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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function
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Citation:
Cell Biosci. 2022 Jul 6;12(1):103. doi: 10.1186/s13578-022-00838-y Epub:
Not Epub Abstract:
Background: Neurodegenerative diseases encompass an extensive and heterogeneous group of nervous system disorders which are... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen X, Liu F, Li B, Wang Y, Yuan L, Yin A, Chen Q, Hu W, Yao Y, Zhang M, Wu Y, Chen K. Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function. Cell Biosci. 2022 Jul 6;12(1):103. doi: 10.1186/s13578-022-00838-y. |
Use of vivo-morpholinos for gene knockdown in the postnatal shark retina
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.07.11.499558 Epub:
Not Epub Abstract:
Work in the catshark Scyliorhinus canicula has shown that the evolutionary origin of postnatal neurogenesis in vertebrates is... Delivery Method:
Vivo-Morpholino intraocular injection Organism or Cell Type:
Scyliorhinus canicula (catshark) Citation Extract: Rodríguez-Arrizabalaga M, Hernández-Núñez I, Candal E, Barreiro-Iglesias A. Use of vivo-morpholinos for gene knockdown in the postnatal shark retina. bioRxiv. 2022;[preprint] doi:10.1101/2022.07.11.499558 . |
dmrt2 and myf5 Link Early Somitogenesis to Left-Right Axis Determination in Xenopus laevis
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Citation:
Front Cell Dev Biol. 2022 Jun 23;10:858272. doi: 10.3389/fcell.2022.858272. eCollection 2022 Epub:
Not Epub Abstract:
The vertebrate left-right axis is specified during neurulation by events occurring in a transient ciliated epithelium termed... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Tingler M, Brugger A, Feistel K, Schweickert A. dmrt2 and myf5 Link Early Somitogenesis to Left-Right Axis Determination in Xenopus laevis. Front Cell Dev Biol. 2022 Jun 23;10:858272. doi: 10.3389/fcell.2022.858272. eCollection 2022. |
Inhibition of Epidermal Growth Factor Receptor Signaling by Antisense Oligonucleotides as a Novel Approach to Epidermal Growth Factor Receptor Inhibition
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Citation:
Nucleic Acid Ther. 2022 Jul 20. doi: 10.1089/nat.2021.0101. Online ahead of print Epub:
Not Epub Abstract:
The one-carbon metabolism (OCM) pathway provides purines and thymidine for synthesis of nucleic acids required for cell... Link:
Organism or Cell Type:
cell culture, Ovis aries (sheep) Citation Extract: Madanayake TW, Welsh EA, Darville LNF, Koomen JM, Chalfant CE, Haura EB, Robinson TJ. Inhibition of Epidermal Growth Factor Receptor Signaling by Antisense Oligonucleotides as a Novel Approach to Epidermal Growth Factor Receptor Inhibition. Nucleic Acid Ther. 2022 Jul 20. doi: 10.1089/nat.2021.0101. Online ahead of print. |
Knockdown of myorg leads to brain calcification in zebrafish
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Citation:
Mol Brain. 2022 Jul 23;15(1):65. doi: 10.1186/s13041-022-00953-4 Epub:
Not Epub Abstract:
Primary familial brain calcification (PFBC) is a neurogenetic disorder characterized by bilateral calcified deposits in the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhao M, Lin XH, Zeng YH, Su HZ, Wang C, Yang K, Chen YK, Lin BW, Yao XP, Chen WJ. Knockdown of myorg leads to brain calcification in zebrafish. Mol Brain. 2022 Jul 23;15(1):65. doi: 10.1186/s13041-022-00953-4. |
Inhibition of Epidermal Growth Factor Receptor Signaling by Antisense Oligonucleotides as a Novel Approach to Epidermal Growth Factor Receptor Inhibition
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Citation:
Nucleic Acid Ther. 2022 Jul 20. doi: 10.1089/nat.2021.0101. Online ahead of print Epub:
Yes Abstract:
We report a novel method to inhibit epidermal growth factor receptor (EGFR) signaling using custom morpholino antisense... Organism or Cell Type:
cell culture: models of non-small cell lung cancer (NSCLC) including PC9 and PC9GR Citation Extract: Madanayake TW, Welsh EA, Darville LNF, Koomen JM, Chalfant CE, Haura EB, Robinson TJ. Inhibition of Epidermal Growth Factor Receptor Signaling by Antisense Oligonucleotides as a Novel Approach to Epidermal Growth Factor Receptor Inhibition. Nucleic Acid Ther. 2022 Jul 20. doi: 10.1089/nat.2021.0101. Online ahead of print. |
De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with intellectual disabilities and documentation of functional relevance through zebrafish rescue and cellular transfection experiments
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Citation:
Hum Mol Genet. 2022 Jul 21:ddac166. doi: 10.1093/hmg/ddac166. Online ahead of print Epub:
Yes Abstract:
Collapsin response mediator protein 2 (Crmp2) is an evolutionarily well-conserved tubulin-binding cytosolic protein that plays... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Suzuki H, Li S, Tokutomi T, Takeuchi C, Takahashi M, Yamada M, Okuno H, Miya F, Takenouchi T, Numabe H, Kosaki K, Ohshima T. De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with intellectual disabilities and documentation of functional relevance through zebrafish rescue and cellular transfection experiments. Hum Mol Genet. 2022 Jul 21:ddac166. doi: 10.1093/hmg/ddac166. Online ahead of print. |
Clock genes rescue nphp mutations in zebrafish
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Citation:
Hum Mol Genet. 2022 Jul 21:ddac160. doi: 10.1093/hmg/ddac160. Online ahead of print Epub:
Yes Abstract:
The zebrafish pronephros model, using morpholino oligonucleotides (MO) to deplete target genes, has been extensively used to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kayser N, Zaiser F, Veenstra AC, Wang H, Göcmen B, Eckert P, Franz H, Köttgen A, Walz G, Yakulov TA. Clock genes rescue nphp mutations in zebrafish. Hum Mol Genet. 2022 Jul 21:ddac160. doi: 10.1093/hmg/ddac160. Online ahead of print. |
Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer
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Citation:
J Org Chem. 2022 Jul 15; 87(15):9466–78. doi: 10.1021/acs.joc.2c00265. Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) constitute 3 out of the 11 FDA-approved oligonucleotide-based drugs in... Citation Extract: Kundu J, Ghosh A, Ghosh U, Das A, Nagar D, Pattanayak S, Ghose A, Sinha S. Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer. J Org Chem. 2022 Jul 15; 87(15):9466–78. doi: 10.1021/acs.joc.2c00265. . |
Model of neural induction in the ascidian embryo
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.29.498205 Epub:
Not Epub Abstract:
How cell specification can be controlled in a reproducible manner is a fundamental question in development biology. In... Delivery Method:
microinjection Organism or Cell Type:
Ciona sp. (ascidian) Citation Extract: Bettoni R, Hudson C, Yasuo H, de Buyl S, Dupont G. Model of neural induction in the ascidian embryo. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.29.498205. |