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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Authors:
Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B
Citation:
Nat Genet. 2021 Dec 13. doi: 10.1038/s41588-021-00970-4. Online ahead of print
Epub:
Yes
Abstract:
The vertebrate left-right axis is specified during embryogenesis by a transient organ: the left-right organizer (LRO). Species...
Link:
https://www.nature.com/articles/s41588-021-00970-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nat Genet. 2021 Dec 13. doi: 10.1038/s41588-021-00970-4. Online ahead of print.

FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish

Authors:
Xu G, Huang Z, Sheng J, Gao X, Xin W, Garcia JQ, Wei G, Liu D, Gong J
Citation:
Exp Neurol. 2021 Dec 8:113944. doi: 10.1016/j.expneurol.2021.113944. Online ahead of print
Epub:
Yes
Abstract:
Fibroblast growth factor binding protein 3 (Fgfbp3) have been known to be crucial for the process of neural proliferation,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0014488621003526
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu G, Huang Z, Sheng J, Gao X, Xin W, Garcia JQ, Wei G, Liu D, Gong J. FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol. 2021 Dec 8:113944. doi: 10.1016/j.expneurol.2021.113944. Online ahead of print.

miR-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development

Authors:
Konrad KD, Song JL
Citation:
bioRxiv. 2021;[preprint]. doi:10.1101/2021.12.10.471989
Epub:
Not Epub
Abstract:
MicroRNAs (miRNAs) regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The...
Link:
https://www.biorxiv.org/content/10.1101/2021.12.10.471989v1
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Konrad KD, Song JL. miR-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development. bioRxiv. 2021;[preprint]. doi:10.1101/2021.12.10.471989.

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

Authors:
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo W-T, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E
Citation:
Science. 2021;374(6573):eabk0410. doi:10.1126/science.abk0410
Epub:
Not Epub
Abstract:
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting...
Link:
https://www.science.org/doi/epdf/10.1126/science.abk0410
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo W-T, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science. 2021;374(6573):eabk0410. doi:10.1126/science.abk0410.

KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

Authors:
Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J
Citation:
Nat Commun. 2021;12:7180. doi:10.1038/s41467-021-27513-z
Epub:
Not Epub
Abstract:
Metastasis is the main cause of carcinoma-related death, yet we know little about how it initiates due to our inability to...
Link:
https://www.nature.com/articles/s41467-021-27513-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J. KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion. Nat Commun. 2021;12:7180. doi:10.1038/s41467-021-27513-z.

PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans

Authors:
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M
Citation:
Nat Med. 2021:[Epub ahead of print]. doi:10.1038/s41591-021-01572-7
Epub:
Yes
Abstract:
Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset disease that often causes death or severe...
Link:
https://www.nature.com/articles/s41591-021-01572-7
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nat Med. 2021:[Epub ahead of print]. doi:10.1038/s41591-021-01572-7.

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy

Authors:
Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Boukens BJD, de Jonge B, Onderwater YL, van Alebeek E, Chocron S, Polidoro Pontalti C, Weuring WJ, Vos MA, de Boer TP, van Veen TAB, Bakkers J
Citation:
Nat Commun. 2021;12(1):7151. doi:10.1038/s41467-021-27461-8
Epub:
Not Epub
Abstract:
The heterozygous Phospholamban p.Arg14del mutation is found in patients with dilated or arrhythmogenic cardiomyopathy. This...
Link:
https://www.nature.com/articles/s41467-021-27461-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Boukens BJD, de Jonge B, Onderwater YL, van Alebeek E, Chocron S, Polidoro Pontalti C, Weuring WJ, Vos MA, de Boer TP, van Veen TAB, Bakkers J. Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Nat Commun. 2021;12(1):7151. doi:10.1038/s41467-021-27461-8.

Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology

Authors:
Mahabaleshwar H, Asharani PV, Loo TYJ, Koh SY, Pitman MR, Kwok S, Ma J, Hu B, Lin F, Lok XL, Pitson SM, Saunders TE, Carney TJ
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.07.471519
Epub:
Not Epub
Abstract:
Immigration of mesenchymal cells into the growing fin and limb buds drives distal outgrowth, with subsequent tensile forces...
Link:
https://www.biorxiv.org/content/10.1101/2021.12.07.471519v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mahabaleshwar H, Asharani PV, Loo TYJ, Koh SY, Pitman MR, Kwok S, Ma J, Hu B, Lin F, Lok XL, Pitson SM, Saunders TE, Carney TJ. Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.07.471519.

Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

Authors:
Kenjo E, Hozumi H, Makita Y, Iwabuchi KA, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A
Citation:
Nat Commun. 2021;12(1):7101. doi:10.1038/s41467-021-26714-w
Epub:
Not Epub
Abstract:
Genome editing therapy for Duchenne muscular dystrophy (DMD) holds great promise, however, one major obstacle is delivery of...
Link:
https://www.nature.com/articles/s41467-021-26714-w
Delivery Method:
i.m. injection
Organism or Cell Type:
mice
Citation Extract:
Kenjo E, Hozumi H, Makita Y, Iwabuchi KA, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021;12(1):7101. doi:10.1038/s41467-021-26714-w.

Collective durotaxis along a self-generated stiffness gradient in vivo

Authors:
Shellard A, Mayor R
Citation:
Nature. 2021;[Epub ahead of print]. doi:10.1038/s41586-021-04210-x
Epub:
Not Epub
Abstract:
Collective cell migration underlies morphogenesis, wound healing and cancer invasion. Most directed migration in vivo has been...
Link:
https://www.nature.com/articles/s41586-021-04210-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Shellard A, Mayor R. Collective durotaxis along a self-generated stiffness gradient in vivo. Nature. 2021;[Epub ahead of print]. doi:10.1038/s41586-021-04210-x.

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