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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway

Authors:
Wei G, Zhang X, Cai C, Sheng J, Xu M, Wang C, Gu Q, Guo C, Chen F, Liu D, Qian F
Citation:
Front Cell Neurosci. 2022;16:840143. doi:10.3389/fncel.2022.840143
Epub:
Not Epub
Abstract:
Most cases of acquired hearing loss are due to degeneration and subsequent loss of cochlear hair cells. Whereas mammalian hair...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wei G, Zhang X, Cai C, Sheng J, Xu M, Wang C, Gu Q, Guo C, Chen F, Liu D, Qian F. Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Front Cell Neurosci. 2022;16:840143. doi:10.3389/fncel.2022.840143.

Gold Nanoparticles Conjugated Dna-Tiles for Simultaneous Delivery of Morpholino Antisense Oligonucleotides and Doxorubicin

Authors:
Tunc CU, Çulha M
Citation:
2022. SSRN;JDDST-D-22-00401:[preprint] doi:10.2139/ssrn.4048799
Epub:
Not Epub
Abstract:
Current therapies have limited treatment effect on cancer. Combinational delivery of multiple therapeutics has been commonly...
Delivery Method:
nanoparticle
Organism or Cell Type:
cell culture: breast cancer
Citation Extract:
Tunc CU, Çulha M. Gold Nanoparticles Conjugated Dna-Tiles for Simultaneous Delivery of Morpholino Antisense Oligonucleotides and Doxorubicin. 2022. SSRN;JDDST-D-22-00401:[preprint] doi:10.2139/ssrn.4048799 .

Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

Authors:
Ahmed M, Kojima Y, Masai I
Citation:
eLife. 2022;11:e74650 doi:10.7554/eLife.74650
Epub:
Not Epub
Abstract:
In the vertebrate retina, an interplay between retinal ganglion cells (RGCs), amacrine (AC), and bipolar (BP) cells establishes...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahmed M, Kojima Y, Masai I. Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation. eLife. 2022;11:e74650 doi:10.7554/eLife.74650.

Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients

Authors:
Alkowari M, Espino-Guarch M, Daas S, Abdelrahman D, Hasan W, Krishnamoorthy N, Sathappan A, Sheehan P, Van Panhuys N, The Qatar Genome Program Research Consortium, Estivill X
Citation:
Int J Mol Sci. 2022;23:3369. doi:10.3390/ijms23063369
Epub:
Not Epub
Abstract:
Hereditary hearing loss (HHL) is a common genetic disorder accounting for at least 60% of pre-lingual deafness in children, of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Alkowari M, Espino-Guarch M, Daas S, Abdelrahman D, Hasan W, Krishnamoorthy N, Sathappan A, Sheehan P, Van Panhuys N, The Qatar Genome Program Research Consortium, Estivill X. Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients. Int J Mol Sci. 2022;23:3369. doi:10.3390/ijms23063369.

Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype

Authors:
Subramaniam S, Liu J, Fletcher C, Ramchandran R, Weiler H
Citation:
Front Cell Dev Biol. 10:852989. doi:10.3389/fcell.2022.852989
Epub:
Not Epub
Abstract:
Tissue factor (TF) is crucial for embryogenesis, as mice lacking TF are embryonically lethal (E10.5). This lethality may be...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Subramaniam S, Liu J, Fletcher C, Ramchandran R, Weiler H. Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype. Front Cell Dev Biol. 10:852989. doi:10.3389/fcell.2022.852989.

Exonization by the Emergence of a Cleavage-Polyadenylation Site

Authors:
Méreau A, Lerivray H, Viet J, Hardy S, Paillard L, Audic Y
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.03.17.484714
Epub:
Not Epub
Abstract:
Exonization is the evolutionary process of recruitment of new exonic regions from previously intronic regions. It is a major...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Méreau A, Lerivray H, Viet J, Hardy S, Paillard L, Audic Y. Exonization by the Emergence of a Cleavage-Polyadenylation Site. bioRxiv. 2022;[preprint] doi:10.1101/2022.03.17.484714.

Interaction of transcription factors Islet2 and Nr2f1b to control vascular patterning during zebrafish development

Authors:
Wang YS, Huang YS, Chiu CC, Wu TY, Zhou JQ, Liang SR, Tai MH, Wu CY
Citation:
Biochem Biophys Res Commun. 2022 Mar 9;604:123-129. doi: 10.1016/j.bbrc.2022.03.042. Online ahead of print
Epub:
Not Epub
Abstract:
Many regulators controlling arterial identity are well described; however, transcription factors that promote vein identity and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang YS, Huang YS, Chiu CC, Wu TY, Zhou JQ, Liang SR, Tai MH, Wu CY. Interaction of transcription factors Islet2 and Nr2f1b to control vascular patterning during zebrafish development. Biochem Biophys Res Commun. 2022 Mar 9;604:123-129. doi: 10.1016/j.bbrc.2022.03.042. Online ahead of print.

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish

Authors:
Sharma B, Subramaniam YJ, Ayyappa Raja D, Aggarwal A, Sivasubbu S, Natarajan VT
Citation:
J Vis Exp. 2022 Mar 1;(181):e62955. doi: 10.3791/62955
Epub:
Not Epub
Abstract:
Melanocytes are specialized neural crest-derived cells present in the epidermal skin. These cells synthesize melanin pigment...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma B, Subramaniam YJ, Ayyappa Raja D, Aggarwal A, Sivasubbu S, Natarajan VT. Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish. J Vis Exp. 2022 Mar 1;(181):e62955. doi: 10.3791/62955.

Complete Depletion of Primordial Germ Cells Results in Masculinization of Monopterus albus, a Protogynous Hermaphroditic Fish

Authors:
Hou M, Feng K, Luo H, Jiang Y, Xu W, Li Y, Song Y, Chen J, Tao B, Zhu Z, Hu W
Citation:
Mar Biotechnol (NY). 2022 Mar 18. doi: 10.1007/s10126-022-10106-2. Online ahead of print
Epub:
Yes
Abstract:
Primordial germ cells (PGCs) play an important role in sexual fate determination and gonadal development in gonochoristic fish...
Delivery Method:
microinjection
Organism or Cell Type:
Monopterus albus (rice field eel)
Citation Extract:
Hou M, Feng K, Luo H, Jiang Y, Xu W, Li Y, Song Y, Chen J, Tao B, Zhu Z, Hu W. Complete Depletion of Primordial Germ Cells Results in Masculinization of Monopterus albus, a Protogynous Hermaphroditic Fish. Mar Biotechnol (NY). 2022 Mar 18. doi: 10.1007/s10126-022-10106-2. Online ahead of print.

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis

Authors:
Haraoka Y, Akieda Y, Nagai Y, Mogi C, Ishitani T
Citation:
Nat Commun. 2022;13(1):1417. doi:10.1038/s41467-022-29061-6
Epub:
Not Epub
Abstract:
Most tumours are thought to arise through oncogenic cell generation followed by additional mutations. How a new oncogenic cell...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Haraoka Y, Akieda Y, Nagai Y, Mogi C, Ishitani T. Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nat Commun. 2022;13(1):1417. doi:10.1038/s41467-022-29061-6.

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