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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning

Authors:
Amiel AR, Johnston H, Chock T, Dahlin P, Iglesias M, Layden M, Röttinger E, Martindale MQ
Citation:
Dev Biol. 2017 Oct 15;430(2):346-361. doi: 10.1016/j.ydbio.2017.08.015. Epub 2017 Aug 14
Epub:
Not Epub
Abstract:
Germ layer formation and axial patterning are biological processes that are tightly linked during embryonic development of most...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160617302804
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Amiel AR, Johnston H, Chock T, Dahlin P, Iglesias M, Layden M, Röttinger E, Martindale MQ. A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning. Dev Biol. 2017 Oct 15;430(2):346-361. doi: 10.1016/j.ydbio.2017.08.015. Epub 2017 Aug 14.

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Authors:
Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F
Citation:
Lancet. 2011 Aug 13;378(9791):595-605. doi: 10.1016/S0140-6736(11)60756-3. Epub 2011 Jul 23
Epub:
Not Epub
Abstract:
BACKGROUND: We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658...
Link:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60756-3/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. Lancet. 2011 Aug 13;378(9791):595-605. doi: 10.1016/S0140-6736(11)60756-3. Epub 2011 Jul 23.

Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

Authors:
Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng X-XI, Groff M, Kasper Wang K, Parsons MJ, Crump JG, Dong PDS
Citation:
Nat Comm. 2017;8:769. doi:10.1038/s41467-017-00666-6
Epub:
Not Epub
Abstract:
Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1...
Link:
https://www.nature.com/articles/s41467-017-00666-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng X-XI, Groff M, Kasper Wang K, Parsons MJ, Crump JG, Dong PDS. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Comm. 2017;8:769. doi:10.1038/s41467-017-00666-6.

U1 snRNP telescripting regulates a size-function-stratified human genome

Authors:
Oh JM, Di C, Venters CC, Guo J, Arai C, So BR, Pinto AM, Zhang Z, Wan L, Younis I, Dreyfuss G
Citation:
Nat Struct Mol Biol. 2017 Oct 2. doi: 10.1038/nsmb.3473. [Epub ahead of print]
Epub:
Yes
Abstract:
U1 snRNP (U1) functions in splicing introns and telescripting, which suppresses premature cleavage and polyadenylation (PCPA)....
Link:
https://www.nature.com/nsmb/journal/vaop/ncurrent/full/nsmb.3473.html
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Oh JM, Di C, Venters CC, Guo J, Arai C, So BR, Pinto AM, Zhang Z, Wan L, Younis I, Dreyfuss G. U1 snRNP telescripting regulates a size-function-stratified human genome. Nat Struct Mol Biol. 2017 Oct 2. doi: 10.1038/nsmb.3473. [Epub ahead of print].

Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice

Authors:
Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M
Citation:
J Drug Target. 2017 Oct 3:1-34. doi: 10.1080/1061186X.2017.1387789. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a class of antisense oligonucleotides used in the treatment of...
Link:
http://www.tandfonline.com/doi/abs/10.1080/1061186X.2017.1387789
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. J Drug Target. 2017 Oct 3:1-34. doi: 10.1080/1061186X.2017.1387789. [Epub ahead of print].

PRAJA is overexpressed in glioblastoma and contributes to neural precursor development

Authors:
Shin J, Mishra V, Glasgow E, Zaidi S, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B
Citation:
Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151
Epub:
Not Epub
Abstract:
PRAJA, a RING-H2 E3 ligase, is abundantly expressed in brain tissues such as the cerebellum and frontal cortex, amongst others...
Link:
http://www.impactjournals.com/Genes&Cancer/index.php?pii=151
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shin J, Mishra V, Glasgow E, Zaidi S, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B. PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151.

Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

Authors:
Shi Z, Yang X, Li BB, Chen S, Yang L, Cheng L, Zhang T, Wang H, Zheng Y
Citation:
Birth Defects Res. 2017 Sep 29. doi: 10.1002/bdr2.1122. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Neural tube defects (NTDs), the second most frequent cause of human congenital abnormalities, are debilitating...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/bdr2.1122/abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Shi Z, Yang X, Li BB, Chen S, Yang L, Cheng L, Zhang T, Wang H, Zheng Y . Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects. Birth Defects Res. 2017 Sep 29. doi: 10.1002/bdr2.1122. [Epub ahead of print].

Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes

Authors:
Riddiford N, Schlosser G
Citation:
Dev Biol. 2017 Sep 22. pii: S0012-1606(17)30412-8. doi: 10.1016/j.ydbio.2017.09.027. [Epub ahead of print]
Epub:
Yes
Abstract:
The transcription factor Six1 and its cofactor Eya1 are important regulators of neurogenesis in cranial placodes, activating...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160617304128
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Riddiford N, Schlosser G. Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes. Dev Biol. 2017 Sep 22. pii: S0012-1606(17)30412-8. doi: 10.1016/j.ydbio.2017.09.027. [Epub ahead of print].

LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells

Authors:
Choi HJ, Rho SS, Choi DH, Kwon YG
Citation:
BMB Rep. 2017 Sep 26. pii: 3929. [Epub ahead of print]
Epub:
Yes
Abstract:
Delta-like ligand 4 (DLL4) expression in endothelial cells is intimately associated with angiogenic sprouting and vascular...
Link:
http://submit.bmbreports.org/Search/View.html?tmp_tr_num=3929
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Choi HJ, Rho SS, Choi DH, Kwon YG. LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. BMB Rep. 2017 Sep 26. pii: 3929. [Epub ahead of print].

Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis

Authors:
Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi Q, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H, Liu F, Zhao J
Citation:
Blood. 2017;[Epub ahead of print] doi:10.1182/blood-2017-05-783043
Epub:
Yes
Abstract:
Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases and is often accompanied by anemia and...
Link:
http://www.bloodjournal.org/content/early/2017/09/22/blood-2017-05-783043
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi Q, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H, Liu F, Zhao J. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017;[Epub ahead of print] doi:10.1182/blood-2017-05-783043.

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