. 2017 Oct 25. doi: 10.1111/acel.12698. [Epub ahead of print]
Epub:
Yes
Abstract:
The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/acel.12698/full
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Qiu D, Hou X, Han L, Li X, Ge J, Wang Q. Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality. Aging Cell. 2017 Oct 25. doi: 10.1111/acel.12698. [Epub ahead of print].

PMO Delivery System Using Bubble Liposomes and Ultrasound Exposure for Duchenne Muscular Dystrophy Treatment

Authors:
Negishi Y, Ishii Y, Nirasawa K, Sasaki E, Endo-Takahashi Y, Suzuki R, Maruyama K
Citation:
Methods Mol Biol. 2018;1687:185-192. doi: 10.1007/978-1-4939-7374-3_13
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration, caused by nonsense or...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-7374-3_13
Delivery Method:
bubble liposome & ultrasound
Organism or Cell Type:
mice
Citation Extract:
Negishi Y, Ishii Y, Nirasawa K, Sasaki E, Endo-Takahashi Y, Suzuki R, Maruyama K. PMO Delivery System Using Bubble Liposomes and Ultrasound Exposure for Duchenne Muscular Dystrophy Treatment. Methods Mol Biol. 2018;1687:185-192. doi: 10.1007/978-1-4939-7374-3_13.

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