You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway

Authors:
de Sousa E, Móvio MI, de Lima-Vasconcellos TH, Dos Santos GB, Dos Santos Gomes T, Walter LT, da Silva DA, Rodrigues T, Cerchiaro G, Kihara AH
Citation:
Cell Death Dis. 2022 Apr 21;13(4):393. doi: 10.1038/s41419-022-04755-3
Epub:
Not Epub
Abstract:
The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of...
Link:
https://www.nature.com/articles/s41419-022-04755-3
Delivery Method:
subretinal injection
Organism or Cell Type:
male and female Long Evans rats (Rattus norvegicus)
Citation Extract:
de Sousa E, Móvio MI, de Lima-Vasconcellos TH, Dos Santos GB, Dos Santos Gomes T, Walter LT, da Silva DA, Rodrigues T, Cerchiaro G, Kihara AH. VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway. Cell Death Dis. 2022 Apr 21;13(4):393. doi: 10.1038/s41419-022-04755-3.

The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

Authors:
Holm A, Possovre M-L, Bandarabadi M, Moseholm KF, Justinussen JL, Bozic I, Lemcke R, Arribat Y, Amati F, Silahtaroglu A, Juventin M, Adamantidis A, Tafti M, Kornum BR
Citation:
Proc Nat Acad Sci USA. 2022;117(17):e2112225119 [Epub] doi:10.1073/pnas.2112225119
Epub:
Not Epub
Abstract:
Hypocretin (Hcrt), also known as orexin, neuropeptide signaling stabilizes sleep and wakefulness in all vertebrates. A lack of...
Link:
https://www.pnas.org/doi/10.1073/pnas.2112225119
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Holm A, Possovre M-L, Bandarabadi M, Moseholm KF, Justinussen JL, Bozic I, Lemcke R, Arribat Y, Amati F, Silahtaroglu A, Juventin M, Adamantidis A, Tafti M, Kornum BR. The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio. Proc Nat Acad Sci USA. 2022;117(17):e2112225119 [Epub] doi:10.1073/pnas.2112225119.

Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders

Authors:
Jeong HS, Kim HJ, Kim D-H, Chung KW, Choi B-O, Lee JE
Citation:
Mol Cells. 2022;45(4):231-42. doi:10.14348/molcells.2022.5005
Epub:
Not Epub
Abstract:
The neuromuscular junction (NMJ), which is a synapse for signal transmission from motor neurons to muscle cells, has emerged as...
Link:
https://www.molcells.org/journal/view.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jeong HS, Kim HJ, Kim D-H, Chung KW, Choi B-O, Lee JE. Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders. Mol Cells. 2022;45(4):231-42. doi:10.14348/molcells.2022.5005.

Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions

Authors:
Fernandez-Nicolas A, Uchida A, Poon J, Yajima M
Citation:
Nat Commun. 2022 Apr 20;13(1):2145. doi: 10.1038/s41467-022-29855-8
Epub:
Not Epub
Abstract:
mRNA translation on the spindle is hypothesized to be an essential strategy for the localized production of cell regulators....
Link:
https://www.nature.com/articles/s41467-022-29855-8
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Fernandez-Nicolas A, Uchida A, Poon J, Yajima M. Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions. Nat Commun. 2022 Apr 20;13(1):2145. doi: 10.1038/s41467-022-29855-8.

Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis

Authors:
Tournière O, Gahan JM, Busengdal H, Bartsch N, Rentzsch F
Citation:
Sci Adv. 2022 Apr 22;8(16):eabi7109. doi:10.1126/sciadv.abi7109. Epub 2022 Apr 20
Epub:
Not Epub
Abstract:
Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other...
Link:
https://www.science.org/doi/10.1126/sciadv.abi7109
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Tournière O, Gahan JM, Busengdal H, Bartsch N, Rentzsch F. Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis. Sci Adv. 2022 Apr 22;8(16):eabi7109. doi:10.1126/sciadv.abi7109. Epub 2022 Apr 20.

A posttranscriptional mechanism that controls Ptbp1 abundance in the Xenopus epidermis

Authors:
Méreau A, Anquetil V, Lerivray H, Viet J, Schirmer C, Audic Y, Legagneux V, Hardy S, Paillard L
Citation:
Mol Cell Biol. 2015 Feb;35(4):758-68. doi: 10.1128/MCB.01040-14. Epub 2014 Dec 15
Epub:
Not Epub
Abstract:
The output of alternative splicing depends on the cooperative or antagonistic activities of several RNA-binding proteins (RBPs...
Link:
https://journals.asm.org/doi/10.1128/MCB.01040-14
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Méreau A, Anquetil V, Lerivray H, Viet J, Schirmer C, Audic Y, Legagneux V, Hardy S, Paillard L. A posttranscriptional mechanism that controls Ptbp1 abundance in the Xenopus epidermis. Mol Cell Biol. 2015 Feb;35(4):758-68. doi: 10.1128/MCB.01040-14. Epub 2014 Dec 15.

Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development

Authors:
Brooks KE, Daughtry BL, Davis B, Yan MY, Fei SS, Shepherd S, Carbone L, Chavez SL
Citation:
Development. 2022 Apr 1;149(7):dev198341. doi: 10.1242/dev.198341. Epub 2022 Apr 14
Epub:
Not Epub
Abstract:
Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation failure or spontaneous miscarriage...
Link:
https://journals.biologists.com/dev/article-abstract/149/7/dev198341/275037/Molecular-contribution-to-embryonic-aneuploidy-and
Delivery Method:
Endo-Porter (cultures), microinjection (zygotes)
Organism or Cell Type:
cell culture: Madin-Darby Bovine Kidney (MDBK), bovine (Bos taurus) zygotes 20hpf
Citation Extract:
Brooks KE, Daughtry BL, Davis B, Yan MY, Fei SS, Shepherd S, Carbone L, Chavez SL. Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development. Development. 2022 Apr 1;149(7):dev198341. doi: 10.1242/dev.198341. Epub 2022 Apr 14.

VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion

Authors:
Dong X, Jiang D, Wang L, Zhao J, Yu L, Huang Y, Wu X, Zhu Y, Zhao Y, Zhao Q, Zhang G, Li X
Citation:
iScience. 2022 Mar 9;25(4):104042. doi: 10.1016/j.isci.2022.104042. eCollection 2022 Apr 15
Epub:
Not Epub
Abstract:
Extracellular vesicles (EVs) participate in intercellular communication and contribute to the angiogenesis. However, the...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004222003121
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dong X, Jiang D, Wang L, Zhao J, Yu L, Huang Y, Wu X, Zhu Y, Zhao Y, Zhao Q, Zhang G, Li X. VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion. iScience. 2022 Mar 9;25(4):104042. doi: 10.1016/j.isci.2022.104042. eCollection 2022 Apr 15.

In-Cell Penetration Selection-Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery

Authors:
Schissel CK, Farquhar CE, Loas A, Malmberg AB, Pentelute BL
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.04.13.488231
Epub:
Not Epub
Abstract:
Peptide-mediated delivery of macromolecules in cells has significant potential therapeutic benefits, but no therapy employing...
Link:
https://www.biorxiv.org/content/10.1101/2022.04.13.488231v1.full
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa 654
Citation Extract:
Schissel CK, Farquhar CE, Loas A, Malmberg AB, Pentelute BL. In-Cell Penetration Selection-Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery. bioRxiv. 2022;[preprint] doi:10.1101/2022.04.13.488231.

Synthesis of Morpholino Nucleosides Starting From Enantiopure Glycidol

Authors:
Papis M, Loro C, Penso M, Broggini G, Foschi F
Citation:
Org Chem Front. 2022;[Epub] doi:10.1039/D2QO00400C
Epub:
Yes
Abstract:
A protocol for the synthesis of modified morpholino monomers was performed in few steps through the condensation between 6-...
Link:
https://pubs.rsc.org/en/Content/ArticleLanding/2022/QO/D2QO00400C
Citation Extract:
Papis M, Loro C, Penso M, Broggini G, Foschi F. Synthesis of Morpholino Nucleosides Starting From Enantiopure Glycidol. Org Chem Front. 2022;[Epub] doi:10.1039/D2QO00400C.

Pages