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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish

Authors:
Sharma B, Subramaniam YJ, Ayyappa Raja D, Aggarwal A, Sivasubbu S, Natarajan VT
Citation:
J Vis Exp. 2022 Mar 1;(181):e62955. doi: 10.3791/62955
Epub:
Not Epub
Abstract:
Melanocytes are specialized neural crest-derived cells present in the epidermal skin. These cells synthesize melanin pigment...
Link:
https://www.jove.com/t/62955/reverse-genetic-approach-to-identify-regulators-pigmentation-using
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma B, Subramaniam YJ, Ayyappa Raja D, Aggarwal A, Sivasubbu S, Natarajan VT. Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish. J Vis Exp. 2022 Mar 1;(181):e62955. doi: 10.3791/62955.

Complete Depletion of Primordial Germ Cells Results in Masculinization of Monopterus albus, a Protogynous Hermaphroditic Fish

Authors:
Hou M, Feng K, Luo H, Jiang Y, Xu W, Li Y, Song Y, Chen J, Tao B, Zhu Z, Hu W
Citation:
Mar Biotechnol (NY). 2022 Mar 18. doi: 10.1007/s10126-022-10106-2. Online ahead of print
Epub:
Yes
Abstract:
Primordial germ cells (PGCs) play an important role in sexual fate determination and gonadal development in gonochoristic fish...
Link:
https://link.springer.com/article/10.1007/s10126-022-10106-2
Delivery Method:
microinjection
Organism or Cell Type:
Monopterus albus (rice field eel)
Citation Extract:
Hou M, Feng K, Luo H, Jiang Y, Xu W, Li Y, Song Y, Chen J, Tao B, Zhu Z, Hu W. Complete Depletion of Primordial Germ Cells Results in Masculinization of Monopterus albus, a Protogynous Hermaphroditic Fish. Mar Biotechnol (NY). 2022 Mar 18. doi: 10.1007/s10126-022-10106-2. Online ahead of print.

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis

Authors:
Haraoka Y, Akieda Y, Nagai Y, Mogi C, Ishitani T
Citation:
Nat Commun. 2022;13(1):1417. doi:10.1038/s41467-022-29061-6
Epub:
Not Epub
Abstract:
Most tumours are thought to arise through oncogenic cell generation followed by additional mutations. How a new oncogenic cell...
Link:
https://www.nature.com/articles/s41467-022-29061-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Haraoka Y, Akieda Y, Nagai Y, Mogi C, Ishitani T. Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nat Commun. 2022;13(1):1417. doi:10.1038/s41467-022-29061-6.

Heat shock induces premature transcript termination and reconfigures the human transcriptome

Authors:
Cugusi S, Mitter R, Kelly GP, Walker J, Han Z, Pisano P, Wierer M, Stewart A, Svejstrup JQ
Citation:
Mol Cell. 2022;[Epub] doi:10.1016/j.molcel.2022.01.007
Epub:
Yes
Abstract:
The heat shock (HS) response involves rapid induction of HS genes, whereas transcriptional repression is established more...
Link:
https://www.sciencedirect.com/science/article/pii/S1097276522000077
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Cugusi S, Mitter R, Kelly GP, Walker J, Han Z, Pisano P, Wierer M, Stewart A, Svejstrup JQ. Heat shock induces premature transcript termination and reconfigures the human transcriptome. Mol Cell. 2022;[Epub] doi:10.1016/j.molcel.2022.01.007.

Sea anemone Frizzled receptors play partially redundant roles in the oral-aboral axis patterning

Authors:
Niedermoser I, Lebedeva T, Genikhovich G
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.03.15.484449
Epub:
Not Epub
Abstract:
Canonical Wnt (cWnt) signaling is involved in a plethora of basic developmental processes such as endomesoderm specification,...
Link:
https://www.biorxiv.org/content/10.1101/2022.03.15.484449v1
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Niedermoser I, Lebedeva T, Genikhovich G. Sea anemone Frizzled receptors play partially redundant roles in the oral-aboral axis patterning. bioRxiv. 2022;[preprint] doi:10.1101/2022.03.15.484449 .

Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model

Authors:
Zheng S, Tang D, Wang X, Liu C, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S
Citation:
Front Mol Neurosci. 2022;15:844568. doi:10.3389/fnmol.2022.844568
Epub:
Not Epub
Abstract:
Kif15, a kinesin family member, is powerful in the formation of bipolar spindles. There is emerging evidence indicating that...
Link:
https://www.frontiersin.org/articles/10.3389/fnmol.2022.844568/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng S, Tang D, Wang X, Liu C, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S. Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model. Front Mol Neurosci. 2022;15:844568. doi:10.3389/fnmol.2022.844568.

Splicing is an alternate oncogenic pathway activation mechanism in glioma

Authors:
Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C
Citation:
Nat Commun. 2022 Jan 31;13(1):588. doi: 10.1038/s41467-022-28253-4
Epub:
Not Epub
Abstract:
High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the genetic drivers of HGG have been well...
Link:
https://www.nature.com/articles/s41467-022-28253-4
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: U87 GBM, pediatric and adult HGG cells
Citation Extract:
Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C. Splicing is an alternate oncogenic pathway activation mechanism in glioma. Nat Commun. 2022 Jan 31;13(1):588. doi: 10.1038/s41467-022-28253-4.

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Authors:
Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R
Citation:
Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434
Epub:
Not Epub
Abstract:
Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub)...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00161-9
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
C57BL/6 or BALB/c mice
Citation Extract:
Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434.

MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes

Authors:
Zhang L, Wang L, Hu X-B, Hou M, Xiao Y, Xiang J-W, Xie J, Chen Z-G, Yang T-H, Nie Q, Fu J-L, Wang Y, Zheng S-Y, Liu Y-F, Gan Y-W, Gao Q, Bai Y-Y, Wang J-M, Qi R-L, Zou M, Ke Q, Zhu X-F, Gong L, Liu Y, Li DW-C
Citation:
Adv Sci. 2022;21o5539 doi:10.1002/advs.20210553
Epub:
Not Epub
Abstract:
The methyltransferase EZH2 plays an important role in regulating chromatin conformation and gene transcription. Phosphorylation...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202105539
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang L, Wang L, Hu X-B, Hou M, Xiao Y, Xiang J-W, Xie J, Chen Z-G, Yang T-H, Nie Q, Fu J-L, Wang Y, Zheng S-Y, Liu Y-F, Gan Y-W, Gao Q, Bai Y-Y, Wang J-M, Qi R-L, Zou M, Ke Q, Zhu X-F, Gong L, Liu Y, Li DW-C. MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes. Adv Sci. 2022;21o5539 doi:10.1002/advs.20210553.

Quantitative Analysis of Transcriptome Dynamics Provides Novel Insights into Developmental State Transitions

Authors:
Johnson K, Freedman S, Braun R, LaBonne C
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.03.10.483850
Epub:
Not Epub
Abstract:
During embryogenesis, the developmental potential of initially pluripotent cells becomes progressively restricted as they...
Link:
https://www.biorxiv.org/content/10.1101/2022.03.10.483850v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Johnson K, Freedman S, Braun R, LaBonne C. Quantitative Analysis of Transcriptome Dynamics Provides Novel Insights into Developmental State Transitions. bioRxiv. 2022;[preprint] doi:10.1101/2022.03.10.483850.

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