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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency

Authors:
Diofano F, Weinmann K, Schneider I, Thiessen KD, Rottbauer W, Just S
Citation:
PLoS Genet. 2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088. eCollection 2020 Nov
Epub:
Not Epub
Abstract:
Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM),...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Diofano F, Weinmann K, Schneider I, Thiessen KD, Rottbauer W, Just S. Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency. PLoS Genet. 2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088. eCollection 2020 Nov.

TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

Authors:
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Gabriele Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.27.356782
Epub:
Not Epub
Abstract:
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5’ mono-methylguanosine cap of snRNAs to a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Gabriele Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD. TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.27.356782.

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

Authors:
Reis AH, Sokol SY
Citation:
bioRxiv. 2020;[preprint] doi:/10.1101/2020.10.30.362541
Epub:
Not Epub
Abstract:
The Wnt pathway activates target genes by controlling the b-catenin-T-cell factor (TCF) transcriptional complex during...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Reis AH, Sokol SY. Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. bioRxiv. 2020;[preprint] doi:/10.1101/2020.10.30.362541 .

Uncovering the mesendoderm gene regulatory network through multi-omic data integration

Authors:
Jansen C, Paraiso K, Zhou J, Blitz IL, Fish M, Charney R, Cho JS, Yasuoka Y, Sudou N, Bright AR, Wlizla M, Veenstra GJC, Taira M, Zorn A, Mortazavi A, Cho KWY
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.01.362053
Epub:
Not Epub
Abstract:
Mesendodermal specification is one of the earliest events in embryogenesis, where cells first acquire distinct identities. Cell...
Organism or Cell Type:
Xenopus
Citation Extract:
Jansen C, Paraiso K, Zhou J, Blitz IL, Fish M, Charney R, Cho JS, Yasuoka Y, Sudou N, Bright AR, Wlizla M, Veenstra GJC, Taira M, Zorn A, Mortazavi A, Cho KWY. Uncovering the mesendoderm gene regulatory network through multi-omic data integration. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.01.362053.

Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish

Authors:
Khandekar G, Iyer N, Jagadeeswaran P
Citation:
Res Pract Thromb Haemost. 2020 Sep 22;4(7):1150-1157. doi: 10.1002/rth2.12428. eCollection 2020 Oct
Epub:
Not Epub
Abstract:
Background: Blood clotting in humans is initiated by the binding of tissue factor to activated coagulation factor VII (FVIIa)...
Delivery Method:
Vivo-Morpholino (piggyback)
Organism or Cell Type:
zebrafish
Citation Extract:
Khandekar G, Iyer N, Jagadeeswaran P. Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish. Res Pract Thromb Haemost. 2020 Sep 22;4(7):1150-1157. doi: 10.1002/rth2.12428. eCollection 2020 Oct.

Influence of astrocytic glutamine transporter SN1 deficiency on electrophysiological correlates of glutamatergic transmission

Authors:
Popek M, Bobula B, Sowa J, Hess G, Albrecht J, Zielinska M
Citation:
J Neurochem. 2017; 142(suppl 1):125. doi:10.1111/jnc.14093
Epub:
Not Epub
Abstract:
The N-system glutamine transporter SN1 preferentially transfers glutamine out of astrocytes (Chaudhry et al., Cell 1999), and...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Popek M, Bobula B, Sowa J, Hess G, Albrecht J, Zielinska M. Influence of astrocytic glutamine transporter SN1 deficiency on electrophysiological correlates of glutamatergic transmission. J Neurochem. 2017; 142(suppl 1):125. doi:10.1111/jnc.14093.

Phosphatidylinositol 4 kinase-β mutations cause non-syndromic sensorineural deafness and inner ear malformation

Authors:
Su X, Feng Y, Rahman SA, Wu S, Li G, Rüschendorf F, Zhao L, Cui H, Liang J, Fang L, Hu H, Froehler S, Yu Y, Patone G, Hummel O, Chen Q, Raile K, Luft FC, Bähring S, Hussain K, Chen W, Zhang J, Gong
Citation:
J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2020.07.008
Epub:
Yes
Abstract:
Congenital hearing loss is a common disorder worldwide. Heterogeneous gene variation accounts for approximately 20% - 25% of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Su X, Feng Y, Rahman SA, Wu S, Li G, Rüschendorf F, Zhao L, Cui H, Liang J, Fang L, Hu H, Froehler S, Yu Y, Patone G, Hummel O, Chen Q, Raile K, Luft FC, Bähring S, Hussain K, Chen W, Zhang J, Gong. Phosphatidylinositol 4 kinase-β mutations cause non-syndromic sensorineural deafness and inner ear malformation. J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2020.07.008.

Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis

Authors:
Won SY, Kwon S, Jeong HS, Chung KW, Choi BO, Chang JW, Lee JE
Citation:
Stem Cells. 2020 Oct 27. doi: 10.1002/stem.3287. Online ahead of print
Epub:
Yes
Abstract:
In the peripheral nervous system (PNS), proper development of Schwann cells (SCs) contributing to axonal myelination is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Won SY, Kwon S, Jeong HS, Chung KW, Choi BO, Chang JW, Lee JE. Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis. Stem Cells. 2020 Oct 27. doi: 10.1002/stem.3287. Online ahead of print.

Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition

Authors:
Kinney BA, Anber AA, Row RH, Tseng Y-J, Weidmann MD, Knaut H, Martin BL
Citation:
Cell Rep. 2020;33(4):108311. doi:10.1016/j.celrep.2020.108311
Epub:
Not Epub
Abstract:
Animal embryogenesis requires a precise coordination between morphogenesis and cell fate specification. During mesoderm...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kinney BA, Anber AA, Row RH, Tseng Y-J, Weidmann MD, Knaut H, Martin BL. Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition. Cell Rep. 2020;33(4):108311. doi:10.1016/j.celrep.2020.108311.

GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons

Authors:
Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani M, Kato TA, Ishitani T, Kato H, Masuda K, Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S
Citation:
FASEB J. 2020 Oct 27;[Epub ahead of print] doi:10.1096/fj.202001113R. Online ahead of print
Epub:
Yes
Abstract:
Developmental and epileptic encephalopathy (DEE) represents a group of neurodevelopmental disorders characterized by infantile‐...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani M, Kato TA, Ishitani T, Kato H, Masuda K, Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S. GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons. FASEB J. 2020 Oct 27;[Epub ahead of print] doi:10.1096/fj.202001113R. Online ahead of print.

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