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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury

Authors:
Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F
Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231
Epub:
Not Epub
Abstract:
Background: Reversion of activated hepatic stellate cells (HSCs) to quiescence is likely to be a promising pathway in liver...
Link:
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.R4231
Organism or Cell Type:
mice
Citation Extract:
Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F. microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231.

Casimersen for the treatment of Duchenne muscular dystrophy

Authors:
Zakeri SE, Pradeep SP, Kasina V, Laddha AP, Manautou JE, Bahal R
Citation:
Trends Pharmacol Sci. 2022 May 14:S0165-6147(22)00089-X. doi: 10.1016/j.tips.2022.04.009. Online ahead of print
Epub:
Not Epub
Abstract:
Casimersen is a single-stranded, antisense phosphorodiamidate morpholino oligonucleotide where six-membered morpholino rings...
Link:
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(22)00089-X
Citation Extract:
Zakeri SE, Pradeep SP, Kasina V, Laddha AP, Manautou JE, Bahal R. Casimersen for the treatment of Duchenne muscular dystrophy. Trends Pharmacol Sci. 2022 May 14:S0165-6147(22)00089-X. doi: 10.1016/j.tips.2022.04.009. Online ahead of print.

SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine

Authors:
Wang ZW, Pan JJ, Hu JF, Zhang JQ, Huang L, Huang Y, Liao CY, Yang C, Chen ZW, Wang YD, Shen BY, Tian YF, Chen S
Citation:
Cell Rep. 2022 May 10;39(6):110813. doi: 10.1016/j.celrep.2022.110813
Epub:
Not Epub
Abstract:
Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative splicing of more than 90% of protein-coding genes,...
Link:
https://www.cell.com/cell-reports/pdfExtended/S2211-1247(22)00584-8
Organism or Cell Type:
cell culture: human pancreatic cancer Panc1 and BXPC3
Citation Extract:
Wang ZW, Pan JJ, Hu JF, Zhang JQ, Huang L, Huang Y, Liao CY, Yang C, Chen ZW, Wang YD, Shen BY, Tian YF, Chen S. SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine. Cell Rep. 2022 May 10;39(6):110813. doi: 10.1016/j.celrep.2022.110813.

Single cell transcriptomics identifies conserved regulators of neurosecretory lineages

Authors:
Steger J, Cole AG, Denner A, Lebedeva T, Genikhovich G, Ries A, Reischl R, Taudes E, Lassnig M, Technau U
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.11.491463
Epub:
Not Epub
Abstract:
Communication in bilaterian nervous systems is mediated by electrical and secreted signals, however, the evolutionary origin...
Link:
https://www.biorxiv.org/content/10.1101/2022.05.11.491463v1
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Steger J, Cole AG, Denner A, Lebedeva T, Genikhovich G, Ries A, Reischl R, Taudes E, Lassnig M, Technau U. Single cell transcriptomics identifies conserved regulators of neurosecretory lineages. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.11.491463.

The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium

Authors:
Yadav S, Chawla B, Khursheed MA, Ramachandran R, Bachhawat AK
Citation:
Biochem J. 2019;476(13):1857-73
Epub:
Not Epub
Abstract:
Calcium signaling is essential for embryonic development but the signals upstream of calcium are only partially understood....
Link:
https://portlandpress.com/biochemj/article-abstract/476/13/1857/219605/The-glutathione-degrading-enzyme-Chac1-is-required
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yadav S, Chawla B, Khursheed MA, Ramachandran R, Bachhawat AK. The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium. Biochem J. 2019;476(13):1857-73.

Double-Lariat Caged Morpholino Oligonucleotides for Optical Gene Silencing

Authors:
Pattanayak S, Deiters A, Chen J
Citation:
chemRxiv. 2022;[preprint] doi:10.26434/chemrxiv-2022-z6shp
Epub:
Not Epub
Abstract:
Caged morpholino oligonucleotides (cMOs) are synthetic tools that allow light-inducible gene silencing in live organisms....
Link:
https://chemrxiv.org/engage/chemrxiv/article-details/627b47dc809e3262938b9c11
Organism or Cell Type:
zebrafish
Citation Extract:
Pattanayak S, Deiters A, Chen J. Double-Lariat Caged Morpholino Oligonucleotides for Optical Gene Silencing. chemRxiv. 2022;[preprint] doi:10.26434/chemrxiv-2022-z6shp.

A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness

Authors:
Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R
Citation:
J Am Soc Nephrol. 2022 Apr;33(4):732-745. doi:10.1681/ASN.2021101312. Epub 2022 Feb 11
Epub:
Not Epub
Abstract:
Background: The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to...
Link:
https://jasn.asnjournals.org/content/33/4/732.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R. A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness. J Am Soc Nephrol. 2022 Apr;33(4):732-745. doi:10.1681/ASN.2021101312. Epub 2022 Feb 11.

Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling

Authors:
Afouda BA, Hoppler S
Citation:
Dev Dyn. 2011 Mar;240(3):649-62. doi:10.1002/dvdy.22570. Epub 2011 Feb 8
Epub:
Not Epub
Abstract:
GATA factors and Wnt signals are key regulators of vertebrate cardiogenesis, but specific roles for individual GATA factors and...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.22570
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Afouda BA, Hoppler S. Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling. Dev Dyn. 2011 Mar;240(3):649-62. doi:10.1002/dvdy.22570. Epub 2011 Feb 8.

FoxN3 knock-down alters spatio-temporal expression patterns of genes involved in cranial cartilage and muscle development in the African clawed-frog Xenopus laevis

Authors:
Schmidt J, Schuff M, Naumann B, Olsson L
Citation:
Vertebr Zool. 2020;70(3)455-72. doi:10.26049/VZ70-3-2020-14
Epub:
Not Epub
Abstract:
What is the gene regulatory network underlying the morphogenesis of the vertebrate head skeleton? A good candidate to approach...
Link:
https://www.senckenberg.de/wp-content/uploads/2020/09/14_vertebrate_zoology_70_3_2020_Schmidt.pdf
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schmidt J, Schuff M, Naumann B, Olsson L. FoxN3 knock-down alters spatio-temporal expression patterns of genes involved in cranial cartilage and muscle development in the African clawed-frog Xenopus laevis. Vertebr Zool. 2020;70(3)455-72. doi:10.26049/VZ70-3-2020-14.

Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2

Authors:
Capon SJ, Uribe V, Dominado N, Ehrlich O, Smith KA
Citation:
Development. 2022 May 1;149(9):dev190421. doi: 10.1242/dev.190421. Epub 2022 May 9
Epub:
Not Epub
Abstract:
The endocardium plays important roles in the development and function of the vertebrate heart; however, few molecular markers...
Link:
https://journals.biologists.com/dev/article/149/9/dev190421/275317/Endocardial-identity-is-established-during-early
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Capon SJ, Uribe V, Dominado N, Ehrlich O, Smith KA. Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development. 2022 May 1;149(9):dev190421. doi: 10.1242/dev.190421. Epub 2022 May 9.

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