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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome

Authors:
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A
Citation:
Nat Genet. 2020;[Epub ahead of print]. doi:10.1038/s41588-020-00724-8
Epub:
Yes
Abstract:
The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin...
Link:
https://www.nature.com/articles/s41588-020-00724-8
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A. MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome. Nat Genet. 2020;[Epub ahead of print]. doi:10.1038/s41588-020-00724-8.

A generic assay for the identification of splicing variants that induce nonsense-mediated decay in Pompe disease

Authors:
Bergsma AJ, in ’t Groen SLM, Catalano F, Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT, Pijnappel WWMP
Citation:
Eur J Hum Genet. 2020;{Epub ahead of print]. doi:10.1038/s41431-020-00751-3
Epub:
Yes
Abstract:
DNA variants affecting mRNA expression and processing in genetic diseases are often missed or poorly characterized. We...
Link:
https://www.nature.com/articles/s41431-020-00751-3
Delivery Method:
Endo-Porter DMSO
Organism or Cell Type:
cell culture: human primary fibroblasts
Citation Extract:
Bergsma AJ, in ’t Groen SLM, Catalano F, Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT, Pijnappel WWMP. A generic assay for the identification of splicing variants that induce nonsense-mediated decay in Pompe disease. Eur J Hum Genet. 2020;{Epub ahead of print]. doi:10.1038/s41431-020-00751-3.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers

Authors:
Rosenke K, Leventhal S, Moulton HM, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
J Antimicrob Chemother. 2021 Jan 19;76(2):413-417. doi: 10.1093/jac/dkaa460. PMID: 33164048; PMCID: PMC7717290
Epub:
Yes
Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7717290/
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton HM, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers. J Antimicrob Chemother. 2021 Jan 19;76(2):413-417. doi: 10.1093/jac/dkaa460. PMID: 33164048; PMCID: PMC7717290.

Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells

Authors:
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón N-A, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E
Citation:
Immunity. 2020;[Epub ahead of print] doi:10.1016/j.immuni.2020.10.007
Epub:
Yes
Abstract:
Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC) development. Here, we studied the...
Link:
https://www.cell.com/immunity/pdf/S1074-7613(20)30448-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón N-A, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E. Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 2020;[Epub ahead of print] doi:10.1016/j.immuni.2020.10.007.

Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos

Authors:
Ketharnathan S, Labudina A, Horsfield JA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.19.346122
Epub:
Not Epub
Abstract:
Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3 and Rad21, and either Stag1 or Stag2. Normal...
Link:
https://www.biorxiv.org/content/10.1101/2020.10.19.346122v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ketharnathan S, Labudina A, Horsfield JA. Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.19.346122.

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification

Authors:
Hutchins EJ, Chacon J, Bronner ME
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.14.338715
Epub:
Not Epub
Abstract:
Neural crest development is transcriptionally controlled via sequential activation of gene regulatory networks (GRNs). Recent...
Link:
https://www.biorxiv.org/content/10.1101/2020.10.14.338715v1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Hutchins EJ, Chacon J, Bronner ME. RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.14.338715 .

hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development

Authors:
Ye Z, Kimelman D
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.185298
Epub:
Yes
Abstract:
The early vertebrate embryo extends from anterior to posterior due to the addition of neural and mesodermal cells from a...
Link:
https://dev.biologists.org/content/early/2020/11/03/dev.185298
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ye Z, Kimelman D. hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development. 2020;[Epub ahead of print] doi:10.1242/dev.185298.

Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model

Authors:
Arogbokun O, Shevik M, Slusher T, Farouk Z, Elfstrum A, Weber J, Cusick SE, Lund T
Citation:
Sci Rep. 2020;10(1):19172 doi:10.1038/s41598-020-75823-x
Epub:
Not Epub
Abstract:
Traditional remedies are widely used throughout Africa in routine care for infants. However, such remedies could have...
Link:
https://www.nature.com/articles/s41598-020-75823-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arogbokun O, Shevik M, Slusher T, Farouk Z, Elfstrum A, Weber J, Cusick SE, Lund T. Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Sci Rep. 2020;10(1):19172 doi:10.1038/s41598-020-75823-x.

A serpin is required for ectomesoderm, a hallmark of spiralian development

Authors:
Wu L, Lambert JD
Citation:
Dev Biol. 2020 Oct 24:S0012-1606(20)30282-7. doi: 10.1016/j.ydbio.2020.10.011. Online ahead of print
Epub:
Yes
Abstract:
Among animals, diploblasts contain two germ layers, endoderm and ectoderm, while triploblasts have a distinct third germ layer...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620302827
Delivery Method:
microinjection
Organism or Cell Type:
Tritia obsoleta (previously Ilyanassa obsoleta) gastropod
Citation Extract:
Wu L, Lambert JD. A serpin is required for ectomesoderm, a hallmark of spiralian development. Dev Biol. 2020 Oct 24:S0012-1606(20)30282-7. doi: 10.1016/j.ydbio.2020.10.011. Online ahead of print.

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

Authors:
Lee H, Seidl C, Sun R, Glinka A, Niehrs C
Citation:
Nat Commun. 2020;11:5570. doi:10.1038/s41467-020-19373-w
Epub:
Not Epub
Abstract:
BMP signaling plays key roles in development, stem cells, adult tissue homeostasis, and disease. How BMP receptors are...
Link:
https://www.nature.com/articles/s41467-020-19373-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H, Seidl C, Sun R, Glinka A, Niehrs C. R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun. 2020;11:5570. doi:10.1038/s41467-020-19373-w.

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