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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

PDE10A inhibition reduces the manifestation of pathology in DMD zebrafish and represses the genetic modifier PITPNA

Authors:
Lambert MR, Spinazzola JM, Widrick JJ, Pakula A, Conner JR, Chin JE, Owens JM, Kunkel LM
Citation:
Mol Ther. 2020;[Epub ahead of print] doi:10.1016/j.ymthe.2020.11.021
Epub:
Yes
Abstract:
Duchenne Muscular Dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene. Absence of dystrophin...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30619-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lambert MR, Spinazzola JM, Widrick JJ, Pakula A, Conner JR, Chin JE, Owens JM, Kunkel LM. PDE10A inhibition reduces the manifestation of pathology in DMD zebrafish and represses the genetic modifier PITPNA. Mol Ther. 2020;[Epub ahead of print] doi:10.1016/j.ymthe.2020.11.021.

The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network

Authors:
Grocott T, Lozano-Velasco E, Mok GF, Münsterberg AE
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.185827
Epub:
Yes
Abstract:
\Understanding how complex organ systems are assembled from simple embryonic tissues is a major challenge. Across the animal...
Link:
https://dev.biologists.org/content/early/2020/11/15/dev.185827
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: Gallus gallus (chick) somite tissue
Citation Extract:
Grocott T, Lozano-Velasco E, Mok GF, Münsterberg AE. The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network. Development. 2020;[Epub ahead of print] doi:10.1242/dev.185827.

Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis

Authors:
Huang X, Zhang L, Yang S, Zhang Y, Wu M, Chen P
Citation:
Genes. 2020:11(11):2073-4425. doi:10.3390/genes11111363
Epub:
Not Epub
Abstract:
Gastrulation drives the establishment of three germ layers and embryonic axes during frog embryonic development. Mesodermal...
Link:
https://www.mdpi.com/2073-4425/11/11/1363/htm
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Huang X, Zhang L, Yang S, Zhang Y, Wu M, Chen P. Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis. Genes. 2020:11(11):2073-4425. doi:10.3390/genes11111363.

Antagonistic activities of Fmn2 and ADF regulate axonal F-actin patch dynamics and the initiation of collateral branching

Authors:
Kundu T, Das SS, Kumar DS, Sewatkar LK, Ghose A
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.16.384099
Epub:
Not Epub
Abstract:
Interstitial collateral branching of axons is a critical component in the development of functional neural circuits. Axon...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.16.384099v1
Organism or Cell Type:
cell culture: chick spinal neurons
Citation Extract:
Kundu T, Das SS, Kumar DS, Sewatkar LK, Ghose A. Antagonistic activities of Fmn2 and ADF regulate axonal F-actin patch dynamics and the initiation of collateral branching. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.16.384099.

PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

Authors:
Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, Sawa A, Wetsel WC, Werge T, Katsanis N
Citation:
Nat Comm. 2020;11:5903. doi:10.1038/s41467-020-19637-5
Epub:
Not Epub
Abstract:
The neuronal primary cilium and centriolar satellites have functions in neurogenesis, but little is known about their roles in...
Link:
https://www.nature.com/articles/s41467-020-19637-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, Sawa A, Wetsel WC, Werge T, Katsanis N. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Nat Comm. 2020;11:5903. doi:10.1038/s41467-020-19637-5.

Tension heterogeneity directs form and fate to pattern the myocardial wall

Authors:
Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein H-M, Stainier DYR
Citation:
Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2946-9
Epub:
Yes
Abstract:
How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the...
Link:
https://www.nature.com/articles/s41586-020-2946-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein H-M, Stainier DYR. Tension heterogeneity directs form and fate to pattern the myocardial wall. Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2946-9.

RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish

Authors:
Raman R, Ryon M, Jagadeeswaran P
Citation:
Sci Rep. 2020;10:20187 doi:10.1038/s41598-020-76655-5
Epub:
Not Epub
Abstract:
We recently developed a piggyback knockdown method that was used to knockdown genes in adult zebrafish. In this method, a vivo...
Link:
https://www.nature.com/articles/s41598-020-76655-5
Delivery Method:
Vivo-Morpholino (piggyback )
Organism or Cell Type:
zebrafish
Citation Extract:
Raman R, Ryon M, Jagadeeswaran P. RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Sci Rep. 2020;10:20187 doi:10.1038/s41598-020-76655-5.

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

Authors:
Parshina EA, Eroshkin FM, Оrlov EE, Gyoeva FK, Shokhina AG, Staroverov DB, Belousov VV, Zhigalova NA, Prokhortchouk EB, Zaraisky AG, Martynova NY
Citation:
Cell Rep. 2020;33(7):108396. doi:10.1016/j.celrep.2020.108396
Epub:
Not Epub
Abstract:
Zyxin is a cytoskeletal LIM-domain protein that regulates actin cytoskeleton assembly and gene expression. In the present work...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31385-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis and zebrafish
Citation Extract:
Parshina EA, Eroshkin FM, Оrlov EE, Gyoeva FK, Shokhina AG, Staroverov DB, Belousov VV, Zhigalova NA, Prokhortchouk EB, Zaraisky AG, Martynova NY. Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status. Cell Rep. 2020;33(7):108396. doi:10.1016/j.celrep.2020.108396.

Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression

Authors:
Wu CS, Lu YF, Liu YH, Huang CJ, Hwang SL
Citation:
Dev Biol. 2020 Nov 13:S0012-1606(20)30293-1. doi: 10.1016/j.ydbio.2020.11.001. Online ahead of print
Epub:
Yes
Abstract:
Nodal signaling is essential for mesoderm and endoderm formation, as well as neural plate induction and establishment of left-...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160620302931
Delivery Method:
microinjection, Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Wu CS, Lu YF, Liu YH, Huang CJ, Hwang SL. Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression. Dev Biol. 2020 Nov 13:S0012-1606(20)30293-1. doi: 10.1016/j.ydbio.2020.11.001. Online ahead of print.

GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base

Authors:
Jang DG, Kwon KY, Kweon YC, Kim B-g, Myung K, Lee H-S, Park CY, Kwon T, Park TJ
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.13.381764
Epub:
Not Epub
Abstract:
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction...
Link:
https://www.biorxiv.org/content/10.1101/2020.11.13.381764v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Jang DG, Kwon KY, Kweon YC, Kim B-g, Myung K, Lee H-S, Park CY, Kwon T, Park TJ. GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.13.381764 .

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