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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
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Citation:
eLife. 2017;6:e21221 doi:10.7554/eLife.21221 Epub:
Not Epub Abstract:
Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, AB Robertson AAB, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M. Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife. 2017;6:e21221 doi:10.7554/eLife.21221. |
Identification of Mutant Genes and Introgressed Tiger Salamander DNA in the Laboratory Axolotl, Ambystoma mexicanum
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Citation:
Sci Rep. 2017 Dec;7(1):6. doi: 10.1038/s41598-017-00059-1 Epub:
Not Epub Abstract:
The molecular genetic toolkit of the Mexican axolotl, a classic model organism, has matured to the point where it is now... Delivery Method:
microinjection Organism or Cell Type:
Ambystoma mexicanum (Axolotl) Citation Extract: Woodcock MR, Vaughn-Wolfe J, Elias A, Kump DK, Kendall KD, Timoshevskaya N, Timoshevskiy V, Perry DW, Smith JJ, Spiewak JE, Parichy DM, Voss SR. Identification of Mutant Genes and Introgressed Tiger Salamander DNA in the Laboratory Axolotl, Ambystoma mexicanum. Sci Rep. 2017 Dec;7(1):6. doi: 10.1038/s41598-017-00059-1. |
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity
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Citation:
Cell Disc. 2017;3:17003. doi:10.1038/celldisc.2017.3 Epub:
Not Epub Abstract:
Wnt/β-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: He X, Zhang W, Yan C, Nie F, Li C, Liu X, Fei C, Li D, Song X, Jia Y, Zeng R, Wu D, Pan W, Hao X, Li L. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Disc. 2017;3:17003. doi:10.1038/celldisc.2017.3. |
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis
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Citation:
Am J Hum Genet. 2017 Jan 20. pii: S0002-9297(17)30005-8. doi: 10.1016/j.ajhg.2017.01.005. [Epub ahead of print] Epub:
Yes Abstract:
Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal genetic childhood motor neuron disease. SMN1... Organism or Cell Type:
zebrafish Citation Extract: Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B. Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. Am J Hum Genet. 2017 Jan 20. pii: S0002-9297(17)30005-8. doi: 10.1016/j.ajhg.2017.01.005. [Epub ahead of print]. |
The translational blocking of α5 and α6 integrin subunits affects migration and invasion, and increases sensitivity to carboplatin of SKOV-3 ovarian cancer cell line
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Citation:
Exp Cell Res. 2017 Jan 25. pii: S0014-4827(17)30019-8. doi: 10.1016/j.yexcr.2017.01.010. [Epub ahead of print] Epub:
Not Epub Abstract:
Epithelial ovarian cancer is the most lethal gynecologic malignancy. Integrins, overexpressed in cancer, are involved in... Organism or Cell Type:
cell culture: SKOV-3 ovarian cancer Citation Extract: Villegas-Pineda JC, Toledo-Leyva A, Osorio-Trujillo JC, Hernández-Ramírez VI, Talamás-Rohana P. The translational blocking of α5 and α6 integrin subunits affects migration and invasion, and increases sensitivity to carboplatin of SKOV-3 ovarian cancer cell line. Exp Cell Res. 2017 Jan 25. pii: S0014-4827(17)30019-8. doi: 10.1016/j.yexcr.2017.01.010. [Epub ahead of print]. |
Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development
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Citation:
Dev Biol. 2017 Jan 15;421(2):171-182. doi: 10.1016/j.ydbio.2016.11.021 Epub:
Not Epub Abstract:
Mutations in SIX1 and in its co-factor, EYA1, underlie Branchiootorenal Spectrum disorder (BOS), which is characterized by... Organism or Cell Type:
Xenopus Citation Extract: Neilson KM, Abbruzzesse G, Kenyon K, Bartolo V, Krohn P, Alfandari D, Moody SA. Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development. Dev Biol. 2017 Jan 15;421(2):171-182. doi: 10.1016/j.ydbio.2016.11.021. |
An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation
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Citation:
Development. 2017 Jan 15;144(2):321-333. doi: 10.1242/dev.147462 Epub:
Not Epub Abstract:
The signal-induced proliferation-associated family of proteins comprises four members, SIPA1 and SIPA1L1-3. Mutations of the... Delivery Method:
http://dev.biologists.org/content/144/2/321 Organism or Cell Type:
Xenopus Citation Extract: Rothe M, Kanwal N, Dietmann P, Seigfried FA, Hempel A, Schütz D, Reim D, Engels R, Linnemann A, Schmeisser MJ, Bockmann J, Kühl M, Boeckers TM, Kühl SJ. An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development. 2017 Jan 15;144(2):321-333. doi: 10.1242/dev.147462. |
In vivo translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis
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Citation:
bioRxiv. 2017. doi:10.1101/103481 Epub:
Not Epub Abstract:
Background: Genetic alterations impacting on ubiquitously expressed proteins involved in mRNA metabolism often result in... Delivery Method:
i.v. injection Organism or Cell Type:
mice, SMA Citation Extract: Bernabò P, Tebaldi T, Groen EJN, Lane FM, Perenthaler E, Mattedi F, Newbery HJ, Zhou H, Zuccotti P, Potrich V, Muntoni F, Quattrone A, Gillingwater TH, Viero1 G. In vivo translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis. bioRxiv. 2017. doi:10.1101/103481. |
Kif4 Is Essential for Mouse Oocyte Meiosis
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Citation:
PLoS One. 2017 Jan 26;12(1):e0170650. doi: 10.1371/journal.pone.0170650 Epub:
Not Epub Abstract:
Progression through the meiotic cell cycle must be strictly regulated in oocytes to generate viable embryos and offspring.... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Camlin NJ, McLaughlin EA, Holt JE. Kif4 Is Essential for Mouse Oocyte Meiosis. PLoS One. 2017 Jan 26;12(1):e0170650. doi: 10.1371/journal.pone.0170650. |
The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell's longest axis in the apical plane and relies on asynchronous cell divisions
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Citation:
Elife. 2017 Jan 25;6. pii: e19290. doi: 10.7554/eLife.19290. [Epub ahead of print] Epub:
Not Epub Abstract:
The ascidian embryo is an ideal system to investigate how cell position is determined during embryogenesis. Using 3D timelapse... Delivery Method:
microinjection Organism or Cell Type:
Phallusia mammillata (ascidian) Citation Extract: Dumollard R, Minc N, Salez G, Ben Aicha S, Bekkouche F, Hebras C, Besnardeau L, McDougall A. The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell's longest axis in the apical plane and relies on asynchronous cell divisions. Elife. 2017 Jan 25;6. pii: e19290. doi: 10.7554/eLife.19290. [Epub ahead of print]. |