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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis

Authors:
Vignes H, Vagena-Pantoula C, Prakash M, Fukui H, Norden C, Mochizuki N, Jug F, Vermot J
Citation:
Dev Cell. 2022 Feb 28:S1534-5807(22)00077-6. doi:10.1016/j.devcel.2022.02.011. Online ahead of print
Epub:
Yes
Abstract:
Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to their mechanical environment through...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580722001034
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vignes H, Vagena-Pantoula C, Prakash M, Fukui H, Norden C, Mochizuki N, Jug F, Vermot J. Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Dev Cell. 2022 Feb 28:S1534-5807(22)00077-6. doi:10.1016/j.devcel.2022.02.011. Online ahead of print.

Targeted exon skipping of NF1 exon 17 as a Therapeutic for Neurofibromatosis Type I

Authors:
Leier A, Moore M, Liu H, Daniel M, Hyde AM, Messiaen L, Korf BR, Selvakumaran J, Ciszewski L, Lambert L, Foote J, Wallace MR, Kesterson RA, Dickson G, Popplewell L, Wallis D
Citation:
Mol Ther Nucleic Acids. 2022;[Epub] doi:10.1016/j.omtn.2022.03.011
Epub:
Not Epub
Abstract:
We investigated the feasibility of utilizing an exon skipping approach as a genotype-dependent therapeutic for...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00060-9
Delivery Method:
Endo-Porter DMSO
Organism or Cell Type:
cell culture: human lines with NF1 e17 mutations
Citation Extract:
Leier A, Moore M, Liu H, Daniel M, Hyde AM, Messiaen L, Korf BR, Selvakumaran J, Ciszewski L, Lambert L, Foote J, Wallace MR, Kesterson RA, Dickson G, Popplewell L, Wallis D. Targeted exon skipping of NF1 exon 17 as a Therapeutic for Neurofibromatosis Type I. Mol Ther Nucleic Acids. 2022;[Epub] doi:10.1016/j.omtn.2022.03.011.

Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes

Authors:
Lv X, Zhang R, Xu L, Wang G, Yan C, Lin P
Citation:
Front Cell Dev Biol. 2022;10:836464. doi:10.3389/fcell.2022.836464
Epub:
Not Epub
Abstract:
Limb-girdle muscular dystrophy 2G (LGMD2G) is a subtype of limb-girdle muscular dystrophy. However, the disease’s mechanisms...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2022.836464/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv X, Zhang R, Xu L, Wang G, Yan C, Lin P. Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes. Front Cell Dev Biol. 2022;10:836464. doi:10.3389/fcell.2022.836464.

Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly

Authors:
Gur M, Bendelac-Kapon L, Shabtai Y, Pillemer G, Fainsod A
Citation:
Front Cell Dev Biol. 2022;10:844619. doi:10.3389/fcell.2022.844619
Epub:
Not Epub
Abstract:
Retinoic acid (RA) is a central signaling molecule regulating multiple developmental decisions during embryogenesis. Excess RA...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2022.844619/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gur M, Bendelac-Kapon L, Shabtai Y, Pillemer G, Fainsod A. Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly. Front Cell Dev Biol. 2022;10:844619. doi:10.3389/fcell.2022.844619.

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Authors:
Laghi V, Rezelj V, Boucontet L, Frétaud M, Da Costa B, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud J-P
Citation:
Front Cell Infect Microbiol. 2022;12:790851. doi:10.3389/fcimb.2022.790851
Epub:
Not Epub
Abstract:
Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other...
Link:
https://www.frontiersin.org/articles/10.3389/fcimb.2022.790851/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Laghi V, Rezelj V, Boucontet L, Frétaud M, Da Costa B, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud J-P. Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder. Front Cell Infect Microbiol. 2022;12:790851. doi:10.3389/fcimb.2022.790851.

The Ribosomal Protein L5 Functions During Xenopus Anterior Development Through Apoptotic Pathways

Authors:
Schreiner C, Kernl B, Dietmann P, Riegger RJ, Kühl M, Kühl SJ
Citation:
Front Cell Dev Biol. 2022 Feb 22;10:777121. doi: 10.3389/fcell.2022.777121. eCollection 2022
Epub:
Not Epub
Abstract:
Ribosomal biogenesis is a fundamental process necessary for cell growth and division. Ribosomal protein L5 (Rpl5) is part of...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2022.777121/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schreiner C, Kernl B, Dietmann P, Riegger RJ, Kühl M, Kühl SJ. The Ribosomal Protein L5 Functions During Xenopus Anterior Development Through Apoptotic Pathways. Front Cell Dev Biol. 2022 Feb 22;10:777121. doi: 10.3389/fcell.2022.777121. eCollection 2022.

d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona

Authors:
Krasovec G, Hozumi A, Yoshida T, Obita T, Hamada M, Shiraishi A, Satake H, Horie T, Mori H, Sasakura Y
Citation:
Sci Adv. 2022;8(10):eabn3264. doi:10.1126/sciadv.abn3264
Epub:
Not Epub
Abstract:
d-Serine, a free amino acid synthesized by serine racemase, is a coagonist of N-methyl-d-aspartate–type glutamate receptor (...
Link:
https://www.science.org/doi/10.1126/sciadv.abn3264
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Krasovec G, Hozumi A, Yoshida T, Obita T, Hamada M, Shiraishi A, Satake H, Horie T, Mori H, Sasakura Y. d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona. Sci Adv. 2022;8(10):eabn3264. doi:10.1126/sciadv.abn3264.

Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis

Authors:
Shan M-M, Zou Y-J, Pan Z-N, Zhang H-L, Xu Y, Ju J-Q, Sun S-C
Citation:
Development. 2022;149(5):dev200231. doi:10.1242/dev.200231
Epub:
Not Epub
Abstract:
Mammalian oocyte maturation is a unique asymmetric division, which is mainly because of actin-based spindle migration to the...
Link:
https://journals.biologists.com/dev/article-abstract/149/5/dev200231/274694/Kinesin-motor-KIFC1-is-required-for-tubulin
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Shan M-M, Zou Y-J, Pan Z-N, Zhang H-L, Xu Y, Ju J-Q, Sun S-C. Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis. Development. 2022;149(5):dev200231. doi:10.1242/dev.200231.

Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms

Authors:
Pan S, Cesarek M, Godoy C, Co CM, Schindler C, Padilla K, Haskell A, Barreda H, Story C, Poole R, Dabney A, Gregory CA
Citation:
Br J Cancer. 2022 Jul;127(1):43-55. doi: 10.1038/s41416-022-01764-z. Epub 2022 Mar 11
Epub:
Not Epub
Abstract:
Background: Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment...
Link:
https://www.nature.com/articles/s41416-022-01764-z
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: (RFP)-labeled MOSJ-Dkk1 murine osteochondral sarcoma line, xenograft in Foxn1-/Foxn1- mice
Citation Extract:
Pan S, Cesarek M, Godoy C, Co CM, Schindler C, Padilla K, Haskell A, Barreda H, Story C, Poole R, Dabney A, Gregory CA. Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms. Br J Cancer. 2022 Jul;127(1):43-55. doi: 10.1038/s41416-022-01764-z. Epub 2022 Mar 11.

Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis

Authors:
Schultz-Rogers LE, Thayer ML, Kambakam S, Wierson WA, Helmer JA, Wishman MD, Wall KA, Greig JL, Forsman JL, Puchhalapalli K, Nair S, Weiss TJ, Luiken JM, Blackburn PR, Ekker SC, Kool M, McGrail M
Citation:
Dev Dyn. 2022 Mar 9. doi: 10.1002/dvdy.467. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Retinoblastoma-binding protein 4 (Rbbp4) is a component of transcription regulatory complexes that control cell...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.467
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schultz-Rogers LE, Thayer ML, Kambakam S, Wierson WA, Helmer JA, Wishman MD, Wall KA, Greig JL, Forsman JL, Puchhalapalli K, Nair S, Weiss TJ, Luiken JM, Blackburn PR, Ekker SC, Kool M, McGrail M. Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis. Dev Dyn. 2022 Mar 9. doi: 10.1002/dvdy.467. Online ahead of print.

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