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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Authors:
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf K, Fresard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.04.29.489435
Epub:
Not Epub
Abstract:
In aging, skeletal muscle strength and regenerative capacity declines due, in part, to functional impairment of muscle stem...
Link:
https://www.biorxiv.org/content/10.1101/2022.04.29.489435v1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: mouse muscle stem cells
Citation Extract:
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf K, Fresard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. bioRxiv. 2022;[preprint] doi:10.1101/2022.04.29.489435.

Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide

Authors:
Wolińska-Nizioł L, Romaniuk K, Wojciechowska K, Surga K, Kamaszewski M, Szudrowicz H, Miączyńska M
Citation:
FEBS Open Bio. 2022 May 3. doi: 10.1002/2211-5463.13423. Online ahead of print
Epub:
Not Epub
Abstract:
Tollip is a multifunctional adaptor protein implicated in innate immunity, lysosomal trafficking/autophagy of protein...
Link:
https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13423
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wolińska-Nizioł L, Romaniuk K, Wojciechowska K, Surga K, Kamaszewski M, Szudrowicz H, Miączyńska M. Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide. FEBS Open Bio. 2022 May 3. doi: 10.1002/2211-5463.13423. Online ahead of print.

Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish

Authors:
Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J
Citation:
Sci Rep. 2022 May 4;12(1):7312. doi: 10.1038/s41598-022-11002-4
Epub:
Not Epub
Abstract:
Phospholipids in the membrane consist of diverse pairs of fatty acids bound to a glycerol backbone. The biological significance...
Link:
https://www.nature.com/articles/s41598-022-11002-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J. Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Sci Rep. 2022 May 4;12(1):7312. doi: 10.1038/s41598-022-11002-4.

Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro

Authors:
Gupta A, Gupta S, Das U, Sinha S
Citation:
Bioconjugate Chem. 2022;[Epub] doi:10.1021/acs.bioconjchem.2c00129
Epub:
Not Epub
Abstract:
Cell-penetrating peptides (CPPs) are structurally diverse sophisticated tools endowed with high arginine content,...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00129
Delivery Method:
azaproline-tetraguanidinium transporter "FAT"
Organism or Cell Type:
cell culture: CHO cells, human carcinoma cells
Citation Extract:
Gupta A, Gupta S, Das U, Sinha S. Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro. Bioconjugate Chem. 2022;[Epub] doi:10.1021/acs.bioconjchem.2c00129.

Agonists of prostaglandin E2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies

Authors:
Garcia H, Serafin AS, Silbermann F, Porée E, Viau A, Mahaut C, Billot K, Birgy É, Garfa-Traore M, Roy S, Ceccarelli S, Mehraz M, Rodriguez PC, Deleglise B, Furio L, Jabot-Hanin F, Cagnard N, Del Nery E, Fila M, Sin-Monnot S, Antignac C, Lyonnet S, Krug P, Salomon R, Annereau J-P, Benmerah A, Delous M, Briseño-Roa L, Saunier S
Citation:
Proc Nat Acad Sci USA. 2022;[Epub] doi:10.1073/pnas.2115960119
Epub:
Yes
Abstract:
Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging to the ciliopathy disorders and known...
Link:
https://www.pnas.org/doi/10.1073/pnas.2115960119
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Garcia H, Serafin AS, Silbermann F, Porée E, Viau A, Mahaut C, Billot K, Birgy É, Garfa-Traore M, Roy S, Ceccarelli S, Mehraz M, Rodriguez PC, Deleglise B, Furio L, Jabot-Hanin F, Cagnard N, Del Nery E, Fila M, Sin-Monnot S, Antignac C, Lyonnet S, Krug P, Salomon R, Annereau J-P, Benmerah A, Delous M, Briseño-Roa L, Saunier S. Agonists of prostaglandin E2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies. Proc Nat Acad Sci USA. 2022;[Epub] doi:10.1073/pnas.2115960119.

The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment

Authors:
Hardin WR, Alas GCM, Taparia N, Thomas EB, Steele-Ogus MC, Hvorecny KL, Halpern AR, Tůmová P, Kollman JM, Vaughan JC, Sniadecki NJ, Paredez AR
Citation:
PLoS Pathog. 2022;18(4):e1010496. doi:10.1371/journal.ppat.1010496
Epub:
Not Epub
Abstract:
Attachment to the intestinal epithelium is critical to the lifestyle of the ubiquitous parasite Giardia lamblia. The...
Link:
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010496
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Hardin WR, Alas GCM, Taparia N, Thomas EB, Steele-Ogus MC, Hvorecny KL, Halpern AR, Tůmová P, Kollman JM, Vaughan JC, Sniadecki NJ, Paredez AR. The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment. PLoS Pathog. 2022;18(4):e1010496. doi:10.1371/journal.ppat.1010496.

Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction

Authors:
Weng S, Huebner RJ, Wallingford JB
Citation:
Cell Rep. 2022;39:110666. doi:10.1016/j.celrep.2022.110666
Epub:
Not Epub
Abstract:
Convergent extension (CE) is an evolutionarily conserved collective cell movement that elongates several organ systems during...
Link:
https://www.cell.com/cell-reports/pdf/S2211-1247(22)00418-1.pdf
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Weng S, Huebner RJ, Wallingford JB. Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction. Cell Rep. 2022;39:110666. doi:10.1016/j.celrep.2022.110666.

ARVCF catenin controls force production during vertebrate convergent extension

Authors:
Huebner RJ, Weng S, Lee C, Sarikaya S, Papoulas O, Cox RM, Marcotte EM, Wallingford JB
Citation:
Dev Cell. 2022;[Epub] doi:10.1016/j.devcel.2022.04.001
Epub:
Not Epub
Abstract:
The design of an animal’s body plan is encoded in the genome, and the execution of this program is a mechanical progression...
Link:
https://www.cell.com/developmental-cell/pdf/S1534-5807(22)00241-6.pdf
Organism or Cell Type:
Xenopus
Citation Extract:
Huebner RJ, Weng S, Lee C, Sarikaya S, Papoulas O, Cox RM, Marcotte EM, Wallingford JB. ARVCF catenin controls force production during vertebrate convergent extension. Dev Cell. 2022;[Epub] doi:10.1016/j.devcel.2022.04.001.

Left-right symmetry of zebrafish embryos requires somite surface tension

Authors:
Naganathan SR, Popović M, Oates AC
Citation:
Nature. 2022;[Epub ahead of print] doi:10.1038/s41586-022-04646-9
Epub:
Yes
Abstract:
The body axis of vertebrate embryos is periodically segmented into bilaterally symmetric pairs of somites2. The anteroposterior...
Link:
https://www.nature.com/articles/s41586-022-04646-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Naganathan SR, Popović M, Oates AC. Left-right symmetry of zebrafish embryos requires somite surface tension. Nature. 2022;[Epub ahead of print] doi:10.1038/s41586-022-04646-9.

FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

Authors:
Yang SY, Hayer KE, Fazelinia H, Asnani M, Black KL, Naqvi AS, Pillai V, Spruce LA, Barash Y, Elenitoba-Johnson KSJ, Thomas-Tikhonenko A
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.04.24.489313
Epub:
Not Epub
Abstract:
Non-canonical exon usage plays many important roles in cellular phenotypes, but its contribution to human B-cell development...
Link:
https://www.biorxiv.org/content/10.1101/2022.04.24.489313v1
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: REH from B-Cell Acute Lymphoblastic Leukemia patients
Citation Extract:
Yang SY, Hayer KE, Fazelinia H, Asnani M, Black KL, Naqvi AS, Pillai V, Spruce LA, Barash Y, Elenitoba-Johnson KSJ, Thomas-Tikhonenko A. FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells. bioRxiv. 2022;[preprint] doi:10.1101/2022.04.24.489313.

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