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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing

Authors:
Schürch C, Schaefer T, Müller JS, Hanns P, Arnone M, Dumlin A, Schärer J, Sinning I, Wild K, Skokowa J, Welte K, Carapito R, Bahram S, Konantz M, Lengerke C
Citation:
Blood (2021) 137 (10): 1340–1352. doi:10.1182/blood.2020008115
Epub:
Not Epub
Abstract:
Heterozygous de novo missense variants of SRP54 were recently identified in patients with congenital neutropenia (CN),...
Link:
https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2020008115/474249/SRP54-mutations-induce-Congenital-Neutropenia-via
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schürch C, Schaefer T, Müller JS, Hanns P, Arnone M, Dumlin A, Schärer J, Sinning I, Wild K, Skokowa J, Welte K, Carapito R, Bahram S, Konantz M, Lengerke C. SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing. Blood (2021) 137 (10): 1340–1352. doi:10.1182/blood.2020008115.

Striatal astrocytes shape behavioral flexibility via regulation of the glutamate transporter EAAT2

Authors:
Boender AJ, Bontempi L, Nava L, Pelloux Y, Tonini R
Citation:
Biol Psychiatry. 2020;[Epub ahead of print] doi:10.1016/j.biopsych.2020.11.015
Epub:
Yes
Abstract:
Background: Striatal circuits must be modulated for behavioral flexibility – the ability to adapt to environmental changes....
Link:
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(20)32076-X/fulltext
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Boender AJ, Bontempi L, Nava L, Pelloux Y, Tonini R. Striatal astrocytes shape behavioral flexibility via regulation of the glutamate transporter EAAT2. Biol Psychiatry. 2020;[Epub ahead of print] doi:10.1016/j.biopsych.2020.11.015.

STAT3 inhibits Myocardin induced cardiac hypertrophy

Authors:
Liao X-H, Xiang Y, Li J-P, Li H, Huang Y, Shen C, Zhang Z, Zhang T-C
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.21.392902
Epub:
Not Epub
Abstract:
Background: In order to explore the molecular mechanism of cardiomyocyte-dependent myocardial gene expression and cardiomyocyte...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.21.392902v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liao X-H, Xiang Y, Li J-P, Li H, Huang Y, Shen C, Zhang Z, Zhang T-C. STAT3 inhibits Myocardin induced cardiac hypertrophy. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.21.392902 .

Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion

Authors:
Slováková J, Sikora M, Caballero-Mancebo S, Krens SFG, Kaufmann WA, Huljev K, Heisenberg C-P
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.20.391284
Epub:
Not Epub
Abstract:
Tension of the actomyosin cell cortex plays a key role in determining cell-cell contact growth and size. The level of cortical...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.20.391284v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Slováková J, Sikora M, Caballero-Mancebo S, Krens SFG, Kaufmann WA, Huljev K, Heisenberg C-P. Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.20.391284.

Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity

Authors:
Cambier CJ, Banik SM, Buonomo JA, Bertozzi CR
Citation:
eLife. 2020;9:e60648 doi:10.7554/eLife.60648
Epub:
Not Epub
Abstract:
Several virulence lipids populate the outer cell wall of pathogenic mycobacteria (Jackson, 2014). Phthiocerol dimycocerosate (...
Link:
https://elifesciences.org/articles/60648
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cambier CJ, Banik SM, Buonomo JA, Bertozzi CR. Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity. eLife. 2020;9:e60648 doi:10.7554/eLife.60648.

Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells

Authors:
Pak B, Schmitt CE, Choi W, Kim J-D, Han O, Alsiö J, Jung D-W, Williams DR, Coppieters W, Stainier DYR, Jin S-W
Citation:
Front Cell Devel Biol. 2020;8:1306. doi:10.3389/fcell.2020.589717
Epub:
Not Epub
Abstract:
Endothelial cells appear to emerge from diverse progenitors. However, to which extent their developmental origin contributes to...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.589717/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pak B, Schmitt CE, Choi W, Kim J-D, Han O, Alsiö J, Jung D-W, Williams DR, Coppieters W, Stainier DYR, Jin S-W. Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells. Front Cell Devel Biol. 2020;8:1306. doi:10.3389/fcell.2020.589717 .

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Authors:
Xu J, Wan Z, Tang M, Lin Z, Jiang S, Ji L, Gorshkov K, Mao Q, Xia S, Cen D, Zheng J, Liang X, Cai X
Citation:
Mol Cancer. 2020:19(1):163. doi:10.1186/s12943-020-01281-8
Epub:
Not Epub
Abstract:
Background and aims: Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC)...
Link:
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-020-01281-8
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HepG2-SR
Citation Extract:
Xu J, Wan Z, Tang M, Lin Z, Jiang S, Ji L, Gorshkov K, Mao Q, Xia S, Cen D, Zheng J, Liang X, Cai X. N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling. Mol Cancer. 2020:19(1):163. doi:10.1186/s12943-020-01281-8.

Transcriptional regulation of EMT by nuclear MMP28

Authors:
Gouignard N, Bibonne A, Saint-Jeannet J-P, Theveneau E
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.19.389544
Epub:
Not Epub
Abstract:
Epithelial-Mesenchymal Transition (EMT) is an early event in cell dissemination from epithelial tissues. EMT endows cells with...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.19.389544v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gouignard N, Bibonne A, Saint-Jeannet J-P, Theveneau E. Transcriptional regulation of EMT by nuclear MMP28. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.19.389544 .

Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Authors:
Espanola SG, Song H, Ryu E, Saxena A, Kim E-S, Manegold JE, Nasamran CA, Sahoo D, Oh C-K, Bickers C, Shin U, Grainger S, Park YH, Pandolfo L, Kang M-S, Kang S, Myung K, Cooper KL, Yelon D, Traver D, Lee Y
Citation:
Nat Cell Biol. 2020;[Epub ahead of print] doi:10.1038/s41556-020-00604-7
Epub:
Yes
Abstract:
Haematopoietic stem and progenitor cells (HSPCs) have been the focus of developmental and regenerative studies, yet our...
Link:
https://www.nature.com/articles/s41556-020-00604-7
Organism or Cell Type:
zebrafish
Citation Extract:
Espanola SG, Song H, Ryu E, Saxena A, Kim E-S, Manegold JE, Nasamran CA, Sahoo D, Oh C-K, Bickers C, Shin U, Grainger S, Park YH, Pandolfo L, Kang M-S, Kang S, Myung K, Cooper KL, Yelon D, Traver D, Lee Y. Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Nat Cell Biol. 2020;[Epub ahead of print] doi:10.1038/s41556-020-00604-7.

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

Authors:
Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK, Scarduzio M, Wang H, Chang C, Datta PK
Citation:
Nat Comm. 2020;11(1):5941. doi:10.1038/s41467-020-19698-6
Epub:
Not Epub
Abstract:
Alternative splicing (AS) is involved in cell fate decisions and embryonic development. However, regulation of these processes...
Link:
https://www.nature.com/articles/s41467-020-19698-6
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK, Scarduzio M, Wang H, Chang C, Datta PK. STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Nat Comm. 2020;11(1):5941. doi:10.1038/s41467-020-19698-6.

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