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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
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Citation:
Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print Epub:
Yes Abstract:
RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors show... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
xenograft in mice Citation Extract: Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA. Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers. Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print. |
Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish
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Citation:
Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print Epub:
Yes Abstract:
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print. |
The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1
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Citation:
Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print Epub:
Yes Abstract:
Background: Spermatogonial stem cells (SSCs) are unique stem cells that account for the whole reproductive life of males and... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
murine explants Citation Extract: Zhou H, Shen C, Guo Y, Huang X, Zheng B, Wu Y. The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1. Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print. |
Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.26.482108 Epub:
Not Epub Abstract:
Maternally derived thyroid hormone (MT3) is a fundamental factor for vertebrate neurodevelopment. In humans, mutations on the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Silva N, Campinho MA. Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.26.482108. |
Zebrafish her3 knockout impacts developmental and cancer-related gene signatures
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.25.482038 Epub:
Not Epub Abstract:
HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kent MR, Calderon D, Silvius KM, LaVigne CA, Cannon MV, Kendall GC. Zebrafish her3 knockout impacts developmental and cancer-related gene signatures. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.25.482038. |
Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells
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Citation:
bioRxiv. 2022;[preprint] doi:doi.org/10.1101/2022.02.22.481529 Epub:
Not Epub Abstract:
The interleukin 7 receptor (IL7R) is strongly associated with increased risk to develop multiple sclerosis (MS), an autoimmune... Delivery Method:
Endo-Porter PEG (HeLa), electroporation (primary CD4+ T) Organism or Cell Type:
cell culture: HeLa, human primary CD4+ T cells Citation Extract: Galarza-Muñoz G, Kennedy-Boone D, Schott G, Bradrick SS, Garcia-Blanco MA. Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells. bioRxiv. 2022;[preprint] doi:doi.org/10.1101/2022.02.22.481529. |
Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery
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Citation:
EMBO Rep. 2022 Feb 24:e52775. doi: 10.15252/embr.202152775. Online ahead of print Epub:
Not Epub Abstract:
Motile cilia on the cell surface generate movement and directional fluid flow that is crucial for various biological processes... Delivery Method:
microinjection Organism or Cell Type:
Xenopus, zebrafish Citation Extract: Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K, Stauffer J, Andresson T, Specht S, Perera S, Daar IO, Westlake CJ. Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery. EMBO Rep. 2022 Feb 24:e52775. doi: 10.15252/embr.202152775. Online ahead of print. |
SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal
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Citation:
Dev Cell. 2022 Feb 22:S1534-5807(22)00036-3. doi: 10.1016/j.devcel.2022.01.011. Online ahead of print Epub:
Not Epub Abstract:
Alternative splicing generates distinct mRNA variants and is essential for development, homeostasis, and renewal. Proteins of... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: primary murine cells: dental epithelium, intestinal organoid crypt Citation Extract: Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD. SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal. Dev Cell. 2022 Feb 22:S1534-5807(22)00036-3. doi: 10.1016/j.devcel.2022.01.011. Online ahead of print. |
A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis
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Citation:
Sci Adv. 2022 Feb 25;8(8):eabk3088. doi: 10.1126/sciadv.abk3088. Epub 2022 Feb 23 Epub:
Not Epub Abstract:
Primary cilia are sensory antennae crucial for cell and organism development, and defects in their biogenesis cause... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kumar R, Francis V, Kulasekaran G, Khan M, Armstrong GAB, McPherson PS. A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis. Sci Adv. 2022 Feb 25;8(8):eabk3088. doi: 10.1126/sciadv.abk3088. Epub 2022 Feb 23. |
Identification and establishment of type IV interferon and the characterization of interferon-upsilon including its class II cytokine receptors IFN-upsilonR1 and IL-10R2
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Citation:
Nat Commun. 2022 Feb 22;13(1):999. doi: 10.1038/s41467-022-28645-6 Epub:
Not Epub Abstract:
Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen SN, Gan Z, Hou J, Yang YC, Huang L, Huang B, Wang S, Nie P. Identification and establishment of type IV interferon and the characterization of interferon-upsilon including its class II cytokine receptors IFN-upsilonR1 and IL-10R2. Nat Commun. 2022 Feb 22;13(1):999. doi: 10.1038/s41467-022-28645-6. |