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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12511 scientific papers returned from the database with the search filters currently being used below.

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential

Authors:
Malka Y, Alkan F, Ju S, Körner P-R, Pataskar A, Shulman E, Loayza-Puch F, Champagne J, Wenzel C, Faller WJ, Elkon R, Lee C, Agami R
Citation:
Molec Cell. 2022;82(20):3840-3855.e8. doi:10.1016/j.molcel.2022.09.036
Epub:
Not Epub
Abstract:
The use of alternative promoters, splicing, and cleavage and polyadenylation (APA) generates mRNA isoforms that expand the...
Link:
https://www.sciencedirect.com/science/article/pii/S1097276522009571
Delivery Method:
transfection
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Malka Y, Alkan F, Ju S, Körner P-R, Pataskar A, Shulman E, Loayza-Puch F, Champagne J, Wenzel C, Faller WJ, Elkon R, Lee C, Agami R. Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential. Molec Cell. 2022;82(20):3840-3855.e8. doi:10.1016/j.molcel.2022.09.036.

Patterning of phase-separated condensates by Dnd1 controls cell fate

Authors:
Westerich KJ, Tarbashevich K, Gupta A, Zhu M, Hull K, Daniel Romo, Gross-Thebing T, Raz E
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.20.512863
Epub:
Not Epub
Abstract:
Germ granules, condensates of phase-separated RNA and protein, are essential for germline development, but how these molecules...
Link:
https://www.biorxiv.org/content/10.1101/2022.10.20.512863v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Westerich KJ, Tarbashevich K, Gupta A, Zhu M, Hull K, Daniel Romo, Gross-Thebing T, Raz E. Patterning of phase-separated condensates by Dnd1 controls cell fate. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.20.512863 .

Alternative splicing of apoptosis genes promotes human T cell survival

Authors:
Blake D, Radens CM, Ferretti MB, Gazzara MR, Lynch KW
Citation:
eLife. 2022;11:e80953. doi:10.7554/eLife.80953
Epub:
Not Epub
Abstract:
Alternative splicing occurs in the vast majority of human genes, giving rise to distinct mRNA and protein isoforms. We, and...
Link:
https://elifesciences.org/articles/80953
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: Jurkat
Citation Extract:
Blake D, Radens CM, Ferretti MB, Gazzara MR, Lynch KW. Alternative splicing of apoptosis genes promotes human T cell survival. eLife. 2022;11:e80953. doi:10.7554/eLife.80953.

Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm

Authors:
Matsuda M, Chu CW, Sokol SY
Citation:
Development. 2022 May 15;149(10):dev200236. doi: 10.1242/dev.200236. Epub 2022 May 16
Epub:
Not Epub
Abstract:
Apical constriction, or a reduction in size of the apical domain, underlies many morphogenetic events during development....
Link:
https://journals.biologists.com/dev/article-abstract/149/10/dev200236/275389/Lmo7-recruits-myosin-II-heavy-chain-to-regulate
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Matsuda M, Chu CW, Sokol SY. Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm. Development. 2022 May 15;149(10):dev200236. doi: 10.1242/dev.200236. Epub 2022 May 16.

Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models

Authors:
Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor K, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC
Citation:
J Bone Miner Res. 2022 Sep 25. doi: 10.1002/jbmr.4711. Online ahead of print
Epub:
Not Epub
Abstract:
Bone morphogenetic protein (BMP) signaling is critical in skeletal development. Over-activation can trigger heterotopic...
Link:
https://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbmr.4711
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor K, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC. Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models. J Bone Miner Res. 2022 Sep 25. doi: 10.1002/jbmr.4711. Online ahead of print.

Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona

Authors:
Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard B, Oka K, Heisenberg C-P, Hotta K
Citation:
Development. 2022;149(21):dev200215. doi:10.1242/dev.200215
Epub:
Not Epub
Abstract:
Ventral tail bending, which is transient but pronounced, is found in many chordate embryos and constitutes an interesting model...
Link:
https://journals.biologists.com/dev/article/149/21/dev200215/278081/Admp-regulates-tail-bending-by-controlling-ventral
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (ascidian)
Citation Extract:
Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard B, Oka K, Heisenberg C-P, Hotta K. Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona. Development. 2022;149(21):dev200215. doi:10.1242/dev.200215.

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart

Authors:
Müller M, Eghbalian R, Boeckel J-N, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins BD, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B
Citation:
Nat Commun. 2022;13:6209. doi:10.1038/s41467-022-33658-2
Epub:
Not Epub
Abstract:
To adapt to changing hemodynamic demands, regulatory mechanisms modulate actin-myosin-kinetics by calcium-dependent and -...
Link:
https://www.nature.com/articles/s41467-022-33658-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Müller M, Eghbalian R, Boeckel J-N, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins BD, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B. NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nat Commun. 2022;13:6209. doi:10.1038/s41467-022-33658-2.

Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins

Authors:
Davidson PL, Guo H, Swart JS, Massri AJ, Edgar A, Wang L, Berrio A, Devens HR, Koop D, Cisternas P, Zhang H, Zhang Y, Byrne M, Fan G, Wray GA
Citation:
Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01906-9
Epub:
Not Epub
Abstract:
Changes in developmental gene regulatory networks (dGRNs) underlie much of the diversity of life, but the evolutionary...
Link:
https://www.nature.com/articles/s41559-022-01906-9
Delivery Method:
microinjection
Organism or Cell Type:
Heliocidaris erythrogramma (sea urchin)
Citation Extract:
Davidson PL, Guo H, Swart JS, Massri AJ, Edgar A, Wang L, Berrio A, Devens HR, Koop D, Cisternas P, Zhang H, Zhang Y, Byrne M, Fan G, Wray GA. Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins. Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01906-9.

Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells

Authors:
Zhang R, Tu YX, Ye D, Gu Z, Chen ZX, Sun Y
Citation:
Adv Sci (Weinh). 2022 Oct 18:e2203631. doi: 10.1002/advs.202203631. Online ahead of print
Epub:
Not Epub
Abstract:
Maintenance and differentiation of germline stem and progenitor cells (GSPCs) is important for sexual reproduction. Here, the...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202203631
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang R, Tu YX, Ye D, Gu Z, Chen ZX, Sun Y. Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Adv Sci (Weinh). 2022 Oct 18:e2203631. doi: 10.1002/advs.202203631. Online ahead of print.

5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

Authors:
Zhang Y, Zhang L-S, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J
Citation:
Proc Nat Acad Sci USA. 2022;119(42):e2123338119 doi:10.1073/pnas.2123338119
Epub:
Not Epub
Abstract:
5-methylcytosine (m5C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear...
Link:
https://www.pnas.org/doi/abs/10.1073/pnas.2123338119
Delivery Method:
Vivo-Morpholino intranasal & i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Zhang Y, Zhang L-S, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J. 5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons. Proc Nat Acad Sci USA. 2022;119(42):e2123338119 doi:10.1073/pnas.2123338119.

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