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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
CCAAT/enhancer-binding protein-β functions as a negative regulator of Wnt/β-catenin signaling through activation of AXIN1 gene expression
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Citation:
Cell Death & Disease. 2018;9:1023. doi:10.1038/s41419-018-1072-1 Epub:
Not Epub Abstract:
Axin1, a concentration-limiting component of the β-catenin destruction complex, negatively regulates the Wnt/β-catenin pathway... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Park S, Lee M-S, Gwak J, Choi T-I, Lee Y, Ju BG, Kim C-H, Oh S. CCAAT/enhancer-binding protein-β functions as a negative regulator of Wnt/β-catenin signaling through activation of AXIN1 gene expression. Cell Death & Disease. 2018;9:1023. doi:10.1038/s41419-018-1072-1. |
Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment
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Citation:
Hum Mol Genet. 2018 Oct 2. doi: 10.1093/hmg/ddy346. [Epub ahead of print] Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature... Delivery Method:
peptide-linked Organism or Cell Type:
mice mdx Citation Extract: Betts CA, McClorey G, Healicon R, Hammond SM, Manzano R, Muses S, Ball V, Godfrey C, Merritt TM, Westering T, O'Donovan L, Wells KE, Gait MJ, Wells DJ, Tyler D, Wood MJ. Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment. Hum Mol Genet. 2018 Oct 2. doi: 10.1093/hmg/ddy346. [Epub ahead of print]. |
Poor Splice-Site Recognition in a Humanized Zebrafish Knockin Model for the Recurrent Deep-Intronic c.7595-2144A>G Mutation in USH2A
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Citation:
Zebrafish. 2018 Oct 3. doi: 10.1089/zeb.2018.1613. [Epub ahead of print] Epub:
Yes Abstract:
The frequent deep-intronic c.7595-2144A>G mutation in intron 40 of USH2A generates a high-quality splice donor site,... Organism or Cell Type:
zebrafish Citation Extract: Slijkerman R, Goloborodko A, Broekman S, de Vrieze E, Hetterschijt L, Peters T, Gerits M, Kremer H, van Wijk E. Poor Splice-Site Recognition in a Humanized Zebrafish Knockin Model for the Recurrent Deep-Intronic c.7595-2144A>G Mutation in USH2A. Zebrafish. 2018 Oct 3. doi: 10.1089/zeb.2018.1613. [Epub ahead of print]. |
Regulatory cocktail for dopaminergic neurons in a protovertebrate identified by whole-embryo single-cell transcriptomics
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Citation:
Genes Dev. 2018 Sep 18. doi: 10.1101/gad.317669.118. [Epub ahead of print] Epub:
Yes Abstract:
The CNS of the protovertebrate Ciona intestinalis contains a single cluster of dopaminergic (DA) neurons, the coronet cells,... Delivery Method:
microinjection Organism or Cell Type:
Ciona intestinalis (ascidian) Citation Extract: Horie T, Horie R, Chen K, Cao C, Nakagawa M, Kusakabe TG, Satoh N, Sasakura Y, Levine M. Regulatory cocktail for dopaminergic neurons in a protovertebrate identified by whole-embryo single-cell transcriptomics. Genes Dev. 2018 Sep 18. doi: 10.1101/gad.317669.118. [Epub ahead of print]. |
RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus
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Citation:
Development. 2018;145:dev147769 doi: 10.1242/dev.147769 Epub:
Not Epub Abstract:
The developing vertebrate embryo is exquisitely sensitive to retinoic acid (RA) concentration, particularly during... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Janesick A, Tang W, Shioda T, Blumberg B. RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus. Development. 2018;145:dev147769 doi: 10.1242/dev.147769. |
Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
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Citation:
Nat Comm. 2018;9:4029. doi:10.1038/s41467-018-06510-9 Epub:
Not Epub Abstract:
Female meiotic divisions are extremely asymmetric, producing large oocytes and small polar bodies (PBs). In mouse oocytes, the... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Wei Z, Greaney J, Zhou C, Homer HA. Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes. Nat Comm. 2018;9:4029. doi:10.1038/s41467-018-06510-9. |
The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice
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Citation:
Sci Rep. 2018;8:14678. doi:10.1038/s41598-018-33045-2 Epub:
Not Epub Abstract:
The transcription factor FOXJ1 is essential for the formation of motile cilia throughout the animal kingdom. Target genes... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Beckers A, Ott T, Schuster-Gossler K, Boldt K, Alten L, Ueffing M, Blum M, Gossler A. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Sci Rep. 2018;8:14678. doi:10.1038/s41598-018-33045-2. |
Robust and stable transcriptional repression in Giardia using CRISPRi
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Citation:
BioRXive. 2018;358598. doi:10.1101/358598 Epub:
Not Epub Abstract:
Giardia lamblia is a binucleate protistan parasite causing significant diarrheal disease worldwide. An inability to target Cas9... Delivery Method:
electroporation Organism or Cell Type:
Giardia lamblia Citation Extract: McInally SG, Hagen KD, Nosala C, Williams J, Nguyen K, Booker J, Jones K, Dawson SC. Robust and stable transcriptional repression in Giardia using CRISPRi. BioRXive. 2018;358598. doi:10.1101/358598. |
A flow platform for degradation-free CuAAC bioconjugation
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Citation:
Nat Comm. 2018;9:4021. doi:10.1038/s41467-018-06551-0 Epub:
Not Epub Abstract:
The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However... Citation Extract: Hatit MZC, Reichenbach LF, Tobin JM, Vilela F, Burley GA, Watson AJB. A flow platform for degradation-free CuAAC bioconjugation. Nat Comm. 2018;9:4021. doi:10.1038/s41467-018-06551-0. |
Meis transcription factor maintains the neurogenic ectoderm and regulates the anterior-posterior patterning in embryos of a sea urchin, Hemicentrotus pulcherrimus
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Citation:
Dev Biol. 2018 Sep 25. pii: S0012-1606(18)30428-7. doi: 10.1016/j.ydbio.2018.09.018. [Epub ahead of print] Epub:
Yes Abstract:
Precise body axis formation is an essential step in the development of multicellular organisms, for most of which the molecular... Delivery Method:
microinjection Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin) Citation Extract: Yaguchi J, Yamazaki A, Yaguchi S. Meis transcription factor maintains the neurogenic ectoderm and regulates the anterior-posterior patterning in embryos of a sea urchin, Hemicentrotus pulcherrimus. Dev Biol. 2018 Sep 25. pii: S0012-1606(18)30428-7. doi: 10.1016/j.ydbio.2018.09.018. [Epub ahead of print]. |