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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43

Authors:
Bhattacharya S, Gargiulo D, Iovine MK
Citation:
Development. 2018;[Epub ahead of print] doi: 10.1242/dev.166975
Epub:
Yes
Abstract:
The correct positioning of joints in the vertebrate skeleton is not well understood. Mutations in connexin43 (cx43) cause the...
Link:
http://dev.biologists.org/content/early/2018/10/29/dev.166975
Organism or Cell Type:
zebrafish
Citation Extract:
Bhattacharya S, Gargiulo D, Iovine MK. Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43. Development. 2018;[Epub ahead of print] doi: 10.1242/dev.166975.

WDR5 regulates left-right patterning via chromatin dependent and independent functions

Authors:
Kulkarni SS, Khokha MF
Citation:
Development. 2018;[Epub ahead of print] doi: 10.1242/dev.159889
Epub:
Yes
Abstract:
Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain...
Link:
http://dev.biologists.org/content/early/2018/10/29/dev.159889
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kulkarni SS, Khokha MF. WDR5 regulates left-right patterning via chromatin dependent and independent functions. Development. 2018;[Epub ahead of print] doi: 10.1242/dev.159889.

Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency

Authors:
Tsai CR, Lee HF, Chi CS, Yang MT, Hsu CC
Citation:
Hum Mutat. 2018 Sep 27. doi: 10.1002/humu.23659. [Epub ahead of print]
Epub:
Yes
Abstract:
Aromatic l-amino acid decarboxylase deficiency (AADCD), attributed to mutations in the dopa decarboxylase (DDC) gene, is a rare...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23659
Organism or Cell Type:
cell culture: primary human lymphoblastoid cells
Citation Extract:
Tsai CR, Lee HF, Chi CS, Yang MT, Hsu CC. Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency. Hum Mutat. 2018 Sep 27. doi: 10.1002/humu.23659. [Epub ahead of print].

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

Authors:
Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH
Citation:
J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.
Epub:
Not Epub
Abstract:
Erythropoietin (EPO) signaling is critical to many processes essential to terminal erythropoiesis. Despite the centrality of...
Link:
http://www.jbc.org/content/293/51/19797.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26..

Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis

Authors:
Nguyen AL, Drutovic D, Vazquez BN, El Yakoubi W, Gentilello AS, Malumbres M, Solc P, Schindler K
Citation:
Curr Biol. 2018;28 [Epub ahead of print] doi:10.1016/j.cub.2018.08.052
Epub:
Yes
Abstract:
Errors in chromosome segregation during female meiosis I occur frequently, and aneuploid embryos account for 1/3 of all...
Link:
https://www.cell.com/current-biology/pdf/S0960-9822(18)31136-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Nguyen AL, Drutovic D, Vazquez BN, El Yakoubi W, Gentilello AS, Malumbres M, Solc P, Schindler K. Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis. Curr Biol. 2018;28 [Epub ahead of print] doi:10.1016/j.cub.2018.08.052.

Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development

Authors:
Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC
Citation:
Development. 2018;[Epub ahead of print] doi:10.1242/dev.167510
Epub:
Yes
Abstract:
A key event in heart development is the timely addition of cardiac progenitor cells, defects in which can lead to congenital...
Link:
http://dev.biologists.org/content/early/2018/10/20/dev.167510
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC. Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development. 2018;[Epub ahead of print] doi:10.1242/dev.167510 .

tbx5 and tbx15 mediate zebrafish posterior lateral line migration and development via a negative feedback loop

Authors:
Whitehurst HR, Gallardo VE, Burgess SM
Citation:
bioRxive. 2018;[preprint]:452797 doi:10.1101/452797
Epub:
Not Epub
Abstract:
The zebrafish posterior lateral line (pLL) is a mechanosensory organ enabling detection of movement in the aqueous environment...
Link:
https://www.biorxiv.org/content/early/2018/10/24/452797
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Whitehurst HR, Gallardo VE, Burgess SM. tbx5 and tbx15 mediate zebrafish posterior lateral line migration and development via a negative feedback loop. bioRxive. 2018;[preprint]:452797 doi:10.1101/452797 .

Increased dynamin expression precedes proteinuria in glomerular disease

Authors:
Khalil R, Koop K, Kreutz R, Spaink HP, Hogendoorn PCW, Bruijn JA, Baelde HJ
Citation:
J Pathol. 2018 Oct 22. doi: 10.1002/path.5181. [Epub ahead of print]
Epub:
Yes
Abstract:
Dynamin plays an essential role in maintaining the structure and function of the glomerular filtration barrier. Specifically,...
Link:
https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.5181
Citation Extract:
Khalil R, Koop K, Kreutz R, Spaink HP, Hogendoorn PCW, Bruijn JA, Baelde HJ. Increased dynamin expression precedes proteinuria in glomerular disease. J Pathol. 2018 Oct 22. doi: 10.1002/path.5181. [Epub ahead of print].

A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers

Authors:
Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS
Citation:
EMBO J. 2018 Oct 22. pii: e100241. doi: 10.15252/embj.2018100241. [Epub ahead of print]
Epub:
Yes
Abstract:
The mechanisms of mitochondrial dysfunction in Alzheimer's disease are incompletely understood. Using two‐photon...
Link:
http://emboj.embopress.org/content/early/2018/10/22/embj.2018100241
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse cortical neurons
Citation Extract:
Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. EMBO J. 2018 Oct 22. pii: e100241. doi: 10.15252/embj.2018100241. [Epub ahead of print].

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development

Authors:
Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS-K, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP
Citation:
PNAS USA. 2018;[Epub ahead of print] doi:10.1073/pnas.1811624115
Epub:
Yes
Abstract:
Codevelopment of the lungs and heart underlies key evolutionary innovations in the transition to terrestrial life. Cardiac...
Link:
http://www.pnas.org/content/early/2018/10/22/1811624115
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS-K, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP. Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. PNAS USA. 2018;[Epub ahead of print] doi:10.1073/pnas.1811624115.

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