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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants

Authors:
Pant SD, March LD, Famulski JK, French CR, Lehmann OJ, Waskiewicz AJ
Citation:
Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5871-9. doi: 10.1167/iovs.12-11315
Epub:
Not Epub
Abstract:
Purpose.: To characterize the molecular mechanisms underlying retinal apoptosis induced by loss of Gdf6, a TGFβ ligand....
Link:
http://iovs.arvojournals.org/article.aspx?articleid=2129025
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pant SD, March LD, Famulski JK, French CR, Lehmann OJ, Waskiewicz AJ. Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants. Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5871-9. doi: 10.1167/iovs.12-11315.

Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling

Authors:
Londin ER, Mentzer L, Sirotkin HI
Citation:
BMC Dev Biol. 2007 Nov 2;7:120
Epub:
Not Epub
Abstract:
BACKGROUND: Cell movements are essential to the determination of cell fates during development. The zinc-finger transcription...
Link:
https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-7-120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Londin ER, Mentzer L, Sirotkin HI. Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. BMC Dev Biol. 2007 Nov 2;7:120.

A splicing mutation in VPS4B causes dentin dysplasia I

Authors:
Yang Q, Chen D, Xiong F, Chen D, Liu C, Liu Y, Yu Q, Xiong J, Liu J, Li K, Zhao L, Ye Y, Zhou H, Hu L, Tian Z, Shang X, Zhang L, Wei X, Zhou W, Li D, Zhang W, Xu X
Citation:
J Med Genet. 2016 Sep;53(9):624-33. doi: 10.1136/jmedgenet-2015-103619
Epub:
Not Epub
Abstract:
BACKGROUND: Dentin dysplasia I (DDI) is a genetically heterogeneous autosomal-dominant disorder characterised by rootless teeth...
Link:
http://jmg.bmj.com/content/53/9/624
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Q, Chen D, Xiong F, Chen D, Liu C, Liu Y, Yu Q, Xiong J, Liu J, Li K, Zhao L, Ye Y, Zhou H, Hu L, Tian Z, Shang X, Zhang L, Wei X, Zhou W, Li D, Zhang W, Xu X . A splicing mutation in VPS4B causes dentin dysplasia I. J Med Genet. 2016 Sep;53(9):624-33. doi: 10.1136/jmedgenet-2015-103619.

GATA5 SUMOylation is indispensable for zebrafish cardiac development

Authors:
Wen B, Yuan H, Liu X, Wang H, Chen S, Chen Z, de The H, Zhou J, Zhu J
Citation:
Biochim Biophys Acta. 2017 Mar 8. pii: S0304-4165(17)30088-0. doi: 10.1016/j.bbagen.2017.03.005. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: SUMOylation is a critical regulatory protein modification in eukaryotic cells and plays a pivotal role in cardiac...
Link:
http://www.sciencedirect.com/science/article/pii/S0304416517300880
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wen B, Yuan H, Liu X, Wang H, Chen S, Chen Z, de The H, Zhou J, Zhu J. GATA5 SUMOylation is indispensable for zebrafish cardiac development. Biochim Biophys Acta. 2017 Mar 8. pii: S0304-4165(17)30088-0. doi: 10.1016/j.bbagen.2017.03.005. [Epub ahead of print].

Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes

Authors:
Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM
Citation:
Genome Biol. 2017 Mar 8;18(1):48. doi: 10.1186/s13059-017-1174-6
Epub:
Not Epub
Abstract:
BACKGROUND: Hirschsprung disease (HSCR), which is congenital obstruction of the bowel, results from a failure of enteric...
Link:
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1174-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome Biol. 2017 Mar 8;18(1):48. doi: 10.1186/s13059-017-1174-6.

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells

Authors:
Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ
Citation:
Angiogenesis. 2017 Mar 7. doi: 10.1007/s10456-017-9542-0. [Epub ahead of print]
Epub:
Yes
Abstract:
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two...
Link:
http://link.springer.com/article/10.1007%2Fs10456-017-9542-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ. RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 2017 Mar 7. doi: 10.1007/s10456-017-9542-0. [Epub ahead of print].

Troponin-I is present as an essential component of muscles in echinoderm larvae

Authors:
Yaguchi S, Yaguchi J, Tanaka H
Citation:
Sci Rep. 2017;7:43563. doi:10.1038/srep43563
Epub:
Not Epub
Abstract:
The troponin complex, composed of Troponin-I, Troponin-T and Troponin-C, is an essential mediator of the contraction of...
Link:
http://www.nature.com/articles/srep43563
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi S, Yaguchi J, Tanaka H. Troponin-I is present as an essential component of muscles in echinoderm larvae. Sci Rep. 2017;7:43563. doi:10.1038/srep43563.

Gene Silencing with Morpholinos

Authors:
JoVE Science Education Database
Citation:
JoVE. 2017. doi:10.3791/5326
Epub:
Not Epub
Abstract:
Morpholino-mediated gene silencing is a common technique used to study roles of specific genes during development. Morpholinos...
Link:
https://www.jove.com/science-education/5326/gene-silencing-with-morpholinos
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
JoVE Science Education Database. Gene Silencing with Morpholinos. JoVE. 2017. doi:10.3791/5326.

A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish

Authors:
Lawir D-F, Iwanami N, Schorpp M, Boehm T
Citation:
Sci Rep. 2017;7:44145. doi:10.1038/srep44145
Epub:
Not Epub
Abstract:
T cells are an evolutionarily conserved feature of the adaptive immune systems of vertebrates. Comparative studies using...
Link:
http://www.nature.com/articles/srep44145
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lawir D-F, Iwanami N, Schorpp M, Boehm T. A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. Sci Rep. 2017;7:44145. doi:10.1038/srep44145.

Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia

Authors:
Egunsola AT, Bae Y, Jiang MM, Liu DS, Chen-Evenson Y, Bertin T, Chen S, Lu JT, Nevarez L, Magal N, Raas-Rothschild A, Swindell EC, Cohn DH, Gibbs RA, Campeau PM, Shohat M, Lee BH
Citation:
J Clin Invest. 2017 Mar 6. pii: 90193. doi: 10.1172/JCI90193. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Shohat-type spondyloepimetaphyseal dysplasia (SEMD) is a skeletal dysplasia that affects cartilage development. Similar...
Link:
https://www.jci.org/articles/view/90193
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Egunsola AT, Bae Y, Jiang MM, Liu DS, Chen-Evenson Y, Bertin T, Chen S, Lu JT, Nevarez L, Magal N, Raas-Rothschild A, Swindell EC, Cohn DH, Gibbs RA, Campeau PM, Shohat M, Lee BH. Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. J Clin Invest. 2017 Mar 6. pii: 90193. doi: 10.1172/JCI90193. [Epub ahead of print].

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