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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue

Authors:
Scripture-Adams DD, Chesmore KN, Barthélémy F, Wang RT, Nieves-Rodriguez S, Wang DW, Mokhonova EI, Douine ED, Wan J, Little I, Rabichow LN, Nelson SF, Miceli MC
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.31.494197
Epub:
Not Epub
Abstract:
In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty...
Link:
https://www.biorxiv.org/content/10.1101/2022.05.31.494197v1
Organism or Cell Type:
mice
Citation Extract:
Scripture-Adams DD, Chesmore KN, Barthélémy F, Wang RT, Nieves-Rodriguez S, Wang DW, Mokhonova EI, Douine ED, Wan J, Little I, Rabichow LN, Nelson SF, Miceli MC. Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.31.494197 .

Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater

Authors:
Ranasinghe N, Lin C-H, Lee T-H
Citation:
Front Mar Sci. 2022;9:{Epub] doi:10.3389/fmars.2022.891706
Epub:
Yes
Abstract:
Sterol regulatory-element binding proteins (SREBPs), sirtuin (SIRT1), and liver X receptor α (LXRα) play important roles in...
Link:
https://www.frontiersin.org/articles/10.3389/fmars.2022.891706/full
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Oryzias dancena (Indian medaka)
Citation Extract:
Ranasinghe N, Lin C-H, Lee T-H. Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater. Front Mar Sci. 2022;9:{Epub] doi:10.3389/fmars.2022.891706.

Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors

Authors:
Li R-F, Wang Y-S, Lu F-I, Huang Y-S, Chiu C-C, Tai M-H, Wu C-Y
Citation:
Biomedicines. 2022;10(6):1261. doi:/10.3390/biomedicines10061261
Epub:
Not Epub
Abstract:
The genetic regulation of vascular development is not elucidated completely. We previously characterized the transcription...
Link:
https://www.mdpi.com/2227-9059/10/6/1261
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li R-F, Wang Y-S, Lu F-I, Huang Y-S, Chiu C-C, Tai M-H, Wu C-Y. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 2022;10(6):1261. doi:/10.3390/biomedicines10061261.

A Strategy for Gene Knockdown in Dinoflagellates

Authors:
Judd M, Place AR
Citation:
Microorganisms. 2022;10:1131. doi:10.3390/microorganisms10061131
Epub:
Not Epub
Abstract:
Dinoflagellates are unicellular protists that display unusual nuclear features such as large genomes, condensed chromosomes and...
Link:
https://www.mdpi.com/2076-2607/10/6/1131
Delivery Method:
Endo-Porter
Organism or Cell Type:
Amphidinium carterae (dinoflagellate)
Citation Extract:
Judd M, Place AR. A Strategy for Gene Knockdown in Dinoflagellates. Microorganisms. 2022;10:1131. doi:10.3390/microorganisms10061131.

Dicer1 is required for pigment cell and craniofacial development in zebrafish

Authors:
Weiner AMJ, Scampoli NL, Steeman TJ, Dooley CM, Busch-Nentwich EM, Kelsh RN, Calcaterra NB
Citation:
Biochim Biophys Acta Gene Regul Mech. 2019 Apr;1862(4):472-485. doi: 10.1016/j.bbagrm.2019.02.005. Epub 2019 Mar 3
Epub:
Not Epub
Abstract:
The multidomain RNase III endoribonuclease DICER is required for the generation of most functional microRNAs (miRNAs). Loss of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1874939918305121
Organism or Cell Type:
zebrafish
Citation Extract:
Weiner AMJ, Scampoli NL, Steeman TJ, Dooley CM, Busch-Nentwich EM, Kelsh RN, Calcaterra NB. Dicer1 is required for pigment cell and craniofacial development in zebrafish. Biochim Biophys Acta Gene Regul Mech. 2019 Apr;1862(4):472-485. doi: 10.1016/j.bbagrm.2019.02.005. Epub 2019 Mar 3.

Adgrg6/Gpr126 is required for myocardial Notch activity and N-cadherin localization to attain trabecular identity

Authors:
Srivastava S, Gunawan F, Gentile A, Petersen SC, Stainier DYR, Engel FB
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.27.493401
Epub:
Not Epub
Abstract:
How adhesion G protein-coupled receptors (aGPCRs) control development remains unclear. The aGPCR Adgrg6/Gpr126 has been...
Link:
https://www.biorxiv.org/content/10.1101/2022.05.27.493401v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Srivastava S, Gunawan F, Gentile A, Petersen SC, Stainier DYR, Engel FB. Adgrg6/Gpr126 is required for myocardial Notch activity and N-cadherin localization to attain trabecular identity. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.27.493401.

Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery

Authors:
Zhang Y, Heylen L, Partoens M, Mills JD, Kaminski RM, Godard P, Gillard M, de Witte PAM, Siekierska A
Citation:
Front Mol Neurosci. 2022;15:[Epub] doi:10.3389/fnmol.2022.881933
Epub:
Yes
Abstract:
Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as...
Link:
https://www.frontiersin.org/articles/10.3389/fnmol.2022.881933/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Y, Heylen L, Partoens M, Mills JD, Kaminski RM, Godard P, Gillard M, de Witte PAM, Siekierska A. Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery. Front Mol Neurosci. 2022;15:[Epub] doi:10.3389/fnmol.2022.881933.

Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components

Authors:
Hantel F, Liu H, Fechtner L, Neuhaus H, Ding J, Arlt D, Walentek P, Villavicencio-Lorini P, Gerhardt C, Hollemann T, Pfirrmann T
Citation:
J Cell Sci. 2022 May 1;135(9):jcs259209. doi: 10.1242/jcs.259209. Epub 2022 May 11
Epub:
Not Epub
Abstract:
Cilia are evolutionarily conserved organelles that orchestrate a variety of signal transduction pathways, such as sonic...
Link:
https://journals.biologists.com/jcs/article/135/9/jcs259209/275349/Cilia-localized-GID-CTLH-ubiquitin-ligase-complex
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hantel F, Liu H, Fechtner L, Neuhaus H, Ding J, Arlt D, Walentek P, Villavicencio-Lorini P, Gerhardt C, Hollemann T, Pfirrmann T. Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components. J Cell Sci. 2022 May 1;135(9):jcs259209. doi: 10.1242/jcs.259209. Epub 2022 May 11.

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

Authors:
Lee AJ, Raghavan NS, Bhattarai P, Siddiqui T, Sariya S, Reyes-Dumeyer D, Flowers XE, Cardoso SAL, De Jager PL, Bennett DA, Schneider JA, Menon V, Wang Y, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Kukull WA, Brickman AM, Manly JJ, Tosto G, Kizil C, Vardarajan BN, Mayeux R
Citation:
Acta Neuropathol. 2022 May 24. doi: 10.1007/s00401-022-02431-6. Online ahead of print
Epub:
Not Epub
Abstract:
Alzheimer's disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle...
Link:
https://link.springer.com/article/10.1007/s00401-022-02431-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee AJ, Raghavan NS, Bhattarai P, Siddiqui T, Sariya S, Reyes-Dumeyer D, Flowers XE, Cardoso SAL, De Jager PL, Bennett DA, Schneider JA, Menon V, Wang Y, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Kukull WA, Brickman AM, Manly JJ, Tosto G, Kizil C, Vardarajan BN, Mayeux R. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease. Acta Neuropathol. 2022 May 24. doi: 10.1007/s00401-022-02431-6. Online ahead of print.

FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development

Authors:
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C
Citation:
Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5
Epub:
Not Epub
Abstract:
N6-methyladenosine (m6A) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer...
Link:
https://www.science.org/doi/10.1126/science.abe9582
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: mESC and Mel624
Citation Extract:
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5.

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