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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning
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Citation:
PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018 Epub:
Not Epub Abstract:
Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018. |
A molecular mechanism for Wnt ligand-specific signaling
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Citation:
Science. 2018 Aug 17;361(6403). pii: eaat1178. doi:10.1126/science.aat1178. Epub 2018 Jul 19 Epub:
Not Epub Abstract:
Wnt signaling is key to many developmental, physiological, and disease processes in which cells seem able to discriminate... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B. A molecular mechanism for Wnt ligand-specific signaling. Science. 2018 Aug 17;361(6403). pii: eaat1178. doi:10.1126/science.aat1178. Epub 2018 Jul 19. |
Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential
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Citation:
bioRXive. 2018;[Epub] doi:10.1101/433391 Epub:
Not Epub Abstract:
Centromeres provide a robust model for epigenetic inheritance as they are specified by sequence-independent mechanisms... Organism or Cell Type:
Patiria miniata (starfish) Citation Extract: Swartz SZ, McKay LS, Su K-C, Padeganeh A, Paul S. Maddox PS, Knouse KA, Cheeseman I. Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential. bioRXive. 2018;[Epub] doi:10.1101/433391. |
DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring
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Citation:
Neural Dev. 2018 Sep 15;13(1):22. doi: 10.1186/s13064-018-0118-5 Epub:
Not Epub Abstract:
BACKGROUND: Proper patterning of dendritic and axonal arbors is a critical step in the formation of functional neuronal... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Santos RA, Fuertes AJC, Short G, Donohue KC, Shao H, Quintanilla J, Malakzadeh P, Cohen-Cory S. DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural Dev. 2018 Sep 15;13(1):22. doi: 10.1186/s13064-018-0118-5. |
Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo
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Citation:
Blood Adv. 2018;2:2589-606. doi:10.1182/bloodadvances.2018020156 Epub:
Not Epub Abstract:
The transcriptional repressors Gfi1(a) and Gfi1b are epigenetic regulators with unique and overlapping roles in hematopoiesis.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Moore C, Richens JL, Hough Y, Ucanok D, Malla S, Sang F, Chen Y, Elworthy S, Wilkinson RN, Gering M. Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood Adv. 2018;2:2589-606. doi:10.1182/bloodadvances.2018020156. |
Myogenin promotes myocyte fusion to balance fibre number and size
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Citation:
Nat Comm. 2018;9:4232. doi:10.1038/s41467-018-06583-6 Epub:
Not Epub Abstract:
Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ganassi M, Badodi S, Quiroga HPO, Zammit PS, Hinits Y, Hughes SM. Myogenin promotes myocyte fusion to balance fibre number and size. Nat Comm. 2018;9:4232. doi:10.1038/s41467-018-06583-6. |
The microRNA, miR-18a, regulates NeuroD and photoreceptor differentiation in the retina of the zebrafish
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Citation:
Dev Neurobiol. 2019 Jan 7. doi: 10.1002/dneu.22666. [Epub ahead of print] Epub:
Yes Abstract:
During embryonic retinal development, six types of retinal neurons are generated from multipotent progenitors in a strict... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Taylor SM, Giuffre E, Moseley P, Hitchcock PF. The microRNA, miR-18a, regulates NeuroD and photoreceptor differentiation in the retina of the zebrafish. Dev Neurobiol. 2019 Jan 7. doi: 10.1002/dneu.22666. [Epub ahead of print]. |
Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD
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Citation:
Hum Mol Genet. 2018;ddy353 doi:10.1093/hmg/ddy353 Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused by lack of the cytoskeletal protein... Delivery Method:
peptide-linked Organism or Cell Type:
mice mdx Citation Extract: Guiraud S, Edwards B, Squire SE, Moir L, Berg A, Babbs A, Ramadan N, Wood MJ, Davies KE. Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD. Hum Mol Genet. 2018;ddy353 doi:10.1093/hmg/ddy353 . |
Evaluation of the Effect of 2’-O-Methyl, Fluoro Hexitol, Bicyclo and Morpholino Nucleic Acid Modifications on Potency of GalNAc Conjugated Antisense Oligonucleotides in Mice
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Citation:
Bioorg Med Chem Lett. 2018;[Epub ahead of print] doi:10.1016/j.bmcl.2018.10.011 Epub:
Not Epub Abstract:
The potency of antisense oligonucleotide (ASO) drugs has significantly improved in the clinic after exploiting... Delivery Method:
GalNAc-linked Organism or Cell Type:
mice Citation Extract: Prakash TP, Yu J, Kinberger GA, Low A, Jackson M, Rigo F, Swayze EE, Seth PP. Evaluation of the Effect of 2’-O-Methyl, Fluoro Hexitol, Bicyclo and Morpholino Nucleic Acid Modifications on Potency of GalNAc Conjugated Antisense Oligonucleotides in Mice. Bioorg Med Chem Lett. 2018;[Epub ahead of print] doi:10.1016/j.bmcl.2018.10.011. |
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
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Citation:
Sci Translat Med. 2018;10(462):eaam7486 doi:10.1126/scitranslmed.aam7486 Epub:
Not Epub Abstract:
Developing and mature chondrocytes constantly interact with and remodel the surrounding extracellular matrix (ECM). Recent... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Song EK, Jeon J, Jang DG, Kim HE, Sim HJ, Kwon KY, Medina-Ruiz S, Jang H-J, Lee AR, Rho JG, Lee H-S, Kim SJ, Park CY, Myung K, Kim W, Kwon T, Yang S, Park TJ. ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis. Sci Translat Med. 2018;10(462):eaam7486 doi:10.1126/scitranslmed.aam7486 . |