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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy

Authors:
De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Robert Liu W, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Martijn Bos J, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA
Citation:
Circ Genom Precis Med. 2022 Jun 7:101161CIRCGEN121003563. doi:10.1161/CIRCGEN.121.003563
Epub:
Yes
Abstract:
BACKGROUND: The study of hypertrophic cardiomyopathy (HCM) - a severe Mendelian disease - can yield insight into the mechanisms...
Link:
https://www.ahajournals.org/doi/10.1161/CIRCGEN.121.003563
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Robert Liu W, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Martijn Bos J, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA. Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circ Genom Precis Med. 2022 Jun 7:101161CIRCGEN121003563. doi:10.1161/CIRCGEN.121.003563.

Anti-cancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer

Authors:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Citation:
Research Square 2022:[preprint] doi:10.21203/rs.3.rs-1704679/v1
Epub:
Not Epub
Abstract:
Background: Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Colorectal cancer (CRC...
Link:
https://www.researchsquare.com/article/rs-1704679/v1
Delivery Method:
peptide-linked exosomal
Organism or Cell Type:
cell culture: CRC
Citation Extract:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X. Anti-cancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Research Square 2022:[preprint] doi:10.21203/rs.3.rs-1704679/v1.

Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

Authors:
Bouftas N, Schneider L, Halder M, Demmig R, Baack M, Cladière D, Walter M, Al Abdallah H, Kleinhempel C, Müller J, Passarelli F, Wehrle P, Heim A, Wassmann K, Mayer TU
Citation:
bioRxiv. 2022;[preprint] doi: doi:10.1101/2022.06.04.494806
Epub:
Not Epub
Abstract:
To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.04.494806v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Bouftas N, Schneider L, Halder M, Demmig R, Baack M, Cladière D, Walter M, Al Abdallah H, Kleinhempel C, Müller J, Passarelli F, Wehrle P, Heim A, Wassmann K, Mayer TU. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization. bioRxiv. 2022;[preprint] doi: doi:10.1101/2022.06.04.494806.

Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure

Authors:
Christodoulou N, Skourides PA
Citation:
Development. 2022;[Epub] doi:10.1242/dev.200358
Epub:
Yes
Abstract:
Neural tube closure (NTC) is a fundamental process during vertebrate development and is indispensable for the formation of the...
Link:
https://journals.biologists.com/dev/article-abstract/doi/10.1242/dev.200358/275604/Distinct-spatiotemporal-contribution-of
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Christodoulou N, Skourides PA. Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure. Development. 2022;[Epub] doi:10.1242/dev.200358.

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Authors:
Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM
Citation:
Cells. 2022;11:1840. doi:10.3390/cells11111840
Epub:
Not Epub
Abstract:
CLN5 disease (MIM: 256731) represents a rare late-infantile form of neuronal ceroid lipofuscinosis (NCL), caused by mutations...
Link:
https://www.mdpi.com/2073-4409/11/11/1840
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM. Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease. Cells. 2022;11:1840. doi:10.3390/cells11111840.

U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma

Authors:
Vorlova S, Blahetek G, Barbieri R, Kerstan Y, Rosa A, Bundalo M, Egg M, Butt E, Henke E, Dölken L, Houben R, Schilling B, Fischer U, Erhard F, Zernecke A
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.01.479622
Epub:
Not Epub
Abstract:
Activation of intronic polyadenylation signals results in premature cleavage and polyadenylation (PCPA). The majority of...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.01.479622v1
Delivery Method:
Vivo-Morpholino Endo-Porter
Organism or Cell Type:
cell culture: UACC-257, HeLe
Citation Extract:
Vorlova S, Blahetek G, Barbieri R, Kerstan Y, Rosa A, Bundalo M, Egg M, Butt E, Henke E, Dölken L, Houben R, Schilling B, Fischer U, Erhard F, Zernecke A. U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.01.479622.

Ultrasensitive Detection of Exosomal miRNA with PMO- Graphene Quantum Dots Functionalized Field Effect Transistor Biosensor

Authors:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao M-M, Zhang Z-Y, Zhang G-J
Citation:
iScience. 2022;[Epub] doi:10.1016/j.isci.2022.104522
Epub:
Not Epub
Abstract:
Compared to the conventional DNA probe immobilization on the planar surface, nanoparticles-based DNA probes enable more RNA...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(22)00793-3.pdf
Citation Extract:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao M-M, Zhang Z-Y, Zhang G-J. Ultrasensitive Detection of Exosomal miRNA with PMO- Graphene Quantum Dots Functionalized Field Effect Transistor Biosensor. iScience. 2022;[Epub] doi:10.1016/j.isci.2022.104522.

Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

Authors:
Sánchez-Iranzo H, Halavatyi A, Diz-Muñoz A
Citation:
eLife. 2022;11:e75429. doi:10.7554/eLife.75429
Epub:
Not Epub
Abstract:
Development of multicellular organisms requires the generation of gene expression patterns that determines cell fate and organ...
Link:
https://elifesciences.org/articles/75429
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sánchez-Iranzo H, Halavatyi A, Diz-Muñoz A. Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord. eLife. 2022;11:e75429. doi:10.7554/eLife.75429.

Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy

Authors:
Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X, Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y
Citation:
Prog Neurobiol. 2022 May 30:102288. doi: 10.1016/j.pneurobio.2022.102288. Online ahead of print
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and is characterized by neurobehavioural...
Link:
https://www.sciencedirect.com/science/article/pii/S0301008222000740
Delivery Method:
intracerebroventricular (i.c.v.) infusion
Organism or Cell Type:
mice
Citation Extract:
Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X, Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y. Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy. Prog Neurobiol. 2022 May 30:102288. doi: 10.1016/j.pneurobio.2022.102288. Online ahead of print.

Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish

Authors:
Chen H, Qiu W, Yang X, Chen F, Chen J, Tang L, Zhong H, Magnuson JT, Zheng C, Xu EG
Citation:
Environ Sci Technol. 2022 Jun 2. doi: 10.1021/acs.est.1c08875. Online ahead of print
Epub:
Not Epub
Abstract:
Perfluorooctane sulfonamide (PFOSA), a precursor of perfluorooctanesulfonate (PFOS), is widely used during industrial processes...
Link:
https://pubs.acs.org/doi/10.1021/acs.est.1c08875
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen H, Qiu W, Yang X, Chen F, Chen J, Tang L, Zhong H, Magnuson JT, Zheng C, Xu EG. Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish. Environ Sci Technol. 2022 Jun 2. doi: 10.1021/acs.est.1c08875. Online ahead of print.

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