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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
PTEN inhibits AMPK to control collective migration
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Citation:
Nat Commun. 2022 Aug 11;13(1):4528. doi: 10.1038/s41467-022-31842-y Epub:
Not Epub Abstract:
Pten is one of the most frequently mutated tumour suppressor gene in cancer. PTEN is generally altered in invasive cancers such... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Peglion F, Capuana L, Perfettini I, Boucontet L, Braithwaite B, Colucci-Guyon E, Quissac E, Forsberg-Nilsson K, Llense F, Etienne-Manneville S. PTEN inhibits AMPK to control collective migration. Nat Commun. 2022 Aug 11;13(1):4528. doi: 10.1038/s41467-022-31842-y. |
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base
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Citation:
Elife. 2022 Aug 25;11:e81016. doi: 10.7554/eLife.81016. Online ahead of print Epub:
Not Epub Abstract:
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Jang DG, Kwon KY, Kweon YC, Kim BG, Myung K, Lee HS, Young Park C, Kwon T, Park TJ. GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base. Elife. 2022 Aug 25;11:e81016. doi: 10.7554/eLife.81016. Online ahead of print. |
TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration
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Citation:
Nucleic Acids Res. 2022 Aug 10:gkac659. doi: 10.1093/nar/gkac659. Online ahead of print Epub:
Not Epub Abstract:
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5′-monomethylguanosine cap of small nuclear... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Galati A, Palumbo V, Kobin MA, Tartaglia GG, Colantoni A, Proietti G, Wu Y, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Schiavi ED, Gatti M, Artandi SE, Raffa GD. TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Res. 2022 Aug 10:gkac659. doi: 10.1093/nar/gkac659. Online ahead of print. |
Co-option of the piRNA pathway to regulate neural crest specification
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Citation:
Sci Adv. 2022 Aug 12;8(32):eabn1441. doi: 10.1126/sciadv.abn1441. Epub 2022 Aug 10 Epub:
Not Epub Abstract:
Across Metazoa, Piwi proteins play a critical role in protecting the germline genome through piRNA-mediated repression of... Delivery Method:
electroporation Organism or Cell Type:
Gallus gallus (chick) Citation Extract: Galton R, Fejes-Toth K, Bronner ME. Co-option of the piRNA pathway to regulate neural crest specification. Sci Adv. 2022 Aug 12;8(32):eabn1441. doi: 10.1126/sciadv.abn1441. Epub 2022 Aug 10. |
Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis
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Citation:
EBioMedicine. 2022 Aug 2:104202. doi: 10.1016/j.ebiom.2022.104202. Online ahead of print Epub:
Not Epub Abstract:
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with heterogeneous aetiology and a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chaytow H, Carroll E, Gordon D, Huang YT, van der Hoorn D, Smith HL, Becker T, Becker CG, Faller KME, Talbot K, Gillingwater TH. Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis. EBioMedicine. 2022 Aug 2:104202. doi: 10.1016/j.ebiom.2022.104202. Online ahead of print. |
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates
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Citation:
EMBO J. 2022 Aug 4:e108536. doi: 10.15252/embj.2021108536. Online ahead of print Epub:
Not Epub Abstract:
During development, hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium and will expand in a transient... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cacialli P, Mailhe MP, Wagner I, Merkler D, Golub R, Bertrand JY. Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. EMBO J. 2022 Aug 4:e108536. doi: 10.15252/embj.2021108536. Online ahead of print. |
A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype
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Citation:
Biomedicines. 2022;10(8):1814. doi:10.3390/biomedicines10081814 Epub:
Not Epub Abstract:
NOP56 belongs to a C/D box small nucleolar ribonucleoprotein complex that is in charge of cleavage and modification of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Quelle-Regaldie A, Folgueira M, Yáñez J, Sobrido-Cameán D, Alba-González A, Barreiro-Iglesias A, Sobrido M-J, Sánchez L. A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype. Biomedicines. 2022;10(8):1814. doi:10.3390/biomedicines10081814. |
Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly
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Citation:
Nucleic Acids Res. 2022 Aug 12;50(14):8262-8278. doi: 10.1093/nar/gkac636 Epub:
Not Epub Abstract:
We recently reported that serine-arginine-rich (SR) protein-mediated pre-mRNA structural remodeling generates a pre-mRNA 3D... Delivery Method:
transfection Organism or Cell Type:
cell culture: HeLa Citation Extract: Saha K, Ghosh G. Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly. Nucleic Acids Res. 2022 Aug 12;50(14):8262-8278. doi: 10.1093/nar/gkac636. |
MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia
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Citation:
Mov Disord. 2022 Jul 25. doi: 10.1002/mds.29147. Online ahead of print Epub:
Yes Abstract:
Background: Despite advances in next generation sequencing technologies, the identification of variants of uncertain... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, Grozeva D, Carss K, Smith M, Pall H, Lunt P, De Gressi S, Kamsteeg EJ, Haack TB, Carr L, Guerreiro R, Bras J, Maher ER, Scott RH, Vandenberg RJ, Raymond FL, Chong WK, Sudhakar S, Mankad K, Reith ME, Campeau PM, Harvey RJ, Kurian MA. MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Mov Disord. 2022 Jul 25. doi: 10.1002/mds.29147. Online ahead of print. |
The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity
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Citation:
Sci Adv. 2022;8(29)eabo0155 doi:10.1126/sciadv.abo01 Epub:
Not Epub Abstract:
Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Paradis M, Kucharowski N, Edwards Faret G, Palacios SJM, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow MH. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Sci Adv. 2022;8(29)eabo0155 doi:10.1126/sciadv.abo01. |